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  • Key words. Calcium channels; molecular cloning; gene expression; antihypertensives; antiepileptics.  (1)
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    ISSN: 1420-9071
    Keywords: Key words. Calcium channels; molecular cloning; gene expression; antihypertensives; antiepileptics.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Despite the wealth of information on voltage-gated calcium channels, little is known about low voltage-activated, T-type channels. The ability of the antihypertensive drug mibefradil to selectively block T-type channels has generated much interest in their structure, physiology and pharmacology. This review covers the cloning of a new family of calcium channels, their putative structure, the electrophysiological evidence that demonstrated that these complementary DNAs encoded low voltage-activated, T-type channels, the tissue expression of these genes, and concludes with a discussion of their possible physiological roles.
    Type of Medium: Electronic Resource
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