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  • Key words Home teleradiology – Resident supervision – Subspecialist teleconsultations  (1)
  • breast cancer  (1)
  • 2000-2004  (2)
  • 1960-1964
  • 1
    ISSN: 1573-7217
    Keywords: breast cancer ; catalase ; glutathione peroxidase ; malondialdehyde ; reactive oxygen metabolites ; superoxide dismutase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Reactive oxygen metabolites (ROMs), including superoxide anion (O2 ·−), hydrogen peroxide (H2O2) and hydroxyl radical (·OH), play an important role in carcinogenesis. There are some primary antioxidants such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) which protect against cellular and molecular damage caused by the ROMs. We conducted the present study to determine the rate of O2 ·− and H2O2 production, and concentration of malondialdehyde (MDA), as an index of lipid peroxidation, along with the SOD, GPx and CAT activities in 54 breast cancer (BC) patients. Forty-two age- and sex-matched patients with minor surgical problems, who had no history of any neoplastic or breast disorders, were taken as controls. The rate of O2 ·− production was significantly higher (p〈0.001) in BC patients than controls, irrespective of clinical stages and menopausal status. Similarly, H2O2 production was significantly higher in BC patients, especially in stage III and postmenopausal groups, as compared to the respective controls. MDA concentration was also observed significantly elevated in stage II (p〈0.001), stage III (p〈0.01), postmenopausal (p〈0.005), and premenopausal (p〈0.02) group as compared to their corresponding controls. SOD and GPx activities were found significantly raised in all the groups (p〈0.001), except the GPx activity was found a smaller alteration in stage IV (p〈0.02). On the contrary, CAT activity was found significantly depressed in all the study groups. The maximum depression was observed in stage II (−61.8%). Lower CAT activity in our study may be the effect of higher production of ROMs, particularly O2 ·− and ·OH. SOD and GPx, however, were less effected by these higher ROMs production. The results of our study have shown a higher ROMs production and decreased CAT activity, which support the oxidative stress hypothesis in carcinogenesis. The relatively higher SOD and GPx may be due to the response of increased ROMs production in the blood. However, the higher SOD and GPx activities may be inadequate to detoxify high levels of H2O2 into H2O leading to the formation of the most dangerous ·OH radical followed by MDA. Therefore, administration of CAT may be helpful in the management of BC patients. However, further elaborate clinical studies are required to evaluate the role of such antioxidant enzymes in BC management.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1438-1435
    Keywords: Key words Home teleradiology – Resident supervision – Subspecialist teleconsultations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Study objective: To determine whether teleconsultations by first-year radiology residents with faculty thoracic radiologists, using diagnostic-quality teleradiology workstations in the radiologists' homes, would add clinical value for the acute management of intensive care unit patients after regular working hours. Design and setting: First-year radiology residents recorded key findings on new computed chest radiographs from 173 cardiothoracic intensive care unit patients. After consulting with home-based thoracic radiologists on the same images via teleradiology, they recorded any revisions to their original interpretations. An interdisciplinary evaluation panel determined whether the revisions of the residents' initial readings after the teleradiology consultations would have influenced the acute clinical care of these patients. Measurements and results: In 119 of the 173 cases (69 %), differences in key findings on the chest images were observed between the first-year residents' preliminary readings and their revised readings after teleconsultation with a thoracic radiologist. The evaluation panel determined that the changes in key findings after the teleconsultations could have influenced acute patient care in 86 of the 173 cases (50 %). Conclusions: Through rapid teleradiology consultations with residents, focusing on the key findings on newly-obtained computed chest images, home-based thoracic radiologists provided information of added clinical value for the acute management of cardiothoracic intensive care unit patients in one-half of the cases studied. Diagnostic workstations in the homes of faculty subspecialists may enable first-year radiology residents on night or weekend duty to obtain clinical supervision from faculty subspecialists that approximates more closely the level of supervision that they receive during regular working hours.
    Type of Medium: Electronic Resource
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