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  • 1
    ISSN: 1432-1076
    Keywords: Mitochondrial myopathy ; Lactic acidosis ; Respiratory chain ; Succinate cytochrome-c-oxidoreductase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A male infant had severe muscular hypotonia from birth. Recurrent vomiting with dehydration and severe metabolic acidosis complicated the course. Elevated lactate (up to 12.3 mmol/l; n〈2), pyruvate (0.4 mmol/l; n〈0.05) and alanine levels were found in serum with an abnormal lactate/pyruvate ratio (〉30; n〈15). In urine the concentrations of lactate, pyruvate, alanine and of several intermediates of the citric acid cycle were increased. In muscle, numerous disseminated “ragged red fibres” were found by light microscopy; muscle fibres were found to contain subsarcolemmal aggregates of mitochondria, lipid droplets and glycogen by electromicroscopical methods. More-over, mitochondria with a typical circular arrangement of cristae were noticed. In liver homogenates normal activities of pyruvate carboxylase and pyruvate dehydrogenase complex were found; in liver mitochondria also succinate-cytochrome-c-oxidoreductase activity was normal. However, in muscle no succinate-cytochrome-c-oxidoreductase activity was detectable. The patient became increasingly lethargic and died because of sepsis at 5 months of age.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 6 (1980), S. 235-238 
    ISSN: 1432-1238
    Keywords: Lactic acidosis ; Hyperlactataemia ; Urinary lactic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A new simple rapid test for the detection of increased urinary lactic acid is described. The method depends on the transformation of lactic acid to acetaldehyde by cesium IV. Acetaldehyde reacts with sodium nitroprusside producing a blue color. Patients from an emergency ward and patients with experimentally induced hyperlactatemia have been screened with this test. The results confirm that there exists a correlation between blood and urinary lactate levels and that a clinically relevant hyperlactatemia is associated with an increased urinary lactate concentration which can be reliably detected with this test.
    Type of Medium: Electronic Resource
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