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  • Polymer and Materials Science  (2)
  • dopamine hydrochloride  (2)
  • PCB  (1)
  • c-erbA  (1)
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  • 1
    ISSN: 1573-904X
    Keywords: dopamine hydrochloride ; oxygen-sensitive drugs ; premixed products ; product stabilization ; antioxidants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The ability to stabilize dopamine hydrochloride formulations via the utilization of a secondary bag containing an antioxidant has been established. By physically separating the drug formulation from the stabilization solution, the chemistry of both solutions can be optimized independently so as to ensure product efficacy. Factors controlling the effectiveness of the proposed stabilization strategy are discussed in the context of actual experimental results. Such a strategy is effective in terms of protecting the formulation during processing/storage only if the product is stored in an oxygen barrier overpouch.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-904X
    Keywords: drug delivery ; ion exchange ; micromembrane ; dopamine hydrochloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The exchange of pharmaceutically significant amounts of dopamine across a micromembrane is reported, establishing the practical basis for such a drug delivery system. Drug release was accomplished with a commercially available device initially intended for use as a postcolumn reactor in ion chromatography. Release of other ionic drugs (e.g., methyldopate and piperacillin) was also achieved but with a lesser efficiency than was dopamine, presumably because of a size effect. The effect of releasing ion identification and concentration, the flow rate of the delivery solution and concentration of drug in the device reservoir on the drug release efficiency was examined. Under optimal conditions the efficiency approaches 80%, and 1 mg of drug is released/ml of delivery solution. Alternatively, operating conditions can be changed so that magnitude of release is optimized but absolute efficiency is sacrificed. Under such conditions the magnitude of dopamine release approaches 2 mg/ml but exchange efficiency is approximately 25%.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 44 (1992), S. 1223-1231 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The migration of several low molecular weight model solutes through a polypropylene/polyolefin blend was examined via a permeation-cell experimental design. Diffusion coefficients and permeation rates are obtained for the model solutes. The permeation rates exhibit Arrenhius-type behavior. A bimodal permeation model is proposed wherein the permeation rate is correlated with the linear combination of a solute's Permicor constant and solute/polymer equilibrium interaction constant. The model effectively predicts the behavior of the polymer and solutes studied. The implication of the observed behavior to container compatibility assessment is discussed.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The interaction between several polymeric materials, typical of those that have application as parenteral product containers, and 16 marker solutes was evaluated. Polymers used included polypropylene, polyvinyl chloride, ethylenevinyl acetate, an olefin rubber, a polyester ether block copolymer, and various composites of these materials. In addition, the partitioning of solutes between two common PVC plasticizers (dioctyl phthalate and butyryl hexyl citrate) and water was also examined. Correlation between equilibrium interaction constants (Eb) (which describe the equilibrium distribution of a solute between contacting polymer and solution phases) and solute octanol-water (Po-w) or hexane-water (Ph-w) partition coefficients were in general poor for all materials studied. However, a bivariate linear interaction model relating Eb to both partition coefficients: \documentclass{article}\pagestyle{empty}\begin{document}$$ \log E_b = a\left( {\log P_{{\rm o} - {\rm w}} } \right) + b\left( {\log P_{{\rm h} - {\rm w}} } \right) + c$$\end{document} effectively mimicked the interaction behavior of all materials evaluated. The utilization of the developed models to facilitate container compatability assessments is discussed. In addition, the use of a critical ratio of binding constants for a pair of solutes is introduced as a means of qualitatively assessing the effectiveness of a particular solvent as a polymer model.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    FEBS Letters 339 (1994), S. 185-188 
    ISSN: 0014-5793
    Keywords: PCB ; Protooncogene expression ; Tumor promoter ; c-erbA ; c-erbB ; c-raf
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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