Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
The interaction of arsenic and selenium compounds on the metabolism of these elements in golden hamsters was studied. Golden hamsters were divided into three groups and administered sodium selenite (Na2SeO3), sodium arsenite (NaAsO2) and Na2SeO3 with NaAsO2, respectively, by a single Subcutaneous injection of 25 m̈mol kg-1 body weight as As or Se (arsenic and selenium were calculated as weight of elemental arsenic and selenium). Selenium and arsenic metabolites were determined by high-performance liquid chromatography-graphite furnace atomic absorption spectrometry (HPLC-GFA AA) and gas chromatography (GC). The results show (1): About 10% by weight of the given dose of selenium was excreted in expiration air as dimethylselenide (Me2Se) during 12 h after administration of Na2SeO3. Excretion of dimethylselenide with the respiratory air was inhibited by administration of Na2SeO3 simultaneously with NaAsO2. (2) Giving Na2SeO3 plus NaAsO2 had no appreciable effect on the excretion of the trimethylselenonium ion (Me3Se+) into the urine and the feces. (3) Giving Na2SeO3 plus NaAsO2 increaed the excretion into the feces of an insoluble unknown-structure selenium compound, the proportion of which was 10.9% by weight of the given dose of selenium. (4) Giving NaAsO2 plus Na2SeO3 decreased the excretion of dimethylarsinic acid (Me2AsOOH) and inorganic arsenic into the urine during 120 h after the administration of the reagents, the decreased amount being 5.3% (dimethylarsinic acid) and 7.7% (inorganic arsenic) of the given dose of arsenic, respectively. (5) Giving NaAsO2 plus Na2SeO3 increased the excretion into feces of insoluble unknown-structure arsenic compound and inorganic arsenic, the increased amounts being 10.6% and 7.0% of the given dose of arsenic, respectively. (6) Giving NaAsO2 plus Na2SeO3 decreased the excretion into feces of extractable unknown-structure arsenic compound, and the decreased amount was 4.9% of the given dose of arsenic. (7) It made little difference to the excretion of monomethylarsonic acid [MeAsO(OH)2] into urine and feces and of dimethylarsinic acid (Me2AsOOH) into feces whether NaAsO2 was administered alone or with Na2SeO3.
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