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  • ddc: 610  (5)
  • ADHESION, ALLOGRAFTS, ALPHA(V)BETA(3), ALPHA(V)BETA(3) INTEGRIN, ALPHA-V-INTEGRINS, ANTAGONIST, ARRE  (1)
  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  HEC 2016: Health - Exploring Complexity; Joint Conference of GMDS, DGEpi, IEA-EEF, EFMI; 20160828-20160902; München; DOCAbstr. 765 /20160808/
    Publication Date: 2018-04-25
    Keywords: Standards and guidelines ; Data mapping ; Health Data Management and networking ; Advanced analytics and Big Data ; Clinical informatics ; Hospital information systems, computerized medical record systems ; Research IT infrastructures and EHR data reuse ; Data curation ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    Keywords: ADHESION, ALLOGRAFTS, ALPHA(V)BETA(3), ALPHA(V)BETA(3) INTEGRIN, ALPHA-V-INTEGRINS, ANTAGONIST, ARRE
    Abstract: Integrin-mediated cell adhesion and signaling is essential to vascular development and inflammatory processes. Elevated expression of integrin alpha(v)beta(3) has been detected in ischemia-reperfusion injury and rejecting heart allografts. We thus hypothesized that the inhibition of alpha(v)-associated integrins may have potent anti-inflammatory effects in acute kidney allograft rejection. We studied the effects of a peptidomimetic antagonist of alpha(v) integrins in two rat models of renal allotransplantation, differing in degree of major histocompatibility complex mismatch. Integrin alpha(v)beta(3) was up-regulated in rejecting renal allografts. Integrin antagonist reduced the histological signs of acute rejection, the intensity of the mononuclear cell infiltration, and cell proliferation in the grafted kidneys. This could be correlated to a reduced leukocyte-endothelial interaction and an improved peritubular microcirculation observed by intravital microscopy. In vitro under laminar flow conditions, the arrest of monocytes to interleukin-1 beta-activated endothelium was decreased. Furthermore, in co-culture models the proliferation and transmigration of monocytes/macrophages, endothelium, and fibroblasts induced by renal tubular epithelia was efficiently inhibited by alpha(v) integrin antagonism. These data reveal an important role of this integrin subclass in leukocyte recruitment and development and maintenance of acute rejection; blockade of alpha(v) integrins may provide a new therapeutic strategy to attenuate acute allograft rejection
    Type of Publication: Journal article published
    PubMed ID: 17702892
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 13; DOC08 /20180924/
    Publication Date: 2018-09-24
    Description: Introduction: Respiratory syncytial virus (RSV) and influenza virus infections are a significant healthcare risk for immunocompromised patients. In addition to community onset, nosocomial acquisition and transmission may also occur. Detection of asymptomatic shedders (e.g., patients in the incubation period or immunosuppressed long term shedders) facilitates control of nosocomial transmission.Methods: To strengthen the existing infection control concept, a PCR-based screening for RSV and influenza virus was implemented for all patients lacking respiratory symptoms (asymptomatic patients) who were hospitalized on an adult and a pediatric hemato-oncological ward. Laboratory results of this screening were analyzed retrospectively.Results: 665 respiratory specimens were obtained for screening from 251 patients (26% were 18 years and younger) from December 2016 to April 2017. In 23 patients without respiratory symptoms, either influenza virus or RSV infection was found, resulting in a detection rate of about 9%. In 6 patients, the infection was presumably detected during the incubation period, because an increase of viral load was observed in subsequent specimens. Positive screening results facilitated timely implementation of adequate infection control precautions. Nosocomial clusters of RSV or influenza were not detected during the screening period on the two wards.Conclusion: The seasonal screening program expanded our existing infection control concept in terms of patients lacking respiratory symptoms who shed influenza virus or RSV. It enabled us to identify 23 RSV or influenza infections in patients lacking respiratory symptoms in a 4-month period and thus to rapidly take isolation precautions.
    Description: Einleitung: Infektionen mit dem Respiratory Syncytial Virus (RSV) und dem Influenzavirus stellen für immunsupprimierte Patienten ein relevantes Gesundheitsrisiko dar. Die Infektion mit diesen Viren erfolgt häufig außerhalb des Krankenhauses, jedoch sind auch ein nosokomialer Erwerb und nosokomiale Übertragungen möglich. Die rechtzeitige Detektion von asymptomatischen Virusausscheidern (z.B. Patienten in der Inkubationsphase oder asymptomatische Langzeitausscheider bei Immunsuppression) kann dazu beitragen, die nosokomiale Verbreitung dieser Erreger zu verhindern.Methoden: Es wurde ein PCR-basiertes Screening-Programm für RSV und Influenza für alle Patienten ohne Symptome einer respiratorischen Erkrankung (asymptomatische Patienten) etabliert, die auf einer pädiatrischen hämatologisch-onkologischen und einer hämatologisch-onkologischen Station für Erwachsene behandelt wurden. Die Ergebnisse dieses Screening-Programms wurden retrospektiv analysiert. Ergebnisse: Von Dezember 2016 bis April 2017 wurden insgesamt 665 respiratorische Proben von 251 asymptomatischen Patienten (davon waren 26% pädiatrische Patienten) gewonnen. Bei 23 dieser Patienten konnte entweder eine RSV- oder eine Influenzainfektion nachgewiesen werden, was einer Detektionsrate von etwa 9% entspricht. 6 der Patienten, die eine ansteigende Viruslast im Verlauf aufwiesen, befanden sich beim Screening mutmaßlich in der Inkubationsphase. Positive Screening-Ergebnisse führten zur Implementierung zusätzlicher Hygienemaßnahmen (z.B. Isolation, Barrierepflege). Influenza und/oder RSV Häufungen wurden auf den beiden Stationen im Screening-Zeitraum nicht detektiert. Schlussfolgerung: Das saisonale Screeningprogramm hat unser bestehendes Hygienekonzept in der Hämatologie und Onkologie in Hinblick auf asymptomatische Virusausscheider erweitert. Es ermöglichte in einer etwa viermonatigen Periode insgesamt 23 asymptomatisch infizierte Patienten zu detektieren und für diese adäquate Hygienemaßnahmen zu ergreifen.
    Keywords: PCR ; screening ; respiratory syncytial virus ; influenza ; infection control ; cross infection ; oncology ; PCR ; Screening ; Respiratory Syncytial Virus ; Influenzavirus ; Hygiene ; nosokomiale Infektionen ; Onkologie ; ddc: 610
    Language: English
    Type: article
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); 20180902-20180906; Osnabrück; DOCAbstr. 188 /20180827/
    Publication Date: 2018-08-29
    Keywords: Medizinische Informatik ; Medizinische Dokumentation ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  HEC 2016: Health - Exploring Complexity; Joint Conference of GMDS, DGEpi, IEA-EEF, EFMI; 20160828-20160902; München; DOCAbstr. 746 /20160808/
    Publication Date: 2016-08-11
    Keywords: Standards and guidelines ; Data management in clinical trials ; eHealth and intersectoral documentation, health telematics, telemedicine ; Health Data Management and networking ; Clinical user interfaces, usability ; Clinical informatics ; Hospital information systems, computerized medical record systems ; Data curation ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 6
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); 20180902-20180906; Osnabrück; DOCAbstr. 241 /20180827/
    Publication Date: 2018-08-29
    Keywords: Medizinische Informatik ; Medizinische Dokumentation ; ddc: 610
    Language: English
    Type: conferenceObject
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