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  • Splanchnic  (2)
  • Alzheimer  (1)
  • Lindankinetik im Serum  (1)
  • subthalamic nucleus
  • Deep brain stimulation
  • Inorganic Chemistry
  • Springer  (4)
  • 1
    ISSN: 1573-6903
    Keywords: Prothrombin ; ELISA ; cerebrospinal fluid ; blood-CSF barrier ; Alzheimer ; neurological disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prothrombin, known to be expressed in brain and to possess growth modulating properties, has been suggested to be involved in the pathogenesis of Alzheimer's disease (AD). We studied prothrombin concentration in lumbar CSF (L-CSF) in patients with AD (n = 25), neurologic disease controls (NDC; n = 33) covering a wide range of neurologic disorders, and subjects with Guillain-Barré syndrome (GBS; n = 4) as well as in samples of non-pathological ventricular CSF (V-CSF; n = 4). The results were evaluated with respect to CSF flow rate, as indicated by the albumin quotient (QAlb). The concentrations of prothrombin in L-CSF in NDC (mean: 0.46 mg/l, range: 0.21–0.96), and AD (mean: 0.6 mg/l, range: 0.19–1.2) were in the normal range reported previously. Expectedly, prothrombin concentration in L-CSF of GBS was increased (mean: 6.3 mg/l, range: 2.3–9.7) corresponding to the increased QAlb in this group (mean 54.6 × 10−3, range: 17–88.1). The concentrations of both prothrombin and albumin were 5.5-fold higher in L-CSF than in V-CSF (mean QAlb : 1.1 × 10−3, mean concentration of prothrombin: 0.088 mg/l). In conclusion, CSF prothrombin in all conditions evaluated here is exclusively derived from blood.
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  • 2
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    Intensive care medicine 21 (1995), S. 352-355 
    ISSN: 1432-1238
    Keywords: Liver ; Metastasis ; Splanchnic ; Oxygen consumption ; Sepsis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Metastatic liver disease can modify the metabolic response to critical illness. Systemic lactic acidosis may arise from an increased production due to inadequate peripheral tissue oxygen transport, altered metabolic function such as depressed pyruvate oxidation or insufficient hepatic clearing capacity due to tumor replacement of functional liver mass. Hepatic venous catheterization in a patient with extensive metastatic melanoma to the liver and adult respiratory distress syndrome indicated a marked disparity between whole body and liver oxygenation which may arise due to a markedly stepped up splanchnic oxygen utilization unmatched by a proportionate rise in regional oxygen delivery. Since some neoplasms may exhibit increased metabolic activity, it is suspected that these metastatic lesions may have contributed to the observed regional hypermetabolism thereby worsening hepatic hypoxia and exacerbating lactic acidosis. This case also illustrates the difficulties in interpreting global indicators of metabolic function and oxygenation in critically ill patients.
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  • 3
    ISSN: 1432-1238
    Keywords: Venous oxygen saturation ; Oxygen transport ; Splanchnic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Central mixed venous oxygen saturation (S $$\mathop v\limits^ - $$ O2) monitoring in critically ill patients to estimate adequacy of peripheral perfusion is gaining increasing popularity. However, a number of unexpected responses, one of which is marked depression of regional (splanchnic) venous oxygen saturation which may coexist with normal or high S $$\mathop v\limits^ - $$ O2, makes interpretation pretation of this parameter difficult. The S $$\mathop v\limits^ - $$ O2 and hepatic venous oxygen saturation levels in seven injured (postoperative) and 15 septic patients were measured. No substantial differences between central and hepatic venous oxygen saturation were noted in nonseptic patients, however, septic subjects exhibited a normal S $$\mathop v\limits^ - $$ O2 of 70.5%±8.7% at a time when the hepatic venous saturation was 55.6%±14.4% which is a significant (p〈0.05) reduction. This reduced oxygen saturation was noted to arise from an increased regional metabolic rate rather than reduced perfusion. Nevertheless, we conclude that a flow limited regional oxygen consumption may potentially exist despite the presence of a normal S $$\mathop v\limits^ - $$ O2 in certain patient subgroups such as septic subjects. Therefore, a normal S $$\mathop v\limits^ - $$ O2 should not be considered as sole criteria to insure optimal oxygen delivery in critically ill patients.
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  • 4
    ISSN: 1432-069X
    Keywords: Elimination of “poison” ; Lindan absorption ; Scabies-therapy ; Serumconcentration of Lindan ; Serumkinetic of Lindan ; “Gift” elimination ; Lindanresorption ; Scabiestherapie ; Serumkonzentration von Lindan ; Lindankinetik im Serum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach lokaler Ganzkörper-Applikation einer 0,3%igen Lindan-Emulsion bei hautgesunden Probanden und bei scabieserkrankten Patienten wurde die Konzentration von Lindan im Serum während 143 bzw. 55 h untersucht. Die Bestimmung erfolgte gaschromatographisch. Verschiedene den üblichen Therapiearten angepaßte Variationen der Behandlungsweise wurden vergleichend durchgeführt. Kriterien wie Applikationshäufigkeit, Abwaschen des applizierten Präparates mit Wasser (Duschen) unter Verwendung von Seife bzw. keiner Seife oder Vollbad ohne Seife bei Hautkranken jeweils zu verschiedenen Zeiten nach der lokalen Applikation wurden herausgearbeitet. Aus den vorliegenden Daten kann folgendes festgehalten werden: 1. Normalpersonen (im Alter von 23) einer deutschen Gro\sBstadt haben im jetzigen Zeitraum eine Lindan-Konzentration von etwa 3 ng/ml (0,003 ppm) im Blutserum. 2. Scabieskranke, die in einer Gro\sBstadt zur station\:aren Einweisung kommen, haben am Aufnahmetag einen zehnfach h\:oheren Ausgangswert (um 0,04 ppm), wahrscheinlich bedingt durch ineffektive sporadische Vorbehandlungen. Trotz dreimaliger lokaler Ganzkörperbehandlung im Abstand von 24 h sinkt das etwa 4–6 h danach auftretende Konzentrationmaximum innerhalb 3–5 h stets auf ähnliche Werte (um 10 ng/ml) ab. 3. Abduschen mit Wasser und Seife verringert bei Hautgesunden die Resorption nur, wenn dies erst l\:angere Zeit (8\2-12 h) nach der Applikation erfolgt. Kurzfristiges Abwaschen zur Verhinderung einer \ldGiftresorption\rd bewirkt das Gegenteil vom Gew\:unschten. Vollb\:ader bei Hautkranken 10 h nach der Lokalapplikation scheint die Resorption zu verst\:arken. 4. Bei nicht intaktem Integument (generalisierte excoriierte impetiginisierte Scabies) werden bei M\:annern Serumkonzentrationen von maximal 0,425 ppm gefunden. Der Extremwert bei hautgesunden M\:annern lag bei 0,0095 ppm.
    Notes: Summary A 0.3% lindane emulsion was applied to the entire body of volunteers with a healthy skin and that of scabious patients. The resulting lindane levels in the serum were followed up over periods of 143 and 55h, respectively. The lindane levels in the serum were determined with the aid of gas chromatography. A comparative evaluation of a number of modifications of therapy in accordance with the common ways of treatment was conducted using criteria, such as frequency of application, removal of the applied preparation by washing with water (shower) with and without soap, or by means of a complete bath without soap (in the case of dermatologic patients) at various times after topical application. On the basis of the data obtained, the following findings were established: 1. At present, normal persons aged 23 and living in a large German city were found to exhibit lindane levels of approximately 3 ng/ml (0.003 ppm) in their blood serum. 2. Scabious patients hospitalized in a large city had initial values on the day of their hospitalization exceeding those of normal persons by a factor of 10 (around 0.04 ppm). This has been assumed to be due to ineffective and sporadic pretreatment. Despite application of lindane to the entire body (three times at 24 h intervals), the maximal levels occurring approximately 4–6 h after application always dropped to similar values (around 10 ng/ml) within 3–5 h. 3. In volunteers with healthy skin, absorption was reduced by taking showers (and using water and soap) only if an extended period (8\2-12 h) had passed since application. Washing to prevent \ldabsorption of the poison\rd shortly after application improved absorption rather than prevented it. In dermatologic patients, complete baths taken 10 h after topical application seemed to enhance absorption. 4. Serum levels of up to 0.425 ppm were found in male patients whose integument was not intact (generalized excoriated and impetiginized scabies). In males with a healthy skin, extreme values were found to be around 0.0095 ppm.
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