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  • 1
    ISSN: 1432-2307
    Keywords: Thyroid ; C Cells ; Peptides ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary C cells of thyroid are known to express a variety of products beside calcitonin. These include the peptides PDN21 (katacalcin), calcitoningene related peptide (CGRP), bombesin and somatostatin. The expression of these products has been investigated by immunohistochemistry of thyroid tissue in six age ranges from fetal to late adult life. PDN 21 was found to have co-expression with calcitonin. CGRP and bombesin both demonstrated an age-related increase in numbers and intensity of cells stained. Somatostatin immunoreactivity was limited to small numbers of cells.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0568
    Keywords: Dogfish ; Peptides ; Immunocytochemistry ; Gastrointestinal ; Co-localisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The gastrointestinal tract of cartilaginous fishes, like that of higher vertebrates, is known to contain endocrine cells and nerves immunoreactive for a wide variety of peptides, some of which have been structurally characterised. Since we have found that substance P-, bombesin-and peptide histidine isoleucine-like immunoreactivities are similarly distributed in the endocrine cells of the dogfish pyloric stomach, we have tried to establish whether any of these peptides are co-localised. The cells were compared in thin serial sections with both ligh-and electron microscopical immunocytochemistry. Double immunolabelling was also used to show two immunoreactive peptides in the same tissue section. Further characterisation of the immunoreactivity was attempted by preabsorbing the antibodies with various peptides or synthetic fragments of peptide molecules. Immunoreactivity for all three peptides was frequently present in the same cells, whereas antibodies to other peptides such as gastrin and somatostatin marked different cells. Electron microscopy indicated that all the secretory granules in three morphologically different cell types reacted with antibodies to all three peptides. Dual localisation of unrelated peptides in endocrine cells or nerves is established in many cases, but triple localisation is as yet unusual. The immunoreaction for bombesin-like peptides is different in endocrine cells and nerves, indicating that dogfish bombesin may be present in two forms, in agreement with biochemical evidence.
    Type of Medium: Electronic Resource
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