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  • 71.70J  (1)
  • c-fos  (1)
  • Chitin biosynthesis
  • DSC
  • Springer  (2)
  • 1990-1994  (2)
  • Springer  (2)
  • 1
    ISSN: 1434-6079
    Keywords: 76.30F ; 76.30H ; 71.70J
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The possibilities to identify small diluted paramagnetic cluster defects in solids by Electron Paramagnetic Resonance are demonstrated in two examples: the Mn 4 0 cluster and a Cu-Au cluster in silicon crystals. A comprehensive picture of the clusters can be given containing the chemical nature of the constituents, the spatial arrangement, the charge states and the electronic structure.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-9368
    Keywords: growth factors ; SV40 T antigen ; hGH ; c-fos ; c-myc ; immortalized hepatocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A clonal hepatocyte line (FMH-202-2), derived from livers of fetal transgenic mice harbouring human growth hormone (hGH) and SV40 T antigen as transgenes, was used in the investigation of protooncogene expression involved in liver-specific growth control and/or in hepatocellular transformation. In this model system, representing an immortalized, yet untransformed phenotype, the transgenes hGH and SV40 T antigen were expressed constitutively. The c-fos protooncogene was induced by incubation with insulin, epidermal growth factor (EGF) and insulin-like growth factor (IGF-I) in a transient manner comparable to its expression in primary murine hepatocytes. Elucidation of second messenger mechanisms demonstrated that c-fos induction by hepatotrophic growth factors was not mediated by protein kinase C. In contrast to primary hepatocytes, the c-myc protooncogene exhibited a constitutive expression pattern which was independent of growth factor stimulation. These results indicate that apart from hGH and SV40 T antigen, c-myc may play a role in cellular immortalization, but that constitutive expression of these genes, even in combined coexpression, does not suffice to induce the transformed phenotype.
    Type of Medium: Electronic Resource
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