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  • 1
    ISSN: 1613-9674
    Keywords: Radiation therapy ; Bone metastases ; Head and neck cancer ; Pain relief
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the efficacy of radiation therapy for pain relief of bone metastases from head and neck cancer, a total of 22 patients with head and neck cancer with 30 metastatic bone lesions treated by radiation therapy at the Cancer Institute Hospital were analyzed. These patients were given a dose of 20 to 50 Gy in 10 to 25 fractions using liniac X-ray or electron beam and were divided into two groups. Group A consisted of 10 patients with tongue cancer (tongue cancer group), and group B consisted of 12 patients other than with tongue cancer (non-tongue cancer group). In group A, of the 6 metastatic lesions treated with over 30 Gy, 17% achieved CR (complete pain relief for more than 3 months), 33% showed PR (over 50% extent pain relief), and 50% NC. While, in group B, of the 17 lesions 35% showed Cr, 53% PR and 12% NC. There was a significant difference in the response rate (50% vs 88%, P〈0.01) of pain relief between the osseous metastases from tongue cancer group and the non-tongue cancer group, although further prospective studies are necessary to elucidate the radiosensitivity of bone metastases in terms of the histologic difference in head and neck cancer patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1437-7772
    Keywords: Key words Patterns of Care Study ; Cervix cancer ; Radiation therapy ; Elderly ; Process survey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. To improve the quality of radiation oncology in Japan, a Patterns of Care Study (PCS), a quality assurance program widely known in the United States, was introduced to Japan. In this study, the process, including work-up and treatment for uterine cervix cancer patients, was investigated to show nationwide variation by age. Methods. From July 1996 through February 1997, PCS extramural audits were performed for 29 institutions nationwide. Medical charts for 432 patients with uterine cervix cancer treated between 1992 and 1994 were reviewed based on the PCS data format used in the US. The processes of radiation therapy for these patients were compared in two age groups – those aged ≥75 years (n = 132) and those aged 〈75 years (n = 300). Results. There were significant differences by age group in medical background, indicating the fragility of the elderly and a relatively higher incidence of early-stage disease in the elderly by patient selection. Lower pelvic radiation doses were used for the elderly with advanced stage disease. There were no significant differences in unplanned breaks in external irradiation between the two age groups. Brachytherapy was used less commonly in the elderly group than in younger group (P = 0.0187). The dose range for brachytherapy did not show any significant difference between the two groups. Preliminary survival rates for the elderly were similar to those for the younger group. Conclusion. Radiation therapy was found to play an important role in the treatment of uterine cervix cancer in elderly as well as younger patients.
    Type of Medium: Electronic Resource
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