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  • UNITED-STATES  (16)
  • USA  (9)
  • 1
    Keywords: CANCER ; SURVIVAL ; Germany ; SYSTEM ; POPULATION ; SITES ; PATIENT ; IMPACT ; prognosis ; BREAST ; HEALTH ; COLORECTAL-CANCER ; leukemia ; DATABASE ; LONG-TERM SURVIVAL ; UNITED-STATES ; GASTRIC-CANCER ; TRENDS ; REGISTRY ; cancer registries ; PATIENT SURVIVAL ; PERIOD ANALYSIS ; CANCERS ; EMPIRICAL-EVALUATION ; cancer survival ; UP-TO-DATE ; therapeutic ; Filipino-Americans ; Philippines ; developing countries
    Abstract: Despite the availability of population-based cancer survival data from the developed and developing countries, comparisons remain very few. Such comparisons are important to assess the magnitude of survival discrepancies and to disentangle the impact of ethnic background and health care access on cancer survival. Using the SEER 13 database and databases from the Manila and Rizal Cancer Registries in the Philippines, a 5-year relative survival for 9 common cancers in 1998-2002 of Filipino-American cancer patients were compared with both cancer patients from the Philippines, having the same ethnicity, and Caucasians in the United States, being exposed to a similar societal environment and the same health care system. Survival estimates were much higher for the Filipino-Americans than the Philippine resident population, with particularly large differences (more than 20-30% units) for cancers with good prognosis if diagnosed and treated early (colorectal, breast and cervix), or those with expensive treatment regimens (leukaemias). Filipino-Americans and Caucasians showed very similar survival for all cancer sites except stomach cancer (30.7 vs 23.2%) and leukaemias (37.8 vs 48.4%). The very large differences in the survival estimates of Filipino-Americans and the Philippine resident population highlight the importance of the access to and utilisation of diagnostic and therapeutic facilities in developing countries. Survival differences in stomach cancer and leukaemia between Filipino-Americans and Caucasians in the United States most likely reflect biological factors rather than the differences in access to health care
    Type of Publication: Journal article published
    PubMed ID: 19240723
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  • 2
    Keywords: CANCER ; SURVIVAL ; Germany ; THERAPY ; SUPPORT ; EPIDEMIOLOGY ; LONG-TERM ; PATIENT ; prognosis ; MALIGNANCIES ; AGE ; leukemia ; LONG-TERM SURVIVAL ; UNITED-STATES ; TRENDS ; MALIGNANCY ; THERAPIES ; PERIOD ANALYSIS ; RELATIVE SURVIVAL ; development ; leukaemia ; CML ; cancer research ; DIVISION ; United States ; STATE ; chronic myelocytic leukemia
    Abstract: Within the past 10-15 years, major advances in therapy have strongly improved prognosis of patients with chronic myelocytic leukaemia (CML). We estimated trends in 5- and 10-year relative survival of patients developing CML after a previous malignancy in the United States from 1990-1994 to 2000-2004. Period analysis was employed to disclose recent developments with minimum delay. Overall, 5- and 10-year relative survival increased from 17.6% to 37.7% (p〈0.0001) and from 7.6% to 23.8% (p〈0.0001), respectively. Improvements were particularly strong in younger age groups. Prognosis of CML patients with previous malignancy no longer lags behind prognosis of patients with primary CML.
    Type of Publication: Journal article published
    PubMed ID: 19272642
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  • 3
    Keywords: POPULATION ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; LONG-TERM SURVIVAL ; UNITED-STATES ; PERIOD ANALYSIS ; ACUTE MYELOID-LEUKEMIA ; ACUTE MYELOBLASTIC-LEUKEMIA ; UP-TO-DATE ; ethnicity ; CANCER REGISTRY DATA
    Abstract: The survival of younger patients with acute leukemia has improved in the early 21st century, but it is unknown whether people of all ethnic and racial backgrounds have benefited equally. Using cancer registry data from the Surveillance, Epidemiology and End Results Program, we assessed trends in 5-year relative survival for patients aged 15 years or more with acute lymphoblastic leukemia and acute myeloblastic leukemia divided by racial and ethnic group, including non-Hispanic whites, African-Americans, Hispanics, and Asian-Pacific Islanders in the 1990s and the early 21st century. Modeled period analysis was used to obtain the most up-to-date estimates of survival. Overall, the 5-year survival increased from 31.6% in 1997-2002 to 39.0% in 2003-2008 for patients with acute lymphoblastic leukemia and from 15.5% in 1991-1996 to 22.5% in 2003-2008 for those with acute myeloblastic leukemia. Nevertheless, among patients with acute lymphoblastic leukemia, age-adjusted 5-year relative survival rates remained lower for African-Americans and Hispanics than for non-Hispanic whites. Among patients with acute myeloblastic leukemia, the increase in survival was greatest (from 32.6% in 1991-1996 to 47.1% in 2003-2008) for younger patients (15-54 years), and was more pronounced for non-Hispanic whites (+16.4% units) than for other patients (+10.8% units). Increases in survival are observed in all ethnic or racial groups. Nevertheless, among patients with acute leukemias, disparities in survival persist between non-Hispanic white people and people of other ethnic or racial groups. Disparities are increasing in younger patients with acute myeloblastic leukemia. Improvements in access to treatment, especially for minority patients, may improve outcomes.
    Type of Publication: Journal article published
    PubMed ID: 22929974
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  • 4
    Keywords: POPULATION ; LONG-TERM SURVIVAL ; UNITED-STATES ; PERIOD ANALYSIS ; RELATIVE SURVIVAL ; CELL TRANSPLANTATION ; cancer survival ; UP-TO-DATE ; HEALTH-INSURANCE ; RACE
    Abstract: Survival for patients with multiple myeloma has increased during the first decade of the 21st century. However, it is unknown whether the improvements in survival have extended equally in all ethnic groups. Using data from the United States Surveillance, Epidemiology and End Results Program, we assessed trends in survival and disease-related mortality for patients with myeloma by ethnic group, including non-Hispanic whites (nHw), AfricanAmericans (AA), Hispanics and people of Asian and Pacific Islander descent (API) from 1998-2001 to 2006-2009. Overall, age adjusted 5-year relative survival increased, from 35.6% in 1998-2001 to 44% in 2006-2009. The greatest improvements were observed for patients aged 15-49, for whom survival increased by + 16.8% units for nHw and + 14.4% units for AA, whereas improvement was less pronounced and not statistically significant in Hispanics and API. Excess mortality hazard ratios were 1.20 (95% confidence interval [CI]: 1.09-1.33) for AA and 1.25 (95% CI: 1.11-1.41) for Hispanics compared to nHw in 2006-2009. Although survival increased greatly for nHw with myeloma between 1998-2001 and 2006-2009, smaller increases were observed for people of other ethnic groups. Persistent excess mortality was seen for AA and Hispanic patients with myeloma. Ethnic inequalities persisted or even increased from earlier periods to 2006-2009. The results suggest that ethnic minorities may not have benefited from newer treatments to the same extent as nHw patients have.
    Type of Publication: Journal article published
    PubMed ID: 23879201
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  • 5
    Keywords: CANCER ; SURVIVAL ; tumor ; Germany ; human ; THERAPY ; DISEASE ; EPIDEMIOLOGY ; POPULATION ; PATIENT ; prognosis ; LYMPHOMA ; NUMBER ; AGE ; SURVEILLANCE ; UNITED-STATES ; OUTCOMES ; TRENDS ; STATES ; ADULT ; ADULTS ; RE ; THERAPIES ; ELDERLY-PATIENTS ; PERIOD ANALYSIS ; rituximab ; non-Hodgkin lymphoma ; LEVEL ; analysis ; methods ; technique ; USA ; EMPIRICAL-EVALUATION ; MEDICINE ; UP-TO-DATE ; LOW-GRADE ; non Hodgkin lymphoma ; neoplasm ; ARCH ; ACTIVE ANTIRETROVIRAL THERAPY ; CHOP CHEMOTHERAPY
    Abstract: Background: Non-Hodgkin lymphoma (NHL) is the most common hematologic malignant neoplasm in adults. We use the novel technique of period analysis to disclose the most recent trends in survival among adults diagnosed as having NHL on the population level with minimum delay. Methods: We estimated trends in 5-and 10-year relative survival in patients 15 years or older diagnosed as having NHL in the United States between 1990 and 2004 using data from the Surveillance, Epidemiology, and End Results (SEER) program. We also estimated survival by age, location and histologic type of the tumor, sex, and race to further elucidate trends in survival in this disease. Results: Overall, 5-year relative survival increased from 50.4% to 66.8%, and 10-year relative survival increased from 39.4% to 56.3% between 1990-1992 and 2002-2004. Improvements were most pronounced in patients younger than 45 years (+ 26.8 and + 27.1 percentage points for 5- and 10-year survival, respectively), but improvements were seen in all age groups, in both sexes, in both nodal and extranodal disease, and in both lowgrade and high-grade disease. Improvements in prognosis were less in black patients than in white patients, especially in younger black patients. Conclusions: Our period analysis discloses a strongly improved outlook for patients diagnosed as having NHL in recent years. Changes in treatment of the disease and a decrease in the number of human immunodeficiency virus-related NHL cases attributable to highly active antiretroviral therapy are probably primarily responsible for these improvements
    Type of Publication: Journal article published
    PubMed ID: 18332290
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  • 6
    Keywords: CANCER ; SURVIVAL ; Germany ; DIAGNOSIS ; EPIDEMIOLOGY ; TIME ; PATIENT ; LYMPHOMA ; MALIGNANCIES ; AGE ; RATES ; leukemia ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; DATABASE ; LONG-TERM SURVIVAL ; SURVEILLANCE ; US ; UNITED-STATES ; REVEALS ; CHILDREN ; TRENDS ; HODGKINS-DISEASE ; HEMATOLOGIC MALIGNANCIES ; STATES ; MALIGNANCY ; ONCOLOGY ; CHILDHOOD ; RE ; aging ; INCREASE ; PERIOD ANALYSIS ; ACUTE MYELOID-LEUKEMIA ; non-Hodgkin lymphoma ; analysis ; methods ; USA ; population-based ; IMPROVEMENT ; INCREASES ; UP-TO-DATE ; modeling ; ADOLESCENTS 1978-1997 ; INFORMATION-SYSTEM PROJECT ; non Hodgkin lymphoma ; non-Hodgkin ; TO-DATE ; STATE ; COLLABORATIVE BRITISH COHORT ; CANCER-PATIENT SURVIVAL
    Abstract: Background Advances in the treatment of childhood hematologic malignancies have led to improvements in survival for several of these conditions during the past few decades, but most population-based survival data available to date refer only to patients diagnosed up to the mid-1990s. Methods We used period analysis to assess trends in 5- and 10-year survival in US patients younger than 15 years of age at diagnosis with four hematologic malignancies-acute lymphoblastic leukemia, acute non-lymphoblastic leukemia, Hodgkin lymphoma, and non-Hodgkin lymphoma-over three recent 5-year intervals, 1990-1994, 1995-1999, and 2000-2004, using data on a total of 6957 patients from the Surveillance, Epidemiology, and End Results database. Expected survival for 2005-2009 was estimated by modeling from trends in the preceding intervals. Results Major improvements in 5- and 10-year relative survival between 1990-1994 and 2000-2004 were seen for acute lymphoblastic leukemia (from 80.2% to 87.5% and from 73.4% to 83.8%, respectively), acute non-lymphoblastic leukemia (from 41.9% to 59.9% and from 38.7% to 59.1%, respectively), and non-Hodgkin lymphoma (from 76.6% to 87.7% and from 73.0% to 86.9%, respectively). For those diagnosed with Hodgkin lymphoma, 5- and 10-year survival rates for the 1990-1994 period were 96.1% and 94.4%, respectively, and these rates did not change substantially in the later time periods. Projected 10-year survival rates for children diagnosed in the 2005-2009 period were 88.0% for acute lymphoblastic leukemia, 63.9% for acute non-lymphoblastic leukemia, 90.6% for non-Hodgkin lymphoma, and 94.3% for Hodgkin lymphoma. Conclusions Application of period analysis to a population-based study of childhood hematologic malignancies reveals ongoing increases in survival for three of the four common childhood hematologic malignancies
    Type of Publication: Journal article published
    PubMed ID: 18780868
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  • 7
    Keywords: SURVIVAL ; Germany ; COHORT ; EPIDEMIOLOGY ; PATIENT ; PERFORMANCE ; PATTERNS ; DATABASE ; LONG-TERM SURVIVAL ; UNITED-STATES ; TRENDS ; EUROPE ; MULTIPLE-MYELOMA ; multiple myeloma ; cancer registries ; PERIOD ANALYSIS ; thalidomide ; EMPIRICAL-EVALUATION ; cancer survival ; UP-TO-DATE ; OLDER
    Abstract: New therapeutic options have led to substantial increases in survival expectations of younger patients with multiple myeloma in recent years. In the past, the impact of these innovations on long-term survival has been disclosed only with substantial delay. We aimed to derive up-to-date estimates of long-term survival expectations of concurrently diagnosed multiple myeloma patients. Using data from the 1973-2005 database of the Surveillance, Epidemiology, and End Results (SEER) Program, we employed a novel model-based projection method to project 5-and 10-year relative survival expectations of multiple myeloma patients in the United States diagnosed in 2006-2010. Preliminary empirical evaluation of the method using historical data indicated good performance. Projected 5-year relative survival for patients diagnosed in 2006-2010 below 45 years of age is 68.0%, which exceeds the most up-to-date estimates obtained from traditional cohort and period analysis by 15.5 and 7.0 percent units respectively. Ten-year relative survival projection for patients in this age group is 55.3%, exceeding the most up-to-date estimates from traditional cohort and period analysis by 19.7 and 7.4 percent units respectively. By contrast, survival projections remain much lower and hardly exceed estimates from traditional survival analysis for older patients. Patients diagnosed with multiple myeloma in 2006-2010, especially those diagnosed at younger ages, are expected to have much higher long-term survival perspectives than suggested by previously available survival statistics
    Type of Publication: Journal article published
    PubMed ID: 19144659
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  • 8
    Keywords: CANCER ; SURVIVAL ; evaluation ; Germany ; THERAPY ; COHORT ; DISEASE ; EPIDEMIOLOGY ; LONG-TERM ; POPULATION ; PATIENT ; prognosis ; PERFORMANCE ; LYMPHOMA ; AGE ; statistics ; chemotherapy ; DATABASE ; LONG-TERM SURVIVAL ; EUROPE ; Hodgkin's lymphoma ; REGISTRY ; THERAPIES ; cancer registries ; PERIOD ANALYSIS ; RELATIVE SURVIVAL ; LEVEL ; USA ; population-based ; EMPIRICAL-EVALUATION ; PROGRESS ; cancer survival ; ERROR ; SPREAD ; ABVD
    Abstract: Available long-term survival figures for patients with Hodgkin's lymphoma (HL) from population-based cancer registries mostly refer to patients diagnosed in the 1980s and 1990s, and do not reflect recent progress in and spread of effective therapy at the population level. Using data from the Surveillance, Epidemiology, and End Results program, we employed a novel model-based projection method to estimate 5- and 10-year relative survival expectations of HL patients in the U. S. diagnosed in 2006-2010. Preliminary empirical evaluation of the method using historical data indicates excellent performance. Projections of 10-year relative survival percentages and their standard errors by age groups are as follows: 15-24 y: 94.7 (1.1), 25-34 years, 89.4 (1.5); 35-44 years, 90.1 (1.6); 45-54 years, 83.6 (2.7); 55-64 years, 70.5 (4.7); 65-74 years, 48.5 (5.9); and 75+ years, 24.0 (5.7). These estimates are 2.5-11.1 percentage points higher than those obtained by standard cohort analysis from the same database ( pertaining to patients diagnosed in 1991-1995). Patients diagnosed with HL in 2006-2010 have higher long-term survival expectations than suggested by conventional survival statistics from population-based cancer registries. The 10-year survival expectations are now close to or exceed 90% in all age groups up to age 45, and exceed 80% and 70% in the 45-54 and 55-64 age groups, respectively. The Oncologist 2009; 14: 806-813
    Type of Publication: Journal article published
    PubMed ID: 19648314
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  • 9
    Keywords: CANCER ; SURVIVAL ; Germany ; DISEASE ; EPIDEMIOLOGY ; RISK ; PATIENT ; prognosis ; LYMPHOMA ; chemotherapy ; DATABASE ; UNITED-STATES ; TRENDS ; B-CELL LYMPHOMA ; PERIOD ANALYSIS ; development ; non-Hodgkin lymphoma ; EMPIRICAL-EVALUATION ; UP-TO-DATE ; ACTIVE ANTIRETROVIRAL THERAPY ; PLUS RITUXIMAB ; prior malignancy
    Abstract: An increased risk of non-Hodgkin lymphoma (NHL) has been observed in the survivors of several malignancies. Survival for patients with primary NHL has improved in the 1990s and early 21st century, but population-based survival data for patients diagnosed with NHL after a prior malignancy are lacking. We estimated trends in age-specific 5- and 10-year relative survival of NHL patients with prior malignancy in the United States from 1990-1994 to 2000-2004 using the Surveillance, Epidemiology and End Results Program database. Period analysis of survival was employed to disclose recent developments with minimum delay. Five- and 10-year relative survival has strongly improved for NHL patients with prior malignancy between 1990-1994 and 2000-2004, from 38.0 to 54.1% and 24.4 to 41.0%, respectively. Despite a strong increase in relative survival over time, patients with prior malignancies continued to have a worse prognosis compared with those with no prior malignancy
    Type of Publication: Journal article published
    PubMed ID: 19197735
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  • 10
    Keywords: CANCER ; SURVIVAL ; Germany ; DIAGNOSIS ; DISEASE ; EPIDEMIOLOGY ; PATIENT ; EXPERIENCE ; WOMEN ; CLINICAL-TRIALS ; MEN ; DATABASE ; UNITED-STATES ; ADULTS ; PERIOD ANALYSIS ; EMPIRICAL-EVALUATION ; UP-TO-DATE ; OLDER
    Abstract: Acute lymphoblastic leukemia ( ALL) is an uncommon but highly fatal disease in adults. We used period analysis to data from the Surveillance, Epidemiology, and End Results ( SEER) database to disclose changes in outcomes for patients diagnosed with ALL in the United States in the 2 decades between 1980-1984 and 2000-2004. Major improvement in survival was observed for patients less than 60 years of age. Improvement in survival was greater for women than for men, but was significant for both genders. The greatest improvement was seen in patients aged 15 to 19, in whom 5-year relative survival improved from 41.0% to 61.1%, and 10-year survival improved from 33.0% to 60.4%. Lesser but significant improvements were seen for age groups 20-29, 30-44, and 45-59. Survival for patients aged 60 and over remained essentially unchanged at levels around or below 10%, respectively. Survival has improved for patients with ALL over the time period studied, but treatment of older patients remains a difficult issue. ( Blood. 2009; 113: 1408-1411)
    Type of Publication: Journal article published
    PubMed ID: 18974371
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