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  • 1
    ISSN: 1432-1041
    Keywords: Antihypertensive agents ; clonidine ; methyldopa ; hypertensive rebound ; side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The results of a titrated-dose cross-over comparison of clonidine with methyldopa are reported. Only one third of those entering the trial completed it. The blood pressure lowering effect of the two drugs is seen to be very similar. Patients experienced significantly more dry mouth whilst on clonidine but sedation was equally distributed over the two treatments. A hypertensive rebound occurred in some patients after sudden withdrawal of clonidine. The place of this new compound in routine management of hypertension is discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1041
    Keywords: trazodone ; imipramine ; anticholinergic effects ; ECG ; antidepressants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The electrocardiographic and anticholinergic effects of trazodone (150 mg) and imipramine (75 mg) were investigated in 8 healthy volunteers. Both agents increased the QTc interval and decreased T wave height, but the effects occurred earlier with trazodone (from 30 min onwards) than with imipramine (150 and 180 min after dosing). Both drugs decreased heart rate, imipramine at 30 and 60 min and trazodone at 90 min. After 120 min, heart rate began to increase with imipramine an effect which was not seen with trazodone. Salivary volume was significantly decreased by imipramine at 120 and 180 min whereas trazodone did not influence salivary volume. Plasma levels of trazodone and imipramine were significantly related to the decrease in T wave amplitude. The increase in QTc interval correlated significantly with the plasma level of imipramine. These results suggest that trazodone, like the tricyclic antidepressants prolongs ventricular repolarization; but, in contrast to imipramine, it does not have anticholinergic activity.
    Type of Medium: Electronic Resource
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