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  • 1
    Keywords: RISK ; FUNCTIONAL ANNOTATION ; BINDING-SITES ; GENOME-WIDE ASSOCIATION ; MICRORNA EXPRESSION ; PARKINSON-DISEASE ; GENETIC-VARIANTS ; SITE POLYMORPHISMS ; COMMON INVERSION ; MAPT REGION
    Abstract: Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3' untranslated region at putative microRNA (miRNA)-binding sites represent functional targets that influence EOC susceptibility. Here, we evaluate the association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and EOC risk in 18,174 EOC cases and 26,134 controls from 43 studies genotyped through the Collaborative Oncological Gene-environment Study. We identify several miRSNPs associated with invasive serous EOC risk (odds ratio=1.12, P=10(-8)) mapping to an inversion polymorphism at 17q21.31. Additional genotyping of non-miRSNPs at 17q21.31 reveals stronger signals outside the inversion (P=10(-10)). Variation at 17q21.31 is associated with neurological diseases, and our collaboration is the first to report an association with EOC susceptibility. An integrated molecular analysis in this region provides evidence for ARHGAP27 and PLEKHM1 as candidate EOC susceptibility genes.
    Type of Publication: Journal article published
    PubMed ID: 23535648
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  • 2
    Keywords: CELLS ; EXPRESSION ; carcinoma ; RISK ; GENE ; leukemia ; MYC ; GENOME-WIDE ASSOCIATION ; NEBULETTE ; 19P13
    Abstract: Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the UK. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. We performed follow-up genotyping in 18,174 individuals with EOC (cases) and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 x 10(-9)) and 10p12 (rs1243180, P = 1.8 x 10(-8)) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 x 10(-10)). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer.
    Type of Publication: Journal article published
    PubMed ID: 23535730
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  • 3
    Keywords: RISK ; PROSTATE-CANCER ; LOCI ; GENOME-WIDE ASSOCIATION ; COMMON VARIANTS ; CLEAR-CELL CARCINOMA ; MODY
    Abstract: HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR) = 1.13, P = 3.1 x 10(-10)) and clear cell (rs11651755 OR = 0.77, P = 1.6 x 10(-8)) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B, primarily present in clear cell tumours, coincides with a CpG island methylator phenotype affecting numerous other promoters throughout the genome. Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes. These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes.
    Type of Publication: Journal article published
    PubMed ID: 23535649
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 236 (1938), S. 310-319 
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1Es werden mehrere Proben von Tetracalciumaluminiumferrit (4 CaO·Al2O3 · Fe2O3) hergestellt und ihre Lösungswärmen in einem Überschuß von HC1·20 H2,/O bestimmt.2Die Lösungswärme beträgt bei 20°C für lg 4CaO·Al2O3·Fe2O3 2217 int. Joule (530,5 kcal20°) und für ein Mol 1077, 4 kj. (257,s kcal20°).
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 30 (1984), S. 583-593 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A simple particle model is used to interpret differential thermogravimetric data taken on the gasification of coal/char with CO2, H2 and H2O. The model takes into account the major physical factors which influence the gasification rate, viz., the changing magnitudes of surface area, porosity, activation energy and effective diffusivity during gasification. Specific reaction rate constants based on surface area and activation energies are extracted from the data. Practical criteria for regimes of reaction rate and diffusion control and for particle isothermality are developed. For isothermal particles at low classical Thiele moduli, the data can be correlated with only one parameter, which has a simple physical interpretation.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 2 (1956), S. 148-152 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An investigation using the hexone-water system was made of flooding in a 1-in.-diam. ten-plate pulse column. An analysis of column operation led to the derivation of an equation for predicting conditions of inadequate pulsation and for establishing the amount of liquid recycled under any operating conditions.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 17 (1988), S. 241-244 
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The use of fast atom bombardment mass spectrometry has been demonstrated for the qualitative analysis of mixtures of dansylated amines and compared with high-performance liquid chromatography for the quantification of some individual amines from meat products.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Tubings extruded from one batch of polyvinylchloride resin at five temperatures ranging from 110 to 205°C were tested for thrombogenicity in the saphenous vein and aorta of sheep. There was more thrombus in both the vein and aorta on tubings extruded at lower temperatures. The surface areas of renal infarction were smaller when lower temperature tubings were inserted into the aorta. Scanning electron microscopy showed that lower extrusion temperatures caused greater roughness on the tubings. This greater roughness was confirmed by roughness measurements. It is suggested that the association which has been demonstrated between roughness and thrombus formation might be due to the degree of adhesion of the thrombus to the surface rather than to differences in thrombogenicity.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Eight acrylic bone cement products were examined according to the methods set out in three published performance standards, viz., Australian Standard 2265 Part 1, 1979, ASTM specification F451-76, and the ISO specification 5833/1, 1979. In addition, chemical analyses were carried out by GC, NMR, and IR spectroscopy as well as refractive index measurement, all to establish the main constituent of the products. All the products compiled to the physical, compositional, and sterility requirements of AS 2265. However, all but one sample failed to comply with the solubility requirements of ASTM F451-76. Also, none of the samples compiled with the doughing time requirements of ISO 5833/1. On further analysis, the results suggest that the water solubility and sorption requirements of ASTM F451-76 are restrictive and that the ISO doughing time test methodology requires modification. Various degrees of noncompliance to the requirement of all three specifications were noted on the labeling and in the information content of product inserts. Two additional clauses on mixing tools and radiopacity have been suggested for incorporation into the above standards.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Quantifiable frozen-stress photoelastic techniques were used to analyze stresses induced in mandibular models by a conventional free-end saddle removable partial denture. Four quasi-anatomical mandibular models were constructed for processing, together with their respective calibration specimens, through identical time/temperature stress-freezing cycles. After processing and slicing, an unloaded control model demonstrated some low-order fringes adjacent to the coronal third of the abutment tooth roots, but was otherwise stress free. A lower bilateral free-end saddle partial denture was constructed and fitted in turn to each of the remaining three models. Each denture/model combination was then loaded and processed through a stress-freezing cycle. After processing, 6-mm slices were cut from selected regions for analysis for the presence of stresses. Using a polariscope with circular polarized, monochromatic light, values for maximum shear stress were calculated at selected points in the slices taken from the three loaded models. Variations up to 28% of the mean were obtained for the three experimental models as compared with the consistent results for the material fringe values obtained from the calibration specimens. The study pointed out the problems involved in using photoelastic stress analysis on complicated anatomical models. The interpretation of the results from such studies should be approached with caution.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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