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  • Carnitine  (1)
  • Immune competence  (1)
  • Key words Infertility • ICSI • TESE • Reproductive medicine  (1)
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  • 1
    ISSN: 1433-0563
    Keywords: Key words Infertility • ICSI • TESE • Reproductive medicine ; Schlüsselwörter Infertilität • ICSI • TESE • Reproduktionsmedizin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach den ersten Erfolgen der in-vitro Fertilisation 1978 wurden die verschiedenen Techniken der ovariellen Stimulation, der Eizellengewinnung und der Embryonenkultivierung entscheidend verbessert. Die Entwicklung von Mikroinjektionstechniken war ein Meilenstein in der Reproduktionsmedizin. Sogar in Fällen ausgeprägter Verminderung der Samenqualität konnten Schwangerschaftsraten von ungefähr 20 % pro Behandlung nach der Anwendung der intrazytoplasmatischer Spermieninjektion (ICSI) erreicht werden. Wesentliche Eckpunkte bei dem Einsatz von reproduktionsmedizinischen Maßnahmen (ART) ist die Altersgrenze der Frau sowie das vorzeitige Erlöschen der Ovarialfunktion und die Möglichkeit beim Mann Spermatozoen zu gewinnen. Deshalb ist ein interdisziplinäres Vorgehen Voraussetzung, um den komplexen Problemen eines betroffen Paares gerecht zu werden. Es gibt Hinweise, daß Kinder, die nach Mikroinjektionstechniken geboren wurden, ein höheres Risiko für chromosomale Veränderungen haben. Trotz allem scheinen die Prozentsätze von schweren Fehlbildungen nach reproduktionsmedizinischen Maßnahmen im Vergleich zur Normalbevölkerung gleich zu sein. Eine Abschätzung des möglichen Risikos und der Erfolgsaussichten sowie die gründliche Beratung des betroffenen Paares muß vor Einleitung invasiver reproduktionsmedizinischer Verfahren erfolgen.
    Notes: Summary Since the first child was born after in-vitro fertilization in 1978, different techniques of ovarian stimulation, oocyte retrieval and embryo culture have improved significantly. The development of microinjection techniques was a mile stone in reproductive medicine. Even in cases of severe impairment of semen quality, using the Intracytoplasmic Sperm Injection (ICSI), pregnancy rates of approximately 20 % per treatment cycle can be achieved. However for using artificial reproductive techniques (ART) the female age is a major limiting factor as well as the development of premature ovarian failure (POF). Crucial for the male is the question whether or not sperm cells can be retrieved. Today an interdisciplinary approach is recommended to take care of the afflicted couple in order to address the complex problem of infertility. There is evidence that children born after microinjection techniques bare a higher risk for chromosomal aberrations compared to the normal population. However rates of major malformations seem to be identical in both groups. An evaluation of the potential risks and efforts and an extensive counseling of the infertile couple has to be taken before initiating invasive ART.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 14 (1986), S. 241-246 
    ISSN: 1434-0879
    Keywords: Seminal fluid ; Biochemical analysis ; Citrate ; Fructose ; Carnitine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The measurement of biochemical markers in human seminal plasma is important in the evaluation of male infertility. We recommend the measurement of one representative substance for each organ involved in seminal fluid production as a routine diagnostic tool: The initial fructose level for seminal vesicular function, citrate or acid phosphatase for the prostate gland and free carnitine as an index of epididymal function. A biochemical analysis of seminal fluid enables us to detect disturbances of the male adnexal organs and may lead to more exact therapy.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1335
    Keywords: Whole blood cell cultures ; Cytokine production ; Urogenital carcinomas ; Immune competence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The production of the cytokines interferon γ (IFN γ), interleukin-1 α (IL-1 α) and tumor necrosis factor α (TNF α) was investigated in the mitogen-stimulated whole blood cell culture media from 51 patients with urinary bladder carcinomas, 52 patients with renal carcinomas, 31 patients with prostatic carcinomas and 360 healthy controls. The cytokines were measured 4 days after induction by a sensitive enzymo-immunological assay. In the blood cell culture supernatants of the patients with urinary bladder carcinomas significancy lower levels of IFN γ (P≤0.001), IL-2 (P≤0.001) and TNFα (P≤0.05) were found as compared to the controls. Blood cells of patients with renal carcinomas had lower production of IFN γ (P≤0.01), IL-2 (P≤0.001) and IL-1α (P≤0.01), whereas the values of the total group of patients with prostatic carcinomas were not significantly different from those of the controls. Lymphocyte and monocyte counts were almost identical in the control and all tumor patient groups. When the patients with renal carcinomas and prostatic carcinomas were analyzed according to their different clinical stages we could show a gradual depression of the IFN-γ levels, which was related to tumor burden.
    Type of Medium: Electronic Resource
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