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  • RISK  (2)
  • TISSUE  (2)
  • 1
    Keywords: radiotherapy ; Germany ; LUNG ; imaging ; LUNG-CANCER ; RISK ; TISSUE ; NUCLEAR-MEDICINE ; radiation ; PATIENT ; INDEX ; TARGET ; chemotherapy ; NORMAL TISSUE ; nuclear medicine ; mesothelioma ; PLEURAL MESOTHELIOMA ; IMRT ; FEASIBILITY ; MANAGEMENT ; NECK-CANCER ; radiology ; ONCOLOGY ; methods ; NUCLEAR ; MODULATED RADIATION-THERAPY ; MEDICINE ; comparison ; PENCIL BEAM ; TOMOTHERAPY ; TREATMENT PLANS ; MPM ; helical tomotherapy ; EXTRAPLEURAL PNEUMONECTOMY ; HEIDELBERG EXPERIENCE ; HEMITHORACIC RADIATION ; step-and-shoot IMRT
    Abstract: Purpose: To evaluate the potential of helical tomotherapy in the adjuvant treatment of malignant pleural mesothelionna and compare target homogeneity, conformity and normal tissue dose with step-and-shoot intensity-modulated radiotherapy. Methods and materials: Ten patients with malignant pleural mesothelioma who had undergone neoadjuvant chemotherapy with cisplatin and permetrexed followed by extrapleural pneumonectomy (EPP) were treated in our department with 54 Gy to the hemithorax delivered by step-and-shoot IMRT. A planning comparison was performed by creating radiation plans for helical tomotherapy. The different plans were compared by analysing target homogeneity using the homogeneity indices HImax and HImin and target conformity by using the conformity index CI95. To assess target coverage and normal tissue sparing TV90, TV95 and mean and maximum doses were compared. Results: Both modalities achieved excellent dose distributions while sparing organs at risk. Target coverage and homogeneity could be increased significantly with helical tomotherapy compared with step-and-shoot IMRT. Mean dose to the contralateral lung could be lowered beyond 5 Gy. Conclusions: Our planning study showed that helical tomotherapy is an excellent option for the adjuvant intensity-modulated radiotherapy of MPM. It is capable of improving target coverage and homogeneity. (c) 2007 Elsevier Ireland Ltd. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 18207597
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  • 2
    Keywords: OPTIMIZATION ; CANCER ; radiotherapy ; tumor ; carcinoma ; THERAPY ; SYSTEM ; VOLUME ; RISK ; TISSUE ; PATIENT ; primary ; REDUCTION ; TISSUES ; FIELD ; PROTON ; TARGET ; EXPERIENCE ; RADIATION-THERAPY ; chemotherapy ; SWEDEN ; HEAD ; INTENSITY-MODULATED RADIOTHERAPY ; NORMAL TISSUE ; treatment planning ; NECK TUMORS ; IMRT ; proton therapy ; THERAPIES ; QUALITY-OF-LIFE ; methods ; 3D ; technique ; ENGLAND ; PHOTON ; IMPT ; Protons ; FIELDS ; HEARING-LOSS
    Abstract: Background: The aim of this treatment planning study was to investigate the potential advantages of intensity-modulated (IM) proton therapy (IMPT) compared with IM photon therapy (IMRT) in nasopharyngeal carcinoma (NPC). Methods: Eight NPC patients were chosen. The dose prescriptions in cobalt Gray equivalent (GyE) for gross tumor volumes of the primary tumor (GTV-T), planning target volumes of GTV-T and metastatic (PTV-TN) and elective (PTV-N) lymph node stations were 72.6 Gy(E), 66 Gy(E), and 52.8 Gy(E), respectively. For each patient, nine coplanar fields IMRT with step-and-shoot technique and 3D spot-scanned three coplanar fields IMPT plans were prepared. Both modalities were planned in 33 fractions to be delivered with a simultaneous integrated boost technique. All plans were prepared and optimized by using the research version of the inverse treatment planning system KonRad (DKFZ, Heidelberg). Results: Both treatment techniques were equal in terms of averaged mean dose to target volumes. IMPT plans significantly improved the tumor coverage and conformation (P 〈 0.05) and they reduced the averaged mean dose to several organs at risk (OARs) by a factor of 2-3. The low-to-medium dose volumes (0.33-13.2 Gy(E)) were more than doubled by IMRT plans. Conclusion: In radiotherapy of NPC patients, three-field IMPT has greater potential than nine-field IMRT with respect to tumor coverage and reduction of the integral dose to OARs and nonspecific normal tissues. The practicality of IMPT in NPC deserves further exploration when this technique becomes available on wider clinical scale
    Type of Publication: Journal article published
    PubMed ID: 18218078
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