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  • 42.55  (1)
  • 42.60  (1)
  • 42.65  (1)
  • Mibefradil  (1)
  • Springer  (3)
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  • Springer  (3)
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  • 1
    ISSN: 1432-1041
    Keywords: Key words: Calcium ; Mibefradil ; Mononuclear cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: A double-blind, placebo-controlled parallel study was conducted on the effect of mibefradil, both an L- and T-type Ca2+-channel blocker with a more selective blockade of T-type channels, administered once daily for 1 week to normal male subjects, on blood pressure, intracellular cationic concentrations, sodium-proton exchange rate and 3 H-thymidine incorporation in peripheral blood mononuclear cells (PBMC). Methods: After a 1-week run-in period on placebo, the subjects (n = 40) were allocated to a placebo or a mibefradil group. Placebo or 50 mg mibefradil was administered once daily in the morning for 1 week. All subjects were investigated at baseline and after 1 week of placebo or mibefradil administration. Standing or recumbent blood pressure and heart rate of subjects in the mibefradil group was decreased (P 〈 0.05 or less) compared with that of subjects in the placebo group. Results: Decreased (P 〈 0.001) intracellular free Ca2+ concentration and reduced (P 〈 0.001) 3 H-thymidine incorporation in the PBMC were observed in the mibefradil-treated subjects. The intracellular sodium, potassium or magnesium concentration as well as the sodium-proton exchange rate were not changed during mibefradil administration. Conclusion: The blood pressure lowering action of mibefradil in men is accompanied by a decrease in intracellular free Ca2+ concentration. Mibefradil also reduced the 3 H-thymidine incorporation or de novo DNA synthesis in PBMC by modulating the calcium homeostasis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0649
    Keywords: 42.55M ; 42.60
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The influence of depletable amplification, group velocity dispersion and self-phase modulation due to Kerr-type nonlinearity on pulse shaping in femtosecond pulse amplification has been calculated. With gain depletion which is typical for the last stage of multi-stage amplifiers, spectral broadening occurs which, under certain conditions, can be utilized for pulse compression. This spectral broadening as well as a predicted spectral shift is compared with experimental results.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0649
    Keywords: 42.65 ; 42.55
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The theory of active-passive mode-locked solid-state lasers is developed where the passive mode-locking is achieved by a nonlinear mirror. Steady-state cw numerical solutions are analyzed in detail for the case of a Nd: YAG laser. The steady-state pulse duration can be reduced by an order of magnitude as compared to the pure active mode-locking regime.
    Type of Medium: Electronic Resource
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