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  • 3H  (1)
  • AC-ECD  (1)
  • Noradrenaline release  (1)
  • 6-Dichloro-2-acetamidophenyl acetate; 5
  • Springer  (3)
  • Munksgaard International Publishers
  • 1985-1989  (3)
Collection
Publisher
  • Springer  (3)
  • Munksgaard International Publishers
Years
Year
  • 1
    ISSN: 1432-1912
    Keywords: Dopamine release ; Guanine nucleotide binding proteins ; Noradrenaline release ; Opioid µ-, δ-, and κ-receptors ; Pertussis toxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Opioid agonists selective for µ-, δ-, and κ-receptors are all capable of regulating the stimulated release of noradrenaline from three terminal fields (cortex, hippocampus, and cerebellum) of the noradrenergic projections from locus coeruleus in the guinea pig brain. Intracerebroventricular injections of pertussis toxin abolished the ability of a µ-selective agonist and of a δ-selective agonist to inhibit stimulated noradrenaline release, but left unaffected the concentration-related inhibition of NE release by a κ agonist. Thus, µ- and δ-receptors have been shown to be coupled to their effector systems in these noradrenergic neurons via guanyl nucleotide binding proteins (G proteins) which are sensitive to pertussis toxin, while κ-receptors in the same neurons appear to be coupled through a different mechanism which is significantly less sensitive to pertussis toxin. In contrast to opioid receptor regulation of noradrenaline release in guinea pig hippocampus, µ-, but not δ- or κ-agonists are capable of regulation of stimulated noradrenaline release from rat hippocampus and cortex, and κ-, but not µ- or δ-agonists are capable of inhibiting the stimulated release of dopamine from rat striatum and cortex. Pertussis toxin injections significantly attenuated µ-agonist inhibition of noradrenaline release, but had no effect on the ability of a κ-selective agonist to regulated dopamine release, confirming the insensitivity of the κ-receptor-effector coupling system to pertussis toxin.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1436-5073
    Keywords: ionization topography ; 3H ; 63Ni ; electron capture detector
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The ion-pair generation rate (ionization topography) in plasmas from63Ni and particularly Ti3H4 foils, as used in electron capture detectors, was measured at room temperature using large, parallel plates of low backscattering ability in nitrogen gas of varying density. For one atmosphere pressure, the fall-off of ion pair formation as calculated from the exponential region equalsN 0·e −0.19d for63Ni andN 0·e −1.4d for3H (whereN 0 is the initial ionization rate immediately adjacent to the foil andd is the distance from the foil in mm). The experimentally measured half ranges (distances from the foil within which 50% of all possible ion pairs are created) are 2.7 mm for63Ni and 0.27 mm for3H. The half ranges calculated from the exponential region where there is less interference from electron backscattering, are 3.7 and 0.5 mm, respectively. The latter values are considered closer to the “true”, unimpeded ionization topography near planar63Ni and3H foils.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Microchimica acta 96 (1988), S. 11-26 
    ISSN: 1436-5073
    Keywords: electron capture detector (ECD) ; electron oscillation ; AC-ECD ; argon-methane ; non-homogeneous ECD kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The oscillation of electrons—as driven by AC polarization—can be used to extract a high-sensitivity signal from a conventional electron capture detector. For example, hexachloroethane was detected at a hypercoulometric ratio of 2.0 F/mol, down to ca. 60 fg/s (S/N=3) and with a linear range in excess of two orders of magnitude. The change in carrier gas from nitrogen to argon-methane produced the expected order-of-magnitude increase in optimum oscillation frequency. Anab initio simulation of potentials and ion populations in a heterogeneous electron capture system under a high-frequency AC regime provided further insight into the detector's mechanism: Hypercoulometric response is mainly caused by increased cation-electron recombination in the plasma region, owing to a decreased field gradient and an increased cation concentration.
    Type of Medium: Electronic Resource
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