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  • Springer eBooks  (3)
  • Animal Behaviour  (1)
  • Forestry  (1)
  • Nicotine  (1)
  • 2010-2014  (3)
  • 1965-1969  (1)
  • 2010-2014  (3)
  • 1965-1969  (1)
  • 1
    Keywords: Life sciences ; Biotechnology ; Agriculture ; Forests and forestry ; Plant breeding ; Renewable energy sources ; Sustainable development ; Life sciences ; Agriculture ; Forestry ; Plant Breeding/Biotechnology ; Renewable and Green Energy ; Sustainable development ; Biotechnology ; Springer eBooks
    Pages: : digital
    ISBN: 9783642134401
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  • 2
    Keywords: Medicine ; Gynecology ; Endocrinology ; Reproductive Medicine ; Urology ; Medicine & Public Health ; Gynecology ; Endocrinology ; Reproductive Medicine ; Urology/Andrology ; Springer eBooks
    Pages: : digital
    ISBN: 9781441984562
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  • 3
    Keywords: Medicine ; Oncology ; Human Genetics ; Biomedicine ; Human Genetics ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Preface -- Introduction -- Non-mammalian hematopoiesis -- Epigenetic mechanisms regulating mammalian hematopoietic stem cell development and function -- Epigenetic and transcriptional mechanisms regulating cell fate decisions and blood cell lineage development -- Epigenetic control of immune cell function -- Subject index
    Abstract: In recent years, great progress has been made in the identification of the molecular players involved in the epigenetic control of gene expression during development. The work of many laboratories has established that regulating the interplay of transcription factors with chromatin components is the major driver of cellular differentiation. Because of their single cell nature and ease of purification, much of what we have learnt about these processes in animals has been delivered based on cellular models within the hematopoietic system. The blood cell system evolved from a few simple cell types in more primitive organisms that provide oxygen transport and carry out phagocytosis into the complex hematopoietic system of mammals, containing many specialized cells types with vastly different functions, such as B cells, T cells, granulocytes, macrophages, erythrocytes, and megakaryocytes. This book describes the intricate processes involved in the development of blood cells across a range of organisms from drosophila and fish at one end, and mammals at the other end. It contains individual chapters devoted to describing the epigenetic and transcriptional mechanisms regulating hematopoiesis in the different organisms and orchestrating the differentiation of a wide variety of cell types. Different chapters describe the function of lymphocytes, macrophages and red blood cells and the molecular players, i.e. transcription factors and the epigenetic regulatory machinery driving their differentiation. Most importantly, the book not only describes normal processes, such as the rearrangements of antigen receptor genes, and the regulation of genes by various mechanisms such as DNA methylation, but also outlines what happens when these processes function abnormally to precipitate diseases such as leukemia and immune disorders
    Pages: XIII, 416 p. 49 illus. in color. : online resource.
    ISBN: 9783642451980
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  • 4
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Animal Behaviour ; Nicotine ; Physostigmine ; Motor Activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats of 3 strains were observed at regular intervals and their activity was recorded using four categories of behaviour-rearing, moving, grooming and immobile. Strain differences in control activity were found. Nicotine and physostigmine reduced the activity of the more active rats and increased that of the less active animals. Rearing behaviour was particularly susceptible to depression by both drugs. The similarity of effect of the two drugs supports the hypothesis that one of the actions of nicotine in the brain is the release of acetylcholine.
    Type of Medium: Electronic Resource
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