Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: CANCER ; Germany ; human ; neoplasms ; RISK ; TIME ; ASSOCIATION ; LYMPHOMA ; MALIGNANCIES ; WOMEN ; MEN ; leukemia ; cancer risk ; CARCINOGENS ; hair dyes ; case-control studies ; NON-HODGKINS-LYMPHOMA ; MALIGNANCY ; PRODUCTS ; HUMAN CANCER ; INCREASE ; INTERVAL ; odds ratio ; population-based ; CANCER-RISK ; lymphatic system
    Abstract: Hair dyes have been evaluated as possibly being mutagenic and carcinogenic in animals. Studies of the association between human cancer risk and use of hair dyes have yielded inconsistent results. The authors evaluated the risk of lymphoid malignancies associated with personal use of hair dyes. The analysis included 2,302 incident cases of lymphoid neoplasms and 2,417 hospital- or population-based controls from the Czech Republic, France, Germany, Ireland, Italy, and Spain (1998-2003). Use of hair dyes was reported by 74% of women and 7% of men. Lymphoma risk among dye users was significantly increased by 19% in comparison with never use (odds ratio (OR) = 1.19, 95% confidence interval (CI): 1.00, 1.41) and by 26% among persons who used hair dyes 12 or more times per year (OR = 1.26, 95% CI: 1.00, 1.60; p for linear trend = 0.414). Lymphoma risk was significantly higher among persons who had started coloring their hair before 1980 (OR = 1.37, 95% CI: 1.09, 1.72) and persons who had used hair dyes only before 1980 (OR = 1.62, 95% CI: 1.10, 2.40). Personal use of hair dyes is associated with a moderate increase in lymphoma risk, particularly among women and persons who used dyes before 1980. Specific compounds associated with this risk remain to be elucidated
    Type of Publication: Journal article published
    PubMed ID: 16731576
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: human ; neoplasms ; CLASSIFICATION ; EPIDEMIOLOGY ; NEW-YORK ; RISK ; SAMPLE ; SAMPLES ; INFECTION ; ASSOCIATION ; antibodies ; antibody ; virus ; LYMPHOMA ; ASSAY ; AGE ; LYMPHOCYTES ; case-control studies ; PREVALENCE ; EUROPE ; B-CELL LYMPHOMA ; HUMAN-IMMUNODEFICIENCY-VIRUS ; SERUM ; ADULT ; case-control study ; MALIGNANT-LYMPHOMA ; MIXED CRYOGLOBULINEMIA ; RECIPIENTS ; non-Hodgkin lymphoma ; analysis ; methods ; SUBTYPES ; ASSAYS ; USA ; B-CELL ; MALIGNANT-LYMPHOMAS ; LOW-GRADE ; non Hodgkin lymphoma ; VIRUS CORE PROTEIN ; CONSORTIUM ; red ; INTERLYMPH
    Abstract: Background & Aims: increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection. Methods: The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded. Results: HCV infection was detected in 172 NHL cases (3.60%) and in 169 (2.70%) controls (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.40 -2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95% CI, 1.44-4.23), diffuse large B-cell lymphoma (OR, 2.24; 95% CI, 1.682.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95% CI, 1.14-5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95% CI, 0.65-1.60). Conclusions: These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma)
    Type of Publication: Journal article published
    PubMed ID: 18387498
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Keywords: CANCER ; EXPRESSION ; Germany ; neoplasms ; DIAGNOSIS ; POPULATION ; RISK ; DISTINCT ; PROTEIN ; PROTEINS ; SAMPLE ; SAMPLES ; PATIENT ; RESPONSES ; INFECTION ; SERA ; ANTIGEN ; ANTIGENS ; T-CELL ; antibodies ; antibody ; ENTRY ; virus ; LYMPHOMA ; MALIGNANCIES ; PATTERNS ; AGE ; COUNTRIES ; DIVERSITY ; CANCER-PATIENTS ; case-control studies ; ANTIBODY-RESPONSES ; EPITOPE ; EPITOPES ; SERIES ; IMBALANCES ; CANCER PATIENTS ; EPSTEIN-BARR-VIRUS ; HODGKINS-DISEASE ; FOLLICULAR LYMPHOMA ; SERUM ; ELISA ; Epstein-Barr virus ; MALIGNANCY ; ONCOLOGY ; DISORDERS ; case control study ; case-control study ; SUBSET ; PATTERN ; BZLF1 ; VIRUS-INFECTION ; EBV INFECTION ; LEVEL ; case control studies ; INTERVAL ; analysis ; EVENTS ; leukaemia ; USA ; LOSSES ; EBV ; EVALUATE ; odds ratio ; RISK-FACTOR ; B-CELL ; case control ; CELL LYMPHOMAS ; Epstein Barr virus ; LATENT INFECTION ; MONONUCLEOSIS
    Abstract: Epstein-Barr Virus (EBV) is consistently associated with distinct lymphoproliferative malignancies and aberrant EBV antibody patterns are found in most EBV cancer patients. We evaluate the detection of an abnormal reactive serological pattern to EBV (ab_EBV) infection and the risk of lymphoma in a multicentric case-control study. Serum samples were collected at study entry from 1,085 incident lymphoma cases from Spain, France, Germany, Czech Republic, Italy and 1,153 age, sex and country matched controls. EBV immunoglobulin G (IgG) serostatus was evaluated through a peptide-based ELISA combining immunodominant epitopes of EBNA1 (BKRF1) and VCA-p18 (BFRF3). Further, immunoblot analysis was performed to evaluate distinct antibody diversity patterns to EBV early antigens (EA), besides EBNA1, VCA-p18, VCA-p40 (BdRF1) and Zebra (BZLF1). Patients with chronic active EBV infection and aberrant EBV activity were characterized as having an abnormal reactive pattern (ab_EBV). Ab EBV was observed in 20.9% of 2,238 included subjects with an increased proportion of cases presenting ab_EBV as compared to the control population (23.9% vs. 18.0% p = 0.001). Ab_EBV positivity was a risk factor for all lymphomas combined (odds ratio [OR] = 1.42, 95% confidence interval [CI]=1.15-1.74), and specifically for chronic lymphocytic leukaemia (OR = 2.96, 95%CI = 2.22-3.95). Lower levels of ab EBV were observed for follicular lymphoma (OR = 0.38, 95%-CI = 0.15-0.98). EBV may be involved in a larger subset of lymphomas among clinically immunocompetent subjects than previously thought, probably explained by an underlying loss of immune control of EBV latent infection. Ab_EBV is a useful too] to explore EBV imbalances preceeding or paralleling possible EBV associated oncogenic events. (C) 2007 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 17557295
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Keywords: CANCER ; CELLS ; neoplasms ; CT ; INFORMATION ; EPIDEMIOLOGY ; POPULATION ; RISK ; RISKS ; SAMPLE ; SAMPLES ; IDENTIFICATION ; LYMPHOMA ; HEALTH ; WOMEN ; hair dyes ; UNITED-STATES ; case-control studies ; non-Hodgkin lymphoma ; SUBTYPES ; USA ; N-ACETYLTRANSFERASE-1 ; non Hodgkin lymphoma ; non-Hodgkin ; CONSORTIUM ; N-ACETYLATION ; PHENYLENEDIAMINE
    Abstract: Personal use of hair dye has been inconsistently linked to risk of non-Hodgkin lymphoma (NHL), perhaps because of small samples or a lack of detailed information on personal hair-dye use in previous studies. This study included 4,461 NHL cases and 5,799 controls from the International Lymphoma Epidemiology Consortium 1988-2003. Increased risk of NHL (odds ratio (OR) = 1.3, 95% confidence interval (CI): 1.1, 1.4) associated with hair-dye use was observed among women who began using hair dye before 1980. Analyses by NHL subtype showed increased risk for follicular lymphoma (FL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) but not for other NHL subtypes. The increased risks of FL (OR = 1.4, 95% CI: 1.1, 1.9) and CLL/SLL (OR = 1.5, 95% CI: 1.1, 2.0) were mainly observed among women who started using hair dyes before 1980. For women who began using hair dye in 1980 or afterward, increased FL risk was limited to users of dark-colored dyes (OR = 1.5, 95% CI: 1.1, 2.0). These results indicate that personal hair-dye use may play a role in risks of FL and CLL/SLL in women who started use before 1980 and that increased risk of FL among women who started use during or after 1980 cannot be excluded
    Type of Publication: Journal article published
    PubMed ID: 18408225
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Keywords: Germany ; human ; MODEL ; EXPOSURE ; HEPATOCELLULAR-CARCINOMA ; HISTORY ; RISK ; RNA ; INFECTION ; FAMILY ; T cell ; T-CELL ; ASSOCIATION ; POLYMORPHISMS ; virus ; LYMPHOMA ; MALIGNANCIES ; AGE ; family history ; etiology ; COUNTRIES ; leukemia ; PATHOGENESIS ; REPLICATION ; case-control studies ; INDIVIDUALS ; PREVALENCE ; INTERVIEW ; MULTICENTER ; B-CELL LYMPHOMA ; immunoassay ; NON-HODGKINS-LYMPHOMA ; SERUM ; MALIGNANCY ; case-control study ; RE ; FAMILIES ; VIRUS-INFECTION ; LYMPHOPROLIFERATIVE DISORDERS ; MIXED CRYOGLOBULINEMIA ; METAANALYSIS ; case control studies ; INTERVAL ; ENZYME ; SUBTYPES ; LYMPHOMAS ; SIZE ; FAMILY-HISTORY ; EUROPEAN COUNTRIES ; odds ratio ; B-CELL ; EXPOSURES ; MULTICENTER CASE-CONTROL ; RARE ; SAMPLE-SIZE ; HCV INFECTION
    Abstract: Background & Aims: Increasing evidence points toward a role of hepatitis C virus (HCV) infection in the etiology of malignant lymphomas. However, previous epidemiologic studies were limited in size to establish an association between HCV infection and specific lymphoma subtypes. We performed a large, multicenter, case-control study to address this question. Methods: The study comprised 5 European countries and included newly diagnosed cases of any lymphoid malignancy recruited between 1998 and 2004. Controls were matched to cases by 5-year age group, sex, and study center. In-person interviews were conducted to collect data on demographic, medical, and family history as well as environmental exposures. Serum samples of 1807 cases and 1788 controls (excluding human immunodeficiency virus-positive and organ-transplantation subjects) were screened for HCV infection using an enzyme immunoassay. Positive as well as randomly selected negative samples were subjected to HCV RNA detection and HCV genotyping. Results: HCV infection was detected in 53 (2.9%) lymphoma cases and in 41 (2.3%) control subjects (odds ratio [OR], 1.42; 95% confidence interval [CI]: 0.93-2.15). Restricted to individuals who tested positive for HCV-RNA (indicating persistent infection and active viral replication), the OR was 1.82 (95% CI: 1.13-2.91). In subtype-specific analyses, HCV prevalence was associated with diffuse large B-cell lymphoma (OR, 2.19; 95% CI: 1.23-3.91) but not with chronic lymphocytic leukemia or follicular, Hodgkin's, or T-cell lymphoma. The sample size was not sufficient to derive any conclusions for rare lymphoma entities such as splenic marginal zone lymphoma. Conclusions: These results support a model that chronic HCV replication contributes to lymphomagenesis and establish a specific role of HCV infection in the pathogenesis of diffuse large B-cell lymphoma
    Type of Publication: Journal article published
    PubMed ID: 17087949
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...