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  • 1
    ISSN: 1432-0428
    Keywords: Hyperinsulinaemia ; insulin resistance ; insulin degradation ; haemochromatosis ; cirrhosis ; insulin ; glucagon ; C-peptide ; gastric inhibitory polypeptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study investigated early alterations of glucose metabolism in idiopathic haemochromatosis. Circulating concentrations of glucose, insulin, C-peptide, glucagon, and gastric inhibitory polypeptide (GIF) were measured after a 100-g oral glucose load in 10 men with idiopathic haemochromatosis in the non-cirrhotic stage of the disease. All had normal glucose tolerance and normal body weight. Ten matched healthy subjects were studied as controls. Insulin concentrations increased to significantly higher levels in patients with idiopathic haemochromatosis than in the control subjects from 30 to 180min after the glucose load (p〈0.01), while fasting insulin concentrations were not significantly different (p〉 0.05). Concentrations of glucose, glucagon, C-peptide, and GIF were not significantly different at any time (p〉 0.05). Thus, patients with idiopathic haemochromatosis show hyperinsulinaemia and hence insulin resistance without impaired glucose tolerance in the non-cirrhotic stage. Since pancreatic insulin secretion (C-peptide), glucagon secretion, and the entero-insulinar axis (GIP) are not impaired in these non-cirrhotic patients with idiopathic haemochromatosis, iron accumulation in the hepatocytes may be responsible for the impaired insulin effect and may cause impaired hepatic insulin extraction.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Insulin independent diabetes mellitus ; human pancreatic polypeptide ; glucagon ; control of diabetes ; insulin treatment ; protein meal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of the control of diabetes with diet and insulin upon plasma levels of human pancreatic polypeptide and glucagon was determined in eight patients with Type 2 (insulin independent) diabetes mellitus. The mean±SEM fasting plasma glucose was 15.9±1.3mmol/l for 5 days of diet treatment and 5.9±0.4 mmol/l for the last 5 days of treatment with diet plus insulin (p 〈 0.0001); corresponding fasting plasma pancreatic polypeptide levels were 328±97 and 247±71 pg/ml (p 〈 0.05) and immunoreactive glucagon levels were 95±11 and 62±6 pg/ml (p 〈 0.005). Cooked ground beef was administered on the first day of diet treatment and on the last day of treatment with diet plus insulin; mean maximal rise of pancreatic polypeptide, and total and incremental plasma pancreatic polypeptide response areas were significantly lower following treatment (p 〈 0.01), as was total area for immunoreactive glucagon (p 〈 0.05). Normalisation of fasting plasma glucose by short-term treatment with diet plus insulin is associated with decreases in basal and stimulated secretory activity of the pancreatic polypeptide cells in insulin independent diabetes mellitus.
    Type of Medium: Electronic Resource
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