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  • acylated anthocyanins  (2)
  • ATP  (1)
  • Angiotomography  (1)
  • COMPUTED-TOMOGRAPHY  (1)
  • 1
    Keywords: BLOOD ; Germany ; MODEL ; ALGORITHM ; CT ; SYSTEM ; SYSTEMS ; liver ; RISK ; TISSUE ; computed tomography ; SURGERY ; LIVER-TRANSPLANTATION ; TRANSPLANTATION ; RESECTION ; tomography ; COMPUTED-TOMOGRAPHY ; ADULT ; PREOPERATIVE EVALUATION ; SCIENCE ; FULMINANT HEPATIC-FAILURE ; SCAN ; TIMES ; GRAFT VOLUME ; hepatic blood pool ; liver volumetry ; living donor liver transplantation ; LIVING DONORS ; RIGHT LOBE ; SPLEEN VOLUME ; vessel tree
    Abstract: Exact preoperative determination of the liver volume is of great importance prior to hepatobiliary surgery, especially in living donated liver transplantation (LDLT) and extended hepatic resections. Modern surgery-planning systems estimate these volumes from segmented image data. In an experimental porcine study, our aim was (1) to analyze and compare three volume measurement algorithms to predict total liver volume, and (2) to determine vessel tree volumes equivalent to nonmetabolic liver tissue. Twelve porcine livers were examined using a standardized three-phase computed tomography (CT) scan and liver volume was calculated computer-assisted with the three different algorithms. After hepatectomy, livers were weighed and their vascular system plasticized followed by CT scan, CT reconstruction and re-evaluation of total liver and vessel volumes with the three different algorithms. Blood volume determined by the plasticized model was at least 1.89 times higher than calculated by multislice CT scans (9.7% versus 21.36%, P = 0.028). Analysis of 3D-CT-volumetry showed good correlation between the actual and the calculated liver volume in all tested algorithms with a high significant difference in estimating the liver volume between Heymsfield versus Heidelberg (P = 0.0005) and literature versus Heidelberg (P = 0.0060). The Heidelberg algorithm reduced the measuring error with deviations of only 1.2%. The present results suggest a safe and highly predictable use of 3D-volumetry in liver surgery for evaluating liver volumes. With a precise algorithm, the volume of remaining liver or single segments can be evaluated exactly and potential operative risks can therefore be better calculated. To our knowledge, this study implies for the first time a blood pool, which corresponds to nonmetabolic liver tissue, of more than 20% of the whole liver volume. (C) 2010 Elsevier Inc. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 19765736
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  • 2
    ISSN: 1420-9071
    Keywords: Liver ischemia ; hepatic function ; aminopyrine demethylation ; ATP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Hepatic function was assessed by the aminopyrine breath test (ABT) in male Sprague Dawley rats 24 h after partial hepatic ischemia. ABT decreased progressively to 26.3 (p〈0.05) and 19.7% of dose (p〈0.05) after 90 and 120 min of ischemia, respectively. ABT at 24 h after injury was correlated to the concentration of ATP in the ischemic lobes 1 h after the onset of reperfusion (r2=0.971) but not to ALT activity in plasma at 1 h (r2=0.391). We conclude that postischemic ATP levels are a better index of subsequent hepatic function than ALT.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-5044
    Keywords: acylated anthocyanins ; cinnamic acids ; daucus carota (wild carrot) ; flavonoid intermediates ; HPLC separations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Anthocyanins isolated and characterized from the wild carrot suspension cultures used here were 3-O-β-D-glucopyranosyl-(1→6)-[β-D-xylopyranosyl-(1→2)-]β-D〈-galactopyranosylcyanidin (1), 3-O-[β-D- xylopyranosyl-(1→2)-β-D-galactopyranosyl]cyanidin (2), 3-O-(6-O-sinapoyl)-β-D-glucopyranosyl-(1→6)-[β-D- xylopyranosyl-(1→2)-]β-D-galactopyranos ylcyanidin (3), 3-O-(6-O-feruoyl)-β-D-glucopyranosyl-(1→6)-[β- D-xylopyranosyl-(1→2)-]β-D-galactopyranosylcyanidin (4), 3-O-(6-O-coumaroyl)-β-D-glucopyranosyl-(1→6)- [β-D-xylopyranosyl-(1→2)-]β-D-galactopyrano sylcyanidin (5), 3-O-[6-O-(3,4,5-trimethoxycinnamoyl)]-β- D-glucopyranosyl-(1→6)-[β-D-xylopyranosyl-(1→2)-]β-D-galactopyranosylcyanidin (6), 3-O-[6-O-(3,4-dime- thoxycinnamoyl)]-β-D-glucopyranosyl-(1→6)-[β-D-xylopyranosyl-(1→2)-]β-D-galactopyranosylcyanidin (7), 3-O-[(6-O-sinapoyl)-β-D-glucopyranosyl-(1→6)-β-D-galactopyranosyl]cyanidin (8), and 3-O-(β-D-galactopyranosyl)cyanidin (9). Except when cinnamic acids were provided in the culture medium, the major anthocyanin present in the two clones examined was 2. When the naturally occurring and some non-naturally occurring cinnamic acids were provided individually in the medium, 1 and 2 were minor components and the anthocyanin acylated with the supplied cinnamic acid, namely 3, 4, 5, 6, or 7 was the major anthocyanin present in the tissue. When caffeic acid was provided the major anthocyanin in the tissue was 4, thereby suggesting that the caffeic acid was methylated before its use in anthocyanin biosynthesis. Other cinnamic acids supplied had limited effects on the anthocyanins accumulated and appeared not to result in the accumulation of new anthocyanins by the tissue. Thus the tissue can use some but not all analogues of sinapic acid to acylate anthocyanins. Additional anthocyanins were detected in extracts of the wild carrot tissue cultures using mass spectrometry (both MS/MS and HPLC/MS). The additional compounds detected have also been found in cultures of black carrot, an Afghan cultivar of Daucus carota ssp. sativa and the flowers of wild carrot giving no evidence for qualitative differences in the anthocyanins synthesized by subspecies, cell cultures from subspecies, or clones from cell cultures. There are major differences in the amounts of individual anthocyanins found in cultures from different subspecies and in different clones from cell cultures. Here anthocyanins without acyl groups were usually found in the tissues and their accumulation is discussed. On the basis of the structures of the isolated anthocyanins, a likely pathway from cyanidin to the accumulated anthocyanins is proposed and discussed.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1920
    Keywords: Pituitary adenomas ; Angiotomography ; Empty sella ; Carotid angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The supra sellar extension of even small sized pituitary adenomas can be delineated with accuracy by angiotomography. This technique avoids the discomfort of pneumoencephalography in many patients. Angiotomography is also useful for the differential diagnosis of empty sellae.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Phytochemistry 31 (1992), S. 1593-1601 
    ISSN: 0031-9422
    Keywords: 4-coumaroyl, feruloyl, 4-hydroxybenzoyl and sinapoyl derivatives ; Apiaceae ; Daucus carota ; acylated anthocyanins ; carrot cell suspension cultures ; cyanidin 3-(2''-xylosyl-6''-glucosylgalactoside) ; cyanidin 3-lathyroside ; intramolecular copigmentation.
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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