Region-selective inverse detected long-range heteronuclear chemical shift correlation
Analytical Chemistry and Spectroscopy
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
F1 region-selected variants of the HMBC experiment were compared and evaluated. In particular, a significant advantage was demonstrated for an E-BURP-2 pulse over a Gaussian 270° pulse for region-selected applications. The Gaussian 270° pulse would still, however, be the preferred pulse for use in single-resonance, on-resonance selective excitation. Data are presented from NMR spectrometers both equipped and not equipped with programmable pulse modulators (waveform generators). Pulse evaluations were performed using the simple heteroaromatic alkaloid quindoline; application of the technique to the important immunosuppressive cyclic peptide cyclosporin-A is also presented and discussed.
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