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  • 1
    ISSN: 1432-0533
    Keywords: Wallerian Degeneration ; Peripheral Nerves ; Macrophages ; Monocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The origin of the macrophages in peripheral nerves was investigated in newborn rabbits after labelling the blood monocytes with intravenous carbon suspensions. Carbon labelled lipid macrophages were observed at the site of trauma in the nerves but not in areas of Wallerian degeneration. It is suggested that in Wallerian degeneration, resorption of degenerate tissue is performed by endogenous cells only, while in traumatic lesions part of the phagocytosis is performed by migrated monocytes. The early increase in vascular permeability in traumatic lesions may be a prerequisite for the attraction of the monocytes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 173 (1976), S. 343-348 
    ISSN: 1432-0878
    Keywords: Retrograde degeneration ; Wallerian degeneration ; Macrophages ; Hematogenous origin ; 3H-DFP-Labeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In order to examine the possible haematogenous origin of phagocytes in anterograde and retrograde degeneration, rabbit peritoneal macrophages were labeled in vitro with 3H-DFP and injected intravenously into host animals. Four or five days prior to the injection, the facial nerve was avulsed and the sciatic nerve ligated in five recipients. The animals were killed 24 h after the injection of the macrophages. Labeled cells were found in that part of the sciatic nerve which was mechanically damaged and in the liver and spleen but not in areas with retrograde or Wallerian degeneration. The possible interpretation of these findings is discussed.
    Type of Medium: Electronic Resource
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