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  • 1
    ISSN: 1573-904X
    Keywords: iontophoresis ; capillary electrophoresis ; TRH ; formulation ; electroosmosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Capillary electrophoresis (CE) is an extremely efficient separations tool which can also be used to determine fundamental molecular parameters, e.g., the electrophoretic mobility of a molecule. We have studied the changes in the CE estimated electrophoretic mobility of thyrotropin releasing hormone (TRH) as a function of pH and ionic strength. Further, we have used CE to estimate the mobilities of two synthetic analogs of TRH to examine the behavior of positive (basic) and negative (acidic) peptides under the conditions of this work. These data were then compared with literature values of iontophoretic flux of these molecules under similar formulation conditions. Our results suggest that CE could potentially assist formulation optimization for the iontophoretic delivery of peptides.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Microcolumn Separations 1 (1989), S. 289-293 
    ISSN: 1040-7685
    Keywords: capillary electrophoresis ; polystyrene ; particles ; nanospheres ; surfactant ; separation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The analytical capillary electrophoretic separation of polystyrene nanospheres is reported. Although these particles are negatively charged and possess intrinsic mobilities, their Separations are based upon particle size with the smallest particles having the highest velocity through the capillary. Pretreatment of the capillary with a cationic surfactant is necessary to observe these Separations. Interestingly, particles larger than about 700 nm in diameter cannot be observed to move through a 50-μm- i.d. capillary, whereas particles as small as 39 nm in diameter can be resolved in this system. In contrast to normal electrophoretic Separations, the mechanism of this process appears to be that of particlexapillary wall interaction as mediated by the adsorbed surfactant.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1040-7685
    Keywords: electroosmosis ; buffer effects ; capillary electrophoresis ; alcohol effects ; ionic strength ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Solute migration in capillary electrophoresis is the sum of the molecularly specific electrophoretic mobility and the electric-field-induced solvent flow (electroosmosis). This solvent flow is an important component of capillary electrophoresis and has been linked to resolution and automation aspects of this technique. This work demonstrates that equivalent electroosmotic flows can be achieved using different buffer types if the ionic strength is equal in the two systems. The effects of the addition of acetonitrile and several different alcohols on electroosmotic flow are also examined. The data suggest a unique surface effect of alcohols on the observed electroosmotic flow.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1040-7685
    Keywords: particles ; mobility ; capillary electrophoresis ; adsorption ; polystyrene ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Capillary electrophoresis (CE) can be used to determine the electrophoretic mobilities of polystyrene particles from the migration times of these particles assuming that (1) the particles do not interact with the capillary wall, (2) the particles can be detected, and (3) the colloidal suspension of particles is physically stable over the time course of the CE experiment (i.e., 〉 5 min). CE offers advantages of small sample size, automation, and ease of analysis. CE determined mobility data are used to qualitatively assess the adsorption of polymeric surfactants onto polystyrene particles.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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