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  • Articles  (3)
  • Articles: DFG German National Licenses  (3)
  • insulin action  (2)
  • Climate
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  • Articles  (3)
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  • Articles: DFG German National Licenses  (3)
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  • 1
    ISSN: 1573-4935
    Keywords: insulin binding ; insulin action ; human adipocytes ; phaeochromocytoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Insulin binding in adipocytes from patients with a phaeochromocytoma (PH) approached that of the controls (C) at low and higher concentrations of unlabeled insulin. The apparent receptor affinity was unchanged (ED50: PH 0.50×10−9M and C0.60×10−9M). Scatchard analysis of the binding data using the negative cooperative model revealed a 46% decrease in the total number of receptors together with no changes in both K−e (PH 0.55×109M−1 and C 0.36×109M−1) and K−f (PH 0.13×109 M−1 and C 0.07×109 M−1). According to the two site model, an altered proportion in the two classes of insulin binding sites was detected. This was accompanied by a catecholamine-desensitization of the adipocytes to the antilipolytic action of insulin. These events could represent a final situation of a chronic and endogeneous regulation by high levels of catecholamines of insulin receptors in human adipose tissue.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-4935
    Keywords: insulin binding ; insulin action ; adipocytes ; Cushing's syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Human adipocytes from patients with chronic endogenous hypercortisolism (Cushing's syndrome) showed a statistically significant decrease in insulin binding at low unlabelled-insulin concentrations but no change in receptor numbers (Cushing's 180,000±48,000 (3) receptors/cell and controls 189,000±30,000 (7)) together with a fourfold decrease in apparent receptor affinity (ED50: Cushing's 2.25×10−9 M and controls 0.57×10−9 M) and a decreased sensitivity to the antilipolytic effect of insulin. These events could represent the final situation of a chronic and endogenous regulation by high levels of cortisol of insulin receptors in human adipose tissue.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International journal of biometeorology 37 (1993), S. 113-124 
    ISSN: 1432-1254
    Keywords: History ; Climate ; Health ; Tourism ; Hippocratic corpus philosophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract This paper creates a framework for the study of the history of tourism for climate and health. It traces the ways in which people have both moved away from detrimental health conditions and towards places thought to provide climatic cures. It brings to light the complex issues that have affected the course of the tourist trade. In this way it helps to explain that the modern geographical distribution of the highly fashionable resort areas of the world owe a great deal to past and present interpretations of the HippocraticCorpus.
    Type of Medium: Electronic Resource
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