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  • Antihypertensive therapy  (1)
  • human leukocyte antigens  (1)
  • 1
    ISSN: 1432-1041
    Keywords: Antihypertensive therapy ; alpha adrenoceptor blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Indoramin, a new antihypertensive drug shown to have cardioinhibitory and alpha adrenoceptor blocking activity in animals, was administered to patients with benign essential hypertension. Single oral doses between 0.1 and 1.0 mg/kg produced dose dependent falls in diastolic arterial pressure without increasing the heart rate. The arterial pressure response to intravenous noradrenaline was diminished in patients taking indoramin, but the response to intravenous angiotensin II and heart rate responses to intravenous isoprenaline were unaltered. Double blind cross-over comparison of indoramin with placebo in 8 patients on continuous oral therapy at maximally tolerated doses, 60–150 mg daily, showed that indoramin significantly lowered diastolic arterial pressure, but that the falls were modest, 7.6 mm Hg lying, 7.1 mm Hg standing and 9.3 mm Hg after exercise. The dose limiting side effect was sedation.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2592
    Keywords: Narcolepsy ; human leukocyte antigens ; immunoglobulin ; genetics ; restriction fragment length polymorphisms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Predisposition to narcolepsy involves genetic factors both in humans and in a canine model of the disorder. In humans, narcolepsy is strongly associated with HLA DR15 and DQB1*0602. In Dobermans and Labradors, narcolepsy is transmitted as a single autosomal recessive gene with full penetrance (canarc-1). Canine narcolepsy is not linked with DLA, the canine equivalent of HLA, but cosegregates with a DNA segment with high homology with theμ immunoglobulin heavy-chain (IgH) switch-like region (Sσ). To determine if the IgH locus is involved in genetic predisposition to human narcolepsy, restriction fragment length polymorphisms specific for the IgM and IgG cluster within this locus were studied in sporadic cases of the disease, as well as in five families with two or more affected individuals. Comparisons were made between control populations and both familial and sporadic cases and for patients with and without HLA-DR15 and DQB1*0602. RFLP analysis at the Sσ andγ-1 loci, which cover over 200 kb of 14q32.3, indicates that there is no evidence for any association between the IgH region and human narcolepsy.
    Type of Medium: Electronic Resource
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