Life and Medical Sciences
Cell & Developmental Biology
Wiley InterScience Backfile Collection 1832-2000
In order to evaluate pathological alterations of the inclusion bodies of Type II cells in the mammalian lung, normal morphology of inclusions has been studied in rabbit, sheep, rat, mouse, dog, hamster and guinea pig. In rabbit, and sheep the fetal development of the inclusions has also been investigated.After a standard method of fixation, three different types of inclusions have been found in the species studied. The first type of inclusion is seen in the fetal rabbit, fetal sheep, dog, rat and mouse. In these species the inclusions contain heavily osmiophilic, coarsely lamellar material. In all of these species, the inclusions seem to form from an interaction between tubulo-vesicular bodies, located near the Golgi apparatus, and multivesicular bodies. These are certain variations in the appearance of the inclusions among these species.The second type of inclusion is seen in the hamster and guinea pig, in which lightly osmiophilic material accumulates during the maturation of the inclusions. In these species, a granular dense body seems to occupy an important role in the formation of the inclusion bodies.In the third group, the postnatal rabbit and sheep, the inclusions appear vacuolated.It is postulated that the seemingly inconsistent results of the acid phosphatase activity of inclusions in several species may indeed be a reflection of species differences in the mode of formation of inclusion bodies.
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