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  • Chemistry  (5)
  • Rat  (4)
  • Blood viscosity  (3)
  • 1
    ISSN: 1432-1440
    Keywords: Blutviskosität ; Hyperlipoproteinämie ; Clofibrattherapie ; Blood viscosity ; Hyperlipoproteinemia ; Clofibrate therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In patients with primary hyperlipoproteinemia (23 patients type II a and II b, 13 patients type IV), changes in lipoprotein concentrations (lipid fraction), fibrinogen concentrations, in kinematic serum and plasma viscosity (determined by means of a capillary viscosimeter) and changes in relative apparent viscosity at shear rate 46 s−1 and 115 s−1 (determined by means of a plate-cone-viscosimeter) were measured before and after a clofibrate therapy (2 × 1 g/day) lasting for 7 to 9 weeks. Serum and plasma viscosity was lowered significantly in both types II and IV. The apparent viscosity decreased at shear rate 46 s−1 in type IV, whereas it remained unchanged in type II. Moreover, there exists a qualitative correlation between changes in serum viscosity and changes in lipoprotein concentration. Fibrinogen concentration remained unaltered.
    Notes: Zusammenfassung Bei Patienten mit primärer Hyperlipoproteinämie (23 Patienten Typ II a und b, 13 Patienten Typ IV) wurden die Veränderungen der Lipoproteinkonzentrationen (Lipidanteile), der Fibrinogenkonzentrationen, der kinematischen Serum- und Plasmaviskosität (im Kapillar-Viskosimeter) sowie der relativen scheinbaren Viskosität (Platte-Kegel-Viskosimeter) bei Schergrad 46 s−1 und 115 s−1 vor und nach einer 7- bis 9wöchigen Clofibrattherapie (2 × 1 g/die) gemessen. Art und Ausmaß der Lipoproteinveränderungen entsprachen den Erwartungen. Die Serum- und Plasmaviskosität wurde bei beiden Typen signifikant gesenkt. Eine signifikante Minderung der scheinbaren Viskosität konnte bei dem Schergrad 46 s−1 für den Typ IV gesichert werden, wohingegen der Typ II unbeeinflußt blieb. Weiterhin konnte ein enger qualitativer Zusammenhang zwischen den Änderungen der Lipoproteinkonzentrationen und den Änderungen der Serumviskosität gezeigt werden. Veränderungen der Fibrinogenkonzentration waren nicht zu sichern.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Hyperlipoproteinemia ; Blood viscosity ; Red cell deformability ; Hyperlipoproteinämie ; Blutviskosität ; Erythrozytenflexibilität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Patienten mit einer primären Hyperlipoproteinämie (Typ IIa, IV, IIb) wurde mit einem Ubbelohde-Kapillarviskosimeter, mit einem Wells-Brookfield-Platte-Kegel-Viskosimeter und einem Nuklepore-Filtrationsgerät die Serum- und Plasmaviskosität, scheinbare und relative scheinbare Blutviskosität sowie die Erythrozytenflexibilität bestimmt. Alle Meßgrößen unterschieden sich signifikant von denen eines normolipidämischen Kontroll-Kollektivs: Die Viskositätswerte waren beim Typ IIb am stärksten, beim Typ IIa am schwächsten erhöht, während die Erythrozytenflexibilität unabhängig vom Typ vermindert war.
    Notes: Summary In patients with primary hyperlipoproteinemia (types IIa, IV, IIb) we determined by means of a Wells-Brookfield plateconeviscometer and an Ubbelohde capillary-viscometer the serum-, plasma-, apparent and relative apparent blood viscosity as well as the red cell deformability with a filtration technique. All parameters were found to be significantly changed in comparison to those of a normolipidemic control-group: The viscosity values of type IIb showed the greatest increase and of type IIa the smallest, while the red cell deformability was reduced in all types to the same degree.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0878
    Keywords: Somatostatin ; Luliberin (LRF) ; Intercellular clefts (brain) ; Immunoreactive glia-like cells ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary With the aid of electron microscopic immunocytochemistry following the application of antisera against somatostatin and luliberin (LRF), a labeling of the intercellular clefts in different areas of the brain was observed. This labeling is especially conspicuous near the basal pole of the cuboidal ependymal cells, but is also generally present in all regions containing neurohormone-producing perikarya or their processes (for example, the preoptic area, the basal ganglia and the cortex). Furthermore, in all these regions displaying labeled intercellular clefts, glialike cells and sparsely ciliated ependymal cells are found, the secondary lysosomes of which exhibit an immunoreactivity resembling that observed in the intercellular clefts. As sources of the immunoreactive material the following possibilities are discussed: (i) perikarya producing somatostatin or LRF, situated in the wall of the third ventricle and sending fibers between the cuboidal ependymal cells, (ii) hypothalamic and extrahypothalamic projections of both peptidergic systems, and (iii) in the case of somatostatin, immunoreactive perikarya in the cortex.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0365-9631
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0365-9631
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Rising the molecular mass of acrylonitrile polymers results in diminishing the maximum draft value and simultaneously decreasing the drawing ratio in fibre formation by the wet spinning method. The maximum drawing ratio of as-spun filaments decreases with increasing molecular mass and with rising the drawing ratio, too. With comparable conditions of fibre formation, filaments from polymers with higher molecular mass show a much lower degree of orientation in spite of similar tear resistance. Obtaining high-performance properties in wet spun filaments requires a new concept for coagulation which includes as well as polymer immanent factors and peculiarities of the process.
    Notes: Bei der Bildung von Fäden aus Acrylnitrilpolymeren nach dem Naßspinnprinzip bewirkt eine Erhöhung der Molmasse der Polymere eine Herabsetzung des maximal erreichbaren Düsenabzuges bei gleichzeitig geringerem Düsenverzugsverhältnis. Der maximale Reckgrad der ersponnenen Fäden sinkt mit steigender Molmasse und nimmt darüber hinaus mit steigendem Düsenverzug ab. Unter vergleichbaren Bedingungen hergestellte Fäden besitzen bei höherer Molmasse trotz gleicher erzielter Festigkeiten einen geringeren Orientierungsgrad. Die Erzielung von Hochleistungseigenschaften an naßgesponnenen Fäden erfordert daher ein neues Koagulationskonzept, das sowohl polymer-als auch prozeßimmanente Faktoren einschließt.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0878
    Keywords: Somatostatin-like activity ; Retina ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A somatostatin-like substance is demonstrated by light microscopic immunohistochemistry (PAP-method) in perikarya and cell processes of the retina of adult and infant rats. These perikarya are identified according to their size, arrangement and distribution. Each of the first two neuronal orders (receptors, bipolar cells, ganglionic cells) of the visual pathway can be associated with retinal cells reacting positively with anti-somatostatin. In the adult rat, perikarya and processes of (i) horizontal cells, (ii) amacrine cells and (iii) large neurons in the ganglionic layer are specifically labeled. The staining of middle-sized and small ganglion cells is probably caused by the close attachment of labeled fibers to non-reacting cells. Postnatally, the immunoreactive elements develop in parallel to the differentiation of the corresponding retinal layers. It is discussed whether the three types of retinal cells containing a somatostatin-like substance provide an inhibitory system to each of the two orders of retinal neurons.
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  • 8
    ISSN: 1432-0878
    Keywords: Somatostatin ; Cortical cells and fibers ; Immunohistochemistry ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Using light microscopic immunohistochemistry, somatostatinpositive structures were observed in the cortex of the rat. These structures, including cells and fibers, are widely distributed in all cortical laminae and are also found in the basal ganglia. The positive results were obtained exclusively in two groups of animals sacrificed during two different months of two subsequent years. The reason for this variability in the immunocytochemical stainability of cortical structures remains enigmatic.
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  • 9
    ISSN: 1432-0878
    Keywords: Luliberin (LRF)-terminals ; Somatostatin-terminals ; Subfornical organ ; Neurohemal regions ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary With the aid of light- and electron- microscopic immunocytochemistry, somatostatin- and luliberin (LRF)-positive fibers can be demonstrated in the rat subfornical organ (SFO). Each of the neurohormones has a specific location: LRF in the lateral parts of the organ, and somatostatin in the center of the posterior zone. Common to both neurohormone-containing fibers is the pattern in which they reach the organ as well as the fact that their terminals are located in the perivascular spaces of fenestrated vessels, i.e., within the limited neurohemal regions of the organ. Since injection of India ink of different colors demonstrates that the capillary bed of the SFO is connected with the central capillaries of the choroid plexus, the question arises as to whether the neurohormones released in the area of the SFO influence the choroid plexus.
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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