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Plasma enteroglucagon, peptide YY and gastrin in rats deprived of luminal nutrition, and after urogastrone-EGF administration. A proliferative role for PYY in the intestinal epithelium? (1989)

Goodlad, R. A. ; Ghatei, M. A. ; Domin, J. ; [et al.]

Springer

Cellular and molecular life sciences 45 (1989), S. 168-169

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ISSN: 1420-9071

Keywords: Intravenous (parenteral) nutrition ; gastrointestinal tract ; epithelium ; hormones ; glucagon ; enteroglucagon ; gastrin ; PYY ; Cell division ; cell proliferation ; growth control

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Intestinal tissue mass was significantly reduced throughout the gastrointestinal tract (p〈0.001) of intravenously fed (TPN) rats. Urogastrone-epidermal growth factor, (URO-EGF), reversed these changes. Although plasma enteroglucagon and gastrin levels showed a small increase with URO-EGF, this was far less than the gut tissue weight change, suggesting that it was unlikely that they were involved in modulating the proliferative response of the intestine to URO-EGF. Peptide tyrosine tyrosine (PYY) levels were however significantly increased by URO-EGF, indicating that PYY may possibly have a role in the modulation of intestinal cell proliferation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01954862

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Regional differences in concentrations of regulatory peptides in human colon mucosal biopsy (1989)

Calam, J. ; Ghatei, M. A. ; Domin, J. ; [et al.]

Springer

Digestive diseases and sciences 34 (1989), S. 1193-1198

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ISSN: 1573-2568

Keywords: colon ; colonic polyps ; vasoactive intestinal peptide ; somatostatin ; enteroglucagon

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The study was undertaken to examine regional differences in the concentrations of five regulatory peptides in the human colonic mucosa. Biopsies were obtained during routine colonoscopy from 33 patients whose colonic mucosa was macroscopically and histologically normal. Regulatory peptides were extracted, and measured by specific radioimmunoassays. Concentrations of three peptides that are present predominantly in endocrine cells within colonic mucosa increased significantly towards the rectum: Mean concentrations of peptide YY, enteroglucagon, and somatostatin were about three times greater in the rectum than in the cecum. However, concentrations of two peptides that are present in mucosal nerve fibers diminished significantly towards the rectum: Mean rectal concentrations of vasoactive intestinal peptide and peptide histidine methionine were both about 0.6 of mean cecal concentrations. Concentrations of all five peptides were lower in biopsies taken from colonic polyps than in normal colonic mucosa. Regional differences in colonic mucosal concentrations of regulatory peptides probably reflect differences in the physiological functions of different parts of the colon.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01537267

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