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  • 1
    Keywords: brain ; FOLLOW-UP ; magnetic resonance imaging ; ABNORMALITIES ; SCALE ; SENSORIMOTOR CORTEX ; MR-IMAGES ; VOXEL-BASED MORPHOMETRY ; DYSFUNCTION ; 1ST-EPISODE SCHIZOPHRENIA ; CEREBELLAR VOLUME ; Heidelberg scale ; Schizophrenia Neurological soft signs ; SOFT SIGNS
    Abstract: Neurological soft signs (NSS) comprise a broad range of minor motor and sensory deficits which are frequently found in schizophrenia. However, the cerebral changes underlying NSS are only partly understood. We therefore investigated the cerebral correlates of NSS by using magnetic resonance imaging (MRI) in 102 patients with first episode schizophrenia. NSS were assessed after remission of acute psychotic symptoms using the Heidelberg scale (HS), which consists of five NSS subscales ("motor coordination", "complex motor tasks", "orientation", "integrative functions", and "hard signs"). Correlations between NSS scores and cerebral changes were established by optimized voxel-based morphometry. NSS total scores were significantly associated with reduced gray matter densities in the precentral and postcentral gyri, the inferior parietal lobule and the inferior occipital gyrus. Both of the NSS subscales "motor coordination" and "complex motor tasks", referred to motor strip changes but showed differential correlations with parietal, insular, cerebellar or frontal sites, respectively. The NSS subscales "orientation" and "integrative functions" were associated with left frontal, parietal, and occipital changes or bihemispheric frontal changes, respectively. The NSS subscale "hard signs" was associated with deficits in the right cerebellum and right parastriate cortex. Repeated analyses for white matter changes revealed similar results. These findings confirm the associations between NSS and cerebral changes in areas important for motor and sensory functioning. This variety of cerebral sites corresponds to the heterogeneity of NSS and are consistent with the hypothesis that NSS reflect both a rather generalized cerebral dysfunction and localized deficits specific for particular signs.
    Type of Publication: Journal article published
    PubMed ID: 21498055
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  • 2
    ISSN: 1432-1440
    Keywords: Neuromuscular disorders ; Centronuclear myopathy ; Type I-fiber atrophy ; “Myotubelike structures” ; Neuromuskuläre Erkrankungen ; centronucleäre Myopathie ; Typ I-Faser Atrophie ; “Myotube-like structures”
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über eine Familie berichtet, in welcher sowohl die Mutter, als auch ihre beiden Töchter an einer congenitalen, langsam progredienten neuromuskulären Erkrankung leiden. Die im Rahmen der Muskelbiopsie zu erhebenden histologischen, histochemischen und ultrastrukturellen Befunde zeigen bei der Mutter das Vollbild der sog. centronucleären Myopathie. Die charakteristischen zentralständigen Kerne mit den umgebenden pericentronucleären Strukturanomalien der Fasern werden nahezu in allen Muskelfasern angetroffen. Bei den Töchtern dagegen sind morphologisch fast ausschließlich die Typ I-Fasern befallen, welche zusätzlich im Durchmesser kleiner als normal erscheinen. Der Nachweis dieser beiden Formen von centronucleärer Myopathie in einer Familie beweist, daß hier offenbar zwei morphologische Varianten, wahrscheinlich sogar Stadien eines Krankheitsbildes vorliegen. Das zusätzliche Vorhandensein einiger weiterer struktureller Besonderheiten (rod bodies, core-ähnliche Areale) unterstreicht die Verwandtschaft der Erkrankung mit anderen congenitalen langsam progredienten Myopathien (nemaline myopathy, central core disease).
    Notes: Summary This report deals with a family in which the mother and her two daughters suffer from a congenital, slowly progressive neuromuscular disease. Histological, histochemical and ultrastructural observations of the mother's muscle biopsy reveal the characteristics of the centronuclear myopathy. In this case central nuclei and pericentronuclear abnormalities of muscle fibers are found in almost all fibers. Biopsies obtained of the two daughters show alterations especially of type I-fibers, which often are smaller than normal. The presence of these two forms of centronuclear myopathy in one family indicates that these may be only different morphological types or states of one illness. Additionally, other structural findings (rod bodies, core like regions) emphasize the similarities with other congenital slowly progressive myopathies (nemaline myopathy, central core disease).
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1440
    Keywords: Neuromuscular disorders ; Congenital myopathy ; Central core disease ; “structured cores” in type II-fibers ; Neuromuskuläre Erkrankungen ; Congenitale Myopathie ; Central core disease ; „structured cores“ in Type II-Fasern
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über einen sporadischen Fall einer congenitalen langsam progredienten neuromuskulären Erkrankung berichtet. Die im Rahmen der Muskelbiopsie zu erhebenden lichtmikroskopischen, ultrastrukturellen und enzymhistochemischen Befunde entsprechen einer Central Core Disease mit „structured cores” in Typ II-Fasern.
    Notes: Summary Report on a sporadic case with congenital slowly progressive neuromuscular disease. Light microscopic, ultrastructural and histochemical changes of muscle biopsy reveal the characteristics of central core disease with “structured cores” in type II-fibers.
    Type of Medium: Electronic Resource
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