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  • Articles  (3)
  • Glare  (2)
  • Key words IDDM, nerve conduction velocity, neuropathy, intensified insulin treatment.  (1)
  • 1990-1994  (3)
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  • Articles  (3)
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  • 1
    ISSN: 1432-0428
    Keywords: Key words IDDM, nerve conduction velocity, neuropathy, intensified insulin treatment.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have investigated the effect of long-term strict glycaemic control on peripheral and autonomic nerve function in 45 IDDM patients (age 18–42 years, diabetes duration 7–23 years) without clinical signs of neuropathy or other neurological disease. They were randomly assigned to treatment either with continuous insulin infusion, multiple injections (4–6 times daily), or conventional treatment (twice daily) for 4 years and followed prospectively for 8 years. Motor and sensory nerve conduction velocities were measured at the start and after 8 years. Autonomic nerve function tests were performed only once, after 8 years. A significant reduction of nerve conduction velocity was observed during 8 years in patients with mean HbA1 more than 10 % (n =12, group mean 10.9 %, range 10.1–13.2 %) compared to patients with HbA1 less than 10 % (n =33, group mean 9.0 %, range 7.5–9.9 %). Change of motor nerve conduction velocity in the peroneal nerve was: –4.8±4.9 (SD) vs –2.2±5.3 m/s (p〈0.01). Change of motor nerve conduction velocity in the posterior tibial nerve was: –6.8±5.7 vs –3.9±5.1 m/s (p〈0.05). No significant changes were observed in the ulnar nerve. Change of sensoric nerve conduction velocity in the sural nerve was: –8.9±8.0 vs –4.6±5.3 m/s (p〈0.05). Multiple regression analysis showed that a change in HbA1 of 1 % resulted in a 1.3 m/s change in nerve conduction velocity during 8 years. A significantly lowered heart-rate variation during deep breathing (p〈0.05) and heart-rate response to standing (p〈0.01) was found in patients with HbA1 more than 10 % compared to patients with HbA1 less than 10 %. This study confirms that the long-term lowering of blood glucose retards the deterioration in nerve conduction velocity observed in the diabetic nerve. [Diabetologia (1994) 37: 579–584]
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2622
    Keywords: Corneal dystrophy ; Glare ; Straylight
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The direct compensation method allows for an accurate determination of intraocular light scattering between 3.5 and 25 degrees of scattering angle and is suitable for untrained subjects. The method was used to study light scattering in four forms of hereditary corneal dystrophies. Light scattering is the basis of glare complaints and was compared with visual acuity loss. The findings corresponded to the complaint patterns: in central crystalline dystrophy light scattering can be much increased with relatively well preserved visual acuity. In posterior polymorphous dystrophy the reverse is true. In macular dystrophy (Groenouw II) and lattice dystrophy the situation is more or less intermediate between these two extremes.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Documenta ophthalmologica 78 (1991), S. 177-181 
    ISSN: 1573-2622
    Keywords: Glare ; straylight ; contrast sensitivity ; light scatter ; disability glare ; discomfort glare
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An overview is given of the basic phenomena that may lead to glare complaints in patients. Prominent among them is increased intraocular straylight; this can be measured. Other causes may include: increased sensitivity to normal straylight, the length of (increased) light and dark adaptation times, (small angle) neuronal lateral interaction. Distinction must be made between disability glare and discomfort glare. Tests have been proposed to determine glare-induced loss of various visual functions. Often the test results are thought to be directly related to straylight but this may be untrue.
    Type of Medium: Electronic Resource
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