Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract The ability to stabilize dopamine hydrochloride formulations via the utilization of a secondary bag containing an antioxidant has been established. By physically separating the drug formulation from the stabilization solution, the chemistry of both solutions can be optimized independently so as to ensure product efficacy. Factors controlling the effectiveness of the proposed stabilization strategy are discussed in the context of actual experimental results. Such a strategy is effective in terms of protecting the formulation during processing/storage only if the product is stored in an oxygen barrier overpouch.
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