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  • Melatonin receptors  (1)
  • iontophoresis  (1)
  • 1
    ISSN: 1435-1463
    Keywords: SCN neurons ; circadian rhythm ; iontophoresis ; melatonin receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Circadian rhythms, endogenously generated in suprachiasmatic nuclei (SCN), seem to be under the direct influence of melatonin. Therefore, the effect of iontophoretically applied melatonin on electrical activity of SCN neurons was investigated in vitro. Usually, melatonin had an inhibitory effect. In the 3-h periods before (2.00–5.00 p.m.) or after (5.00–8.00 p.m.) the light-dark transition the percentage of SCN neurons sensitive to melatonin was very high (80% and 100%, respectively). However, efficacy of melatonin was low in the periods preceeding (20%) and following (33%) this 6-h time interval.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1463
    Keywords: Melatonin receptors ; chicken brain ; visual suprachiasmatic nucleus ; 125I-melatonin ; receptorautoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Melatonin, released in a circadian manner from the avian pineal gland into the circulation, is concentrated in distinct brain areas, possibly by receptor-mediated uptake mechanisms. For anatomical localisation of putative melatonin receptors in birds, cryostat-cut, coronal 15 Μm brain sections of 2-day-old chicken were investigated by means of in vitro receptorautoradiography, using125I-melatonin as a ligand. Binding occurred in brain structures receiving or mediating visual or auditory sensory input. Binding characteristics were investigated in homogenates of a brain region labelled by125I-melatonin and showed to be specific and saturable (Kd: 87.2 pM; Bmax: 16.1 fmol/mg protein). Results confirm that a wealth of structures in chicken brain are equipped with putative melatonin receptors, including the visual suprachiasmatic nucleus. However, as results show that fewer structures were labelled in the brain of 2-day-old chicken as compared to a similar investigation conducted with 12-day-old chicken, developmental changes in distribution and/or density of putative melatonin receptors might be present.
    Type of Medium: Electronic Resource
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