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  • GLIOMA  (3)
  • Nicotiana sylvestris  (3)
  • 1
    Keywords: brain ; EXPOSURE ; LONG-TERM ; POPULATION ; RISK ; meningioma ; HEALTH ; NUMBER ; COUNTRIES ; HEAD ; case-control study ; GLIOMA ; methods ; pooled analysis ; INCREASED RISK ; CANCER-RISK ; INTERNATIONAL CASE-CONTROL ; brain tumours ; CORDLESS TELEPHONES ; mobile phones ; SELECTION BIAS ; PHONE USE ; CELLULAR TELEPHONES ; NONDIFFERENTIAL MISCLASSIFICATION ; radiofrequency fields
    Abstract: Methods An interview-based case-control study with 2708 glioma and 2409 meningioma cases and matched controls was conducted in 13 countries using a common protocol. Results A reduced odds ratio (OR) related to ever having been a regular mobile phone user was seen for glioma [OR 0.81; 95% confidence interval (CI) 0.70-0.94] and meningioma (OR 0.79; 95% CI 0.68-0.91), possibly reflecting participation bias or other methodological limitations. No elevated OR was observed 〉= 10 years after first phone use (glioma: OR 0.98; 95% CI 0.76-1.26; meningioma: OR 0.83; 95% CI 0.61-1.14). ORs were 〈 1.0 for all deciles of lifetime number of phone calls and nine deciles of cumulative call time. In the 10th decile of recalled cumulative call time, 〉= 1640 h, the OR was 1.40 (95% CI 1.03-1.89) for glioma, and 1.15 (95% CI 0.81-1.62) for meningioma; but there are implausible values of reported use in this group. ORs for glioma tended to be greater in the temporal lobe than in other lobes of the brain, but the CIs around the lobe-specific estimates were wide. ORs for glioma tended to be greater in subjects who reported usual phone use on the same side of the head as their tumour than on the opposite side. Conclusions Overall, no increase in risk of glioma or meningioma was observed with use of mobile phones. There were suggestions of an increased risk of glioma at the highest exposure levels, but biases and error prevent a causal interpretation. The possible effects of long-term heavy use of mobile phones require further investigation
    Type of Publication: Journal article published
    PubMed ID: 20483835
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  • 2
    Keywords: CANCER ; Germany ; COMMON ; INFORMATION ; EXPOSURE ; HISTORY ; POPULATION ; RISK ; RISKS ; meningioma ; TISSUE ; IMPACT ; RISK-FACTORS ; TISSUES ; tumour ; FREQUENCY ; FIELD ; FREQUENCIES ; HEALTH ; DESIGN ; NUMBER ; risk factors ; COUNTRIES ; SWEDEN ; FRANCE ; NETHERLANDS ; case-control studies ; study design ; AUSTRALIA ; FINLAND ; case control study ; case-control study ; RE ; BRAIN-TUMORS ; INCREASE ; GLIOMA ; RECALL ; GLAND ; case control studies ; methods ; CELLULAR-TELEPHONE USE ; RISK-FACTOR ; CANCER-RISK ; E ; carcinogenic ; INCREASES ; case control ; acoustic neuroma ; brain tumours ; mobile phone ; MOBILE PHONE USE ; SETUP ; acoustic neurinoma ; benign tumours ; case-control ; CORDLESS TELEPHONES ; FIELDS ; mobile phones ; parotid gland tumours ; SELECTION BIAS
    Abstract: The very rapid worldwide increase in mobile phone use in the last decade has generated considerable interest in the possible health effects of exposure to radio frequency (RF) fields. A multinational case-control study, INTERPHONE, was set-up to investigate whether mobile phone use increases the risk of cancer and, more specifically, whether the RF fields emitted by mobile phones are carcinogenic. The study focused on tumours arising in the tissues most exposed to RF fields from mobile phones: glioma, meningioma, acoustic neurinoma and parotid gland tumours. In addition to a detailed history of mobile phone use, information was collected on a number of known and potential risk factors for these tumours. The study was conducted in 13 countries. Australia, Canada, Denmark, Finland, France, Germany, Israel, Italy, Japan, New Zealand, Norway, Sweden, and the UK using a common core protocol. This paper describes the study design and methods and the main characteristics of the study population. INTERPHONE is the largest case-control study to date investigating risks related to mobile phone use and to other potential risk factors for the tumours of interest and includes 2,765 glioma, 2,425 meningioma, 1,121 acoustic neurinoma, 109 malignant parotid gland tumour cases and 7,658 controls. Particular attention was paid to estimating the amount and direction of potential recall and participation biases and their impact on the study results
    Type of Publication: Journal article published
    PubMed ID: 17636416
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  • 3
    Keywords: brain ; Germany ; EXPOSURE ; POPULATION ; RISK ; HEALTH ; case-control studies ; CENTERS ; SELECTION ; brain neoplasms ; PREVALENCE ; INSIGHTS ; case-control study ; BRAIN-TUMORS ; GLIOMA ; epidemiological methods ; acoustic neuroma ; SELECTION BIAS ; INTERPHONE-STUDY-GROUP ; BRAIN-TUMOR ; RESPONSE RATES ; Cellular Phones ; Refusal to Participate ; REPORTING PARTICIPATION
    Abstract: PURPOSE: To quantitatively assess the impact of selection bias caused by nonparticipation in a multinational case-control study of mobile phone use and brain tumor. METHODS: Non-response questionnaires (NRQ) were completed by a sub-set of nonparticipants. Selection bias factors were calculated based on the prevalence of mobile phone use reported by nonparticipants with NRQ data, and on scenarios of hypothetical exposure prevalence for other nonparticipants. RESULTS: Regular mobile phone use was reported less frequently by controls and cases who completed the NRQ (controls, 56%; cases, 50%) than by those who completed the full interview (controls, 69%; cases, 66%). This relationship was consistent across study centers, sex, and age groups. Lower education and more recent start of mobile phone use were associated with refusal to participate. Bias factors varied between 0.87 and 0.92 in the most plausible scenarios. CONCLUSIONS: Refusal to participate in brain tumor case-control studies seems to be related to less prevalent use of mobile phones, and this could result in a downward bias of around 10% in odds ratios for regular mobile phone use. The use of simple selection bias estimation methods in case-control studies can give important insights into the extent of any bias, even when nonparticipant information is incomplete
    Type of Publication: Journal article published
    PubMed ID: 19064187
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  • 4
    ISSN: 1617-4623
    Keywords: Nicotiana sylvestris ; Cytoplasmic male sterility ; Mitochondrial DNA deletion ; Substoichiometric sequences ; Mitochondrialnad7 gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract InNicotiana sylvestris, two cytoplasmic male sterile (CMS) mutants obtained by protoplast culture show abnormal developmental features of both vegetative and reproductive organs, and mitochondrial gene reorganization following homologous recombination between 65 bp repeated sequences. A mitochondrial region of 16.2 kb deleted from both CMS mutants was found to contain the last two exons of thenad7 gene coding for a subunit of the mitochondrial respiratory chain complex I, which is encoded in the nucleus in fungi and animals but was recently found to be encoded by the mitochondrial genome in wheat. Although theN. sylvestris nad7 gene shows strong homology with its wheat counterpart, it contains only three introns instead of four. Polymerase chain reaction (PCR) experiments indicated that the parental gene organization, including the completenad7 gene, is probably maintained at a substoichiometric level in the CMS mutants, but this proportion is too low to have a significant physiological role, as confirmed by expression studies showing the lack of detectable amounts of the NAD7 polypeptide. Consequently, absence of NAD7 is not lethal to plant cells but a deficiency of complex I could be involved in the abnormal CMS phenotype.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1617-4623
    Keywords: Protoplast culture ; Nuclear male sterility ; Mitochondrial DNA recombination ; Substoichiometric molecules ; Nicotiana sylvestris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary ANicotiana sylvestris plant regenerated from protoplast culture was found to be mutated in both the mitochondrial (mt) and nuclear genomes. The novel mt DNA organization, called U, is due to the amplification of recombinant substoichiometric DNA sequences that preexist in the parent line. The recombination event involves two 404 by repeats, which hybridize to a 2.1 kb transcript. Although the sequence of both repeats was not altered by the recombination, an additional transcript of 2.5 kb was detected in U mitochondria. In addition to this mitochondrial reorganization, the protoclone carried a recessive nuclear mutation conferring male sterility (ms4). A possible role ofms4 in the appearance of the U mt DNA organization was investigated by introducing this gene into normalN. sylvestris cytoplasm. No mt DNA change could be found in homozygousms4/ms4 plants of the F2 generation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1617-4623
    Keywords: Protoplast culture ; Nuclear and cytoplasmic male sterility ; Mitochondrial DNA and proteins ; Nicotiana sylvestris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Male sterile plants appeared in the progeny of three fertile plants obtained after one cycle of protoplast culture from a fertile botanical line and two androgenetic lines ofNicotiana sylvestris. These plants showed the same foliar and floral abnormalities as the cytoplasmic male sterile (cms) mitochondrial variants obtained after two cycles of culture. We show that male sterility in these plants is controlled by three independent nuclear genes,ms1, ms2 andms3, while no changes can be seen in the mitochondrial genome. However, differences were found between thein organello mitochondrial protein synthesis patterns of male sterile and parent plants. Two reproducible changes were observed: the presence of a new 20 kDa polypeptide and the absence of a 40 kDa one. Such variations were described previously in mitochondrial protein synthesis patterns of the cms lines. Fertile hybrids of male sterile plants showed normal synthesis patterns. The male sterile plants are thus mutated in nuclear genes involved in changes observed in mitochondrial protein synthesis patterns.
    Type of Medium: Electronic Resource
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