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  • VOLUME  (2)
  • 1
    Keywords: IRRADIATION ; radiotherapy ; SURVIVAL ; tumor ; carcinoma ; CELL ; Germany ; THERAPY ; TOXICITY ; CLASSIFICATION ; DIAGNOSIS ; VOLUME ; TUMORS ; radiation ; PATIENT ; COMPLEX ; COMPLEXES ; treatment ; TARGET ; PROGRESSION ; TUMOR PROGRESSION ; RATES ; MELANOMA ; CARCINOMAS ; adenocarcinoma ; squamous cell carcinoma ; IMRT ; INITIATION ; CELL CARCINOMA ; ONCOLOGY ; methods ; EVALUATE ; survival rate ; SQUAMOUS-CELL ; paranasal sinuses ; TUMOR-CONTROL
    Abstract: ABSTRACT: INTRODUCTION: The aim of the study was to evaluate the clinical outcome of intensity modulated radiotherapy (IMRT) in 46 patients with paranasal sinus tumors with special respect to treatment-related toxicity. PATIENTS AND METHODS: We treated 46 patients with histologically proven tumors of the paranasal sinuses with IMRT. Histological classification included squamous cell carcinoma in 6, adenocarcinoma in 8, adenoidcystic carcinoma in 20 and melanoma in 8 patients, respectively.Six patients had been treated with RT during initial therapy after primary diagnosis, and IMRT was performed for the treatment of tumor progression as re-irradiation. RESULTS: Overall survival rates were 96% at 1 year, 90% at 3 years.Calculated from the initiation of IMRT as primary radiotherapy, survival rates at 1 and 3 years were 95% and 80%.In six patients IMRT was performed as re-irradiation, and survival rate calculated from re-irradiation was 63% at 1 year.Local control rates were 85% at 1, 81% at 2 and 49% at 3 years after primary RT and 50% at 1 year after re-irradiation.Distant metastases-free survival in patients treated with IMRT as primary RT was 83% after 1 and 64% after 3 years. For patients treated as primary irradiation with IMRT, the distant control rate was 83% at 1 year and 0% at 2 years.No severe radiation-induced side-effects could be observed. CONCLUSION: IMRT for tumors of the paranasal sinuses is associated with very good tumor control rates. Treatment-related acute and long-term toxicity can be minimized as compared to historical results with conventional RT
    Type of Publication: Journal article published
    PubMed ID: 16859556
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  • 2
    Keywords: OPTIMIZATION ; CANCER ; radiotherapy ; tumor ; carcinoma ; THERAPY ; SYSTEM ; VOLUME ; RISK ; TISSUE ; PATIENT ; primary ; REDUCTION ; TISSUES ; FIELD ; PROTON ; TARGET ; EXPERIENCE ; RADIATION-THERAPY ; chemotherapy ; SWEDEN ; HEAD ; INTENSITY-MODULATED RADIOTHERAPY ; NORMAL TISSUE ; treatment planning ; NECK TUMORS ; IMRT ; proton therapy ; THERAPIES ; QUALITY-OF-LIFE ; methods ; 3D ; technique ; ENGLAND ; PHOTON ; IMPT ; Protons ; FIELDS ; HEARING-LOSS
    Abstract: Background: The aim of this treatment planning study was to investigate the potential advantages of intensity-modulated (IM) proton therapy (IMPT) compared with IM photon therapy (IMRT) in nasopharyngeal carcinoma (NPC). Methods: Eight NPC patients were chosen. The dose prescriptions in cobalt Gray equivalent (GyE) for gross tumor volumes of the primary tumor (GTV-T), planning target volumes of GTV-T and metastatic (PTV-TN) and elective (PTV-N) lymph node stations were 72.6 Gy(E), 66 Gy(E), and 52.8 Gy(E), respectively. For each patient, nine coplanar fields IMRT with step-and-shoot technique and 3D spot-scanned three coplanar fields IMPT plans were prepared. Both modalities were planned in 33 fractions to be delivered with a simultaneous integrated boost technique. All plans were prepared and optimized by using the research version of the inverse treatment planning system KonRad (DKFZ, Heidelberg). Results: Both treatment techniques were equal in terms of averaged mean dose to target volumes. IMPT plans significantly improved the tumor coverage and conformation (P 〈 0.05) and they reduced the averaged mean dose to several organs at risk (OARs) by a factor of 2-3. The low-to-medium dose volumes (0.33-13.2 Gy(E)) were more than doubled by IMRT plans. Conclusion: In radiotherapy of NPC patients, three-field IMPT has greater potential than nine-field IMRT with respect to tumor coverage and reduction of the integral dose to OARs and nonspecific normal tissues. The practicality of IMPT in NPC deserves further exploration when this technique becomes available on wider clinical scale
    Type of Publication: Journal article published
    PubMed ID: 18218078
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