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  • Organic Chemistry  (12)
  • genetics  (5)
  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  59. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3. Joint Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch); 20080601-20080604; Würzburg; DOCDI.02.03 /20080530/
    Publication Date: 2008-05-30
    Keywords: aneurysm ; genetics ; homocysteine ; Aneurysma ; Genetik ; Homocystein ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  59. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3. Joint Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch); 20080601-20080604; Würzburg; DOCDI.03.09 /20080530/
    Publication Date: 2008-05-30
    Keywords: brain tumor ; genetics ; methionine ; Hirntumor ; Genetik ; Methionin ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
    Keywords: RECEPTOR ; EXPRESSION ; GROWTH ; GROWTH-FACTOR ; INVASION ; tumor ; CELL ; Germany ; PATHWAY ; PATHWAYS ; SYSTEM ; incidence ; GENE ; GENES ; meningioma ; SURGERY ; TRANSDUCTION ; ACTIVATION ; MECHANISM ; mechanisms ; DYNAMICS ; cell cycle ; CELL-CYCLE ; CYCLE ; signal transduction ; chromosome ; SIGNAL ; ACID ; TARGET ; hormone ; PROGRESSION ; COMPARATIVE GENOMIC HYBRIDIZATION ; MUTATION ; genetics ; SIGNAL-TRANSDUCTION ; inactivation ; PATHOGENESIS ; DAMAGE ; HEREDITARY ; MUTATIONS ; STRATEGIES ; TARGETS ; FUTURE ; RECEPTORS ; CYCLE CONTROL ; INITIATION ; 1p ; CHROMOSOMES ; molecular ; MOLECULAR-MECHANISM ; review ; TUMOR-SUPPRESSOR ; SUPPRESSOR GENE ; MALIGNANT PROGRESSION ; development ; MOLECULAR-MECHANISMS ; SUPPRESSOR ; MOLECULAR-GENETICS ; EVENTS ; telomere ; TELOMERASE ACTIVITY ; USA ; HORMONES ; LOSSES ; STEROID-HORMONES ; MOLECULAR PATHOGENESIS ; NERVOUS-SYSTEM TUMORS ; HUMAN BRAIN-TUMORS ; GRADING SYSTEM ; genomic ; GENETIC ALTERATION ; molecular genetics ; TUMOR-SUPPRESSOR GENES ; MAINTENANCE ; cell cycle control ; GROWTH-FACTORS ; refractory ; CASCADE ; CLINICAL-APPLICATIONS ; INTEGRITY ; ANAPLASTIC MENINGIOMAS ; meningioma progression ; meningioma therapy ; NF2 ; NF2 GENE ; RADIATION-INDUCED MENINGIOMAS ; SPORADIC MENINGIOMAS
    Abstract: TO REVIEW OUR CURRENT understanding of the molecular pathogenesis of meningiomas, to suggest topics for future investigations, and to present perspectives for clinical application. Significant progress has been made in recent years in delineating the molecular mechanisms involved in meningioma formation, growth, and malignant progression. However, many questions remain unanswered. Mutations in the NF2 gene probably account for the formation of more than half of all meningiomas. On the other hand, the molecular events underlying the initiation of meningiomas without NF2 mutations have yet to be identified. Investigating hereditary conditions associated with an increased meningioma incidence and the mechanisms underlying the development of radiation-induced meningiomas could potentially yield relevant insights. Meningioma growth is sustained by the dysregulated expression of steroid hormones, growth factors, their receptors, and activation of signal transduction cascades. The underlying genetic causes are unknown. Malignant progression of meningiomas probably involves the inactivation of tumor suppressor genes on chromosomes 1p, 9p, 10q, and 14q. However, with the possible exception of INK4A/INK4B, the actual targets of these chromosomal losses have remained largely elusive. Cell cycle dysregulation and telomerase activation have been recognized as important steps in meningioma progression. Telomere dynamics, cell cycle control, and the mechanisms responsible for deoxyribonucleic acid damage control are tightly interwoven. Investigating genes involved in the maintenance of genomic integrity might significantly deepen the understanding of meningioma progression. An area that has received relatively little attention thus far is the genetic background of meningioma spread and invasion. Possible clinical applications of the molecular data available may include a meningioma grading system based on genetic alterations, as well as therapeutic strategies for refractory meningiomas aimed at interfering with signal transduction pathways
    Type of Publication: Journal article published
    PubMed ID: 17460514
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  • 4
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    German Medical Science; Düsseldorf, Köln
    In:  57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; 20060511-20060514; Essen; DOCP 06.77 /20060508/
    Publication Date: 2006-07-31
    Keywords: glioblastoma multiforme ; genetics ; methionine synthase ; Glioblastom ; Genetik ; Methioninsynthase ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 5
    Keywords: brain ; tumor ; COMMON ; DISEASE ; POPULATION ; RISK ; GENE-EXPRESSION ; validation ; ASSOCIATION ; SUSCEPTIBILITY ; VARIANTS ; BREAST-CANCER ; DELETION ; genetics ; SNP ; RETINOIC ACID ; brain tumor ; VARIANT ; GLIOMA ; SNPs ; METAANALYSIS ; ALLELES ; USA ; NERVOUS-SYSTEM TUMORS ; GLIOBLASTOMA ; LOCI ; 8Q24 ; BIRTH-WEIGHT ; GENOME-WIDE ASSOCIATION ; Genetic ; Genome-wide association studies ; BRAIN-TUMOR
    Abstract: To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor
    Type of Publication: Journal article published
    PubMed ID: 19578367
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 342 (1905), S. 1-13 
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 15N-Labelled 3-(Dimethylamino)-2,2-dimethyl-2H-azirine for Mechanistic Studies of Reactions with NH-Acidic HeterocyclesThe synthesis of 3-(dimethylamino)-2,2-dimethyl(1-15N)-2H-azirine (1*) was accomplished via reaction of 1-chloro-N,N,2-trimethyl-1-propenylamine (9) and sodium (1-15N) azide (Scheme 3). The earlier reported reactions of 1 with saccharin (10, Scheme 4), phthalimide (12, Scheme 5), and 2H-1,3-benzoxazin-2,4(3H)-dione (16, Scheme 6) were repeated with 1*, and the position of the 15N-label in the products was determined by 15N-NMR spectroscopy. Whereas the postulated reaction mechanisms for 10 and 12 were confirmed by these experiments, the mechanism for the reaction of 16 had to be revised. With respect to the position of 15N in the products 17 and 18, a new mechanism is formulated in Scheme 7. Treatment of 5,5-dimethyl-1,3-oxazolidine-2,4-dione (19) with 1* led to 3,4-dihydro-2H-imidazol-2-on 20 in which only N(3) was labelled. The mechanism of a ring expansion and transannular ring contraction as shown in Scheme 8 is in agreement with this finding.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Dipolar 1:1 Adducts from the Reaction of 3-Amino-2H-azirines with 1,3,4-Oxadiazol- and 1,3,4-Thiadiazol-2(3H)-ones3-Amino-2H-azirines 1 react with 5-(trifluoromethyl)-1,3,4-oxadiazol-2(3H)-one (2) as well as with different 5-substituted 1,3,4-thiadiazol-2(3H)-ones (5a-e) in 2-propanol at room temperature to give dipolar 1:1 adducts of type 3 and 6, respectively, in reasonable-to-good yields (Schemes 3 and 6, Tab. 1 and 2). The structure of two of these dipolar adducts, 6a and 6e, which are formally donor-acceptor-stabilized azomethin imines, have been elucidated by X-ray crystallography (Figs. 1-4). In the reaction of 2 and sterically crowded 3-amino-2H-azirines 1c-e with a 2-propyl and 2-propenyl substituent, respectively, at C(2), a 4,5-dihydro-1,2,4-triazin-3(2H)-one of type 4 is formed as minor product (Scheme 3 and Table 1). Independent syntheses of these products proved the structure of 4. Several reaction mechanisms for the formation of compounds 3 and 4 are discussed, the most likely ones are described in Scheme 4: reaction of 2 as an NH-acidic compound leads, via a bicyclic zwitterion of type A, to 3 as well as to 4. In the latter reaction, a ring-expanded intermediate B is most probable.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Reaction of 3-(Dimethylamino)-2H-azirines with 1,3-Oxazolidine-2-thione to 3-(2-Hydroxyethyl)-2- thiohydantoinsThe reaction of 3-(dimethylamino)-2H-azirines 1 and 1,3-oxazolidine-2-thione (6), in MeCN at room temperature, yields, after hydrolytic workup, 3-(2-hydroxyethyl)-2-thiohydantoins 7 (Scheme 2). In the case of the spirocyclic 1c, crystallization of the crude reaction mixture leads to spiro [cyclopentane-1, 7′(7′aH)-imidazo [4, 3-b] oxazole] -5′-thione 8c. The mechanism is discussed.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 73 (1990), S. 599-607 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Reaction of 3-(Dimethylamino)-2H-azirines with 1,3-Benzoxazole-2(3H)-thioneThe reaction of 3-(dimethylamino)-2H-azirines 2 with 1,3-benzoxazole-2(3H)-thione (5), which can be considered as NH-acidic heterocycle (pKaca. 7.3), in MeCN at room temperature, leads to 3-(2-hydroxyphenyl)-2-thiohydantoins 6 and thiourea derivatives of type 7 (Scheme 2). A reaction mechanism for the formation of the products via the crucial zwitterionic intermediate A′ is suggested. This intermediate was trapped by methylation with Mel and hydrolysis to give 9 (Scheme 4). Under normal reaction conditions, A′ undergoes a ring opening to B which is hydrolyzed during workup to yield 6 or rearranges to give the thiourea 7. A reasonable intermediate of the latter transformation is the isothiocyanate E (Scheme 3) which also could be trapped by morpholine. In i-PrOH at 55-65° 2a and 5 react to yield a mixture of 6a, 2-(isopropylthio)-1,3-benzoxazole (12), and the thioamide 13 (Scheme 5). A mechanism for the surprising alkylation of 5 via the intermediate 2-amino-2-alkoxyaziridine Fis proposed. Again via an aziridine, e.g. H (Scheme 6), the formation of 13 can be explained.
    Type of Medium: Electronic Resource
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