Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • S-100 protein  (2)
  • ADENOVIRUS  (1)
  • Dysgnathiechirurgie
  • biventricular pacing
  • 1
    Keywords: PEPTIDE ; CELLS ; EXPRESSION ; CELL ; Germany ; human ; IN-VIVO ; THERAPY ; VIVO ; SAMPLE ; SAMPLES ; INFECTION ; SERA ; DOMAIN ; BINDING ; LIMITATION ; antibodies ; antibody ; NEUTRALIZING ANTIBODIES ; virus ; IDENTIFICATION ; VECTORS ; VECTOR ; EFFICIENT ; TRAFFICKING ; REGION ; REGIONS ; SURFACE ; EPITOPE ; EPITOPES ; PREVALENCE ; adeno-associated virus ; TYPE-2 ; ADENOVIRUS ; AAV ; AAV2 VECTORS ; AFFINITY ; CANINE PARVOVIRUS ; DOMAINS ; EMPTY CAPSIDS ; NEUTRALIZATION ; immunogenic epitopes ; AAV antibodies ; human serum sampl
    Abstract: The high prevalence of human serum antibodies against adeno-associated virus type 2 (AAV) vectors represents a potential limitation for in vivo applications. Consequently, the development of AAV vectors able to escape antibody binding and neutralization is of importance. To identify capsid domains which contain major immunogenic epitopes, six AAV capsid mutants carrying peptide insertions in surface exposed loop regions (I-261, I-381, I-447, I-534, I-573, I-587) were analyzed. Two of these mutants, I-534 and I-573, showed an up to 70% reduced affinity for AAV antibodies as compared to wild-type AAV in the majority of serum samples. In addition, AAV mutant I-587 but not wild-type AAV efficiently transduced cells despite the presence of neutralizing antisera. Taken together, the results show that major neutralizing effects of human AAV antisera might be overcome by the use of AAV capsid mutants
    Type of Publication: Journal article published
    PubMed ID: 14625569
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1572-8595
    Keywords: biatrial pacing ; biventricular pacing ; pacemaker indication ; coronary sinus electrodes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The artificial activation of the heart modifies the mechanics of contraction and relaxation. While only little basic research has been addressed to this question, clinical observations showed that for hypertrophic as well as dilated cardiomyopathies appropriate pacing techniques can be useful. Pacing can influence the activation sequence. The spread out from a single site is slow, and so hypercontractility deminshed. With the use of multiple electrodes, two atrial and/or two ventricular, conduction delays in the atria or ventricles can be eliminated. Synchronisation of the cardiac activation has an anti-arrhythmic and positiv inotropic effect. This may lead to new indications for pacemakers or better to be named cardiac synchronisers.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-0878
    Keywords: S-100 protein ; Folliculo-stellate cells ; Normal human pituitary, anterior lobe ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary With the use of an anti-human S-100 protein antibody, it was possible to reveal a characteristic cell type in the anterior lobe of the normal human pituitary. These cells, so-called folliculo-stellate cells, were present in all pituitaries studied but their number varied from one gland to another. Immunoreactive cells, isolated or grouped, were arranged close to various secretory granulated cells. Especially by use of double immunoenzymatic labeling, it was evident that these cells are spatially related either to somatotropes, prolactin cells and “corticotropes”, or to glycoprotein-containing cells. Such immunoreactive cells were rare or absent in pseudo-follicular arrangements of secretory granulated cells. Since it is now possible to identify this cell type by light microscopy and since no reliable functional significance is known, it seems more advisable to term this cell type “stellate cell” instead of “folliculostellate cell”.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1432-0878
    Keywords: Islets of Langerhans ; S-100 protein ; Insulin ; Glucagon ; Somatostatin ; Pancreatic polypeptide ; Neuro-insular complex ; Monkey, Macaca irus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary S-100 protein-immunoreactive cells were demonstrated by immunocytochemical procedures in the pancreatic islets of Langerhans in the monkey Macaca irus. By use of antibodies against human S-100 protein or bovine S-100 protein, these cells were observed in all islets in the head and tail portions of the pancreas. Immunostained cells were usually located in the center of the islets or sometimes found in a more widely distributed form, but they were never arranged in a regular concentric fashion. The number of immunoreactive cells varied from one islet to another but it was relatively limited making up only 0.75%–6.3% of all insular cells. With the use of the double-immunoenzymatic procedure for demonstration of the four main endocrine cell types (insulin-, glucagon-, somatostatin-and pancreatic polypeptide producing elements), it was possible to establish that S-100 protein-immunoreactive cells represent a distinct cell type. Antibodies against S-100 protein-stained neuroinsular complexes. The present findings speak in favor of a new cell type to be added to the large variety of S-100 protein-immunoreactive cells outside the central nervous system.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1434-3940
    Keywords: Schlüsselwörter ; Dysgnathiechirurgie ; Operationssimulation ; Weichgewebesimulation ; Computersimulation ; Keywords ; Orthognathic surgery ; Preoperative planning ; Soft tissue simulation ; Computer-aided simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Background In addition to standard X-rays, photographic documentation, cephalometric and model analysis, a computer-aided, three-dimensional (3D) simulation system has been developed in close cooperation with the Institute of Communications of the Friedrich-Alexander-Universität Erlangen-Nürnberg. With this simulation system a photorealistic prediction of the expected soft tissue changes can be made. Prerequisites are a 3D reconstruction of the facial skeleton and a 3D laser scan of the face. After data reduction, the two data sets can be matched. Cutting planes enable the transposition of bony segments. The laser scan of the facial surface is combined with the underlying bone via a five-layered soft tissue model to convert bone movements on the soft tissue cover realistically. Conclusion Further research is necessary to replace the virtual subcutaneous soft tissue model by correct, topographic tissue anatomy.
    Notes: Hintergrund Im Rahmen eines Sonderforschungsbereichs der Deutschen Forschungsgemeinschaft (SFB 603) wurde in Zusammenarbeit mit dem Lehrstuhl für Nachrichtentechnik der Universität Erlangen-Nürnberg ein computergestütztes Simulationssystem zur dreidimensionalen, fotorealistischen Vorhersage von Weichgewebeveränderungen nach orthognathen Eingriffen entwickelt. Voraussetzung sind 3D-CT-Datensätze des Gesichtsschädels sowie eine ebenfalls dreidimensionale Laserabtastung der Gesichtsoberfläche. Beide Datensätze können nach Datenreduktion über ein mathematisches Verfahren so miteinander verknüpft werden, dass mit Hilfe so genannter “cutting planes” Verlagerungen von Knochensegmenten auf das bedeckende Weichgewebe realitätsnah übertragen werden können. Schlussfolgerung Es bedarf weiterer Forschungsanstrengungen, um auch die subkutanen Weichgewebelagen so in das Simulationsmodell zu integrieren, dass noch bestehende Abweichungen korrigiert werden können.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...