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  • p53  (2)
  • ADENOVIRUS  (1)
  • Dysgnathiechirurgie
  • biventricular pacing
  • 1
    Keywords: PEPTIDE ; CELLS ; EXPRESSION ; CELL ; Germany ; human ; IN-VIVO ; THERAPY ; VIVO ; SAMPLE ; SAMPLES ; INFECTION ; SERA ; DOMAIN ; BINDING ; LIMITATION ; antibodies ; antibody ; NEUTRALIZING ANTIBODIES ; virus ; IDENTIFICATION ; VECTORS ; VECTOR ; EFFICIENT ; TRAFFICKING ; REGION ; REGIONS ; SURFACE ; EPITOPE ; EPITOPES ; PREVALENCE ; adeno-associated virus ; TYPE-2 ; ADENOVIRUS ; AAV ; AAV2 VECTORS ; AFFINITY ; CANINE PARVOVIRUS ; DOMAINS ; EMPTY CAPSIDS ; NEUTRALIZATION ; immunogenic epitopes ; AAV antibodies ; human serum sampl
    Abstract: The high prevalence of human serum antibodies against adeno-associated virus type 2 (AAV) vectors represents a potential limitation for in vivo applications. Consequently, the development of AAV vectors able to escape antibody binding and neutralization is of importance. To identify capsid domains which contain major immunogenic epitopes, six AAV capsid mutants carrying peptide insertions in surface exposed loop regions (I-261, I-381, I-447, I-534, I-573, I-587) were analyzed. Two of these mutants, I-534 and I-573, showed an up to 70% reduced affinity for AAV antibodies as compared to wild-type AAV in the majority of serum samples. In addition, AAV mutant I-587 but not wild-type AAV efficiently transduced cells despite the presence of neutralizing antisera. Taken together, the results show that major neutralizing effects of human AAV antisera might be overcome by the use of AAV capsid mutants
    Type of Publication: Journal article published
    PubMed ID: 14625569
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  • 2
    ISSN: 1572-8595
    Keywords: biatrial pacing ; biventricular pacing ; pacemaker indication ; coronary sinus electrodes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The artificial activation of the heart modifies the mechanics of contraction and relaxation. While only little basic research has been addressed to this question, clinical observations showed that for hypertrophic as well as dilated cardiomyopathies appropriate pacing techniques can be useful. Pacing can influence the activation sequence. The spread out from a single site is slow, and so hypercontractility deminshed. With the use of multiple electrodes, two atrial and/or two ventricular, conduction delays in the atria or ventricles can be eliminated. Synchronisation of the cardiac activation has an anti-arrhythmic and positiv inotropic effect. This may lead to new indications for pacemakers or better to be named cardiac synchronisers.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0730-2312
    Keywords: carcinogenesis ; oral mucosa ; p53 ; hyperplastic lesions ; squamous cell carcinomas ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Hyperplastic lesions of the oral mucosa such as leukoplakia and oral lichan planus can eventually develop into squamous cell carcinomas. In the clinical treatment of these lesions it would be very important tobe able to predict the biological behaviour of an individual lesion. In 64 hyperplastic lesions and 85 squamous cell carcinomas of the oral mucosa, the expression of the mutant tumor suppressor gene p53and the grade of dysplasia of the lesions.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Orale Plattenepithelkarzinome ; p53 ; Biomarker ; Radiotherapie ; Key words Oral squamous cell carcinoma ; p53 ; Biomarker ; Radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Multimodal therapy of oral squamous cell carcinomas today is based on surgery, radiotherapy and chemotherapy. Despite the combination of all three therapeutic options, there is still a large number of treatment failures and therefore major questions remain. Recent investigations suggest that mutations of the p53 tumor supressor gene may account for some of the therapeutic failures. Inactivation of the gene may be an important determinant of the efficiacy of today’s multimodal therapy protocols. In 90 patients with squamous cell carcinomas of the oral cavity biopsy specimens were taken before and after preoperative radiochemotherapy. From all patients, biopsy and resection material was available for immunohistochemical analysis of p53. After radiation treatment, 51 patients (57%) showed a complete response; 39 patients (43%) only showed a partial response or did not respond at all. Among the responders, 82% of the pretherapeutic tumors were p53 positive, whereas among the nonresponders only 56% of the pretherapeutic tumors were p53 positive. The majority of the residual tumors were also p53 negative according to immunohistology after radiation treatment. In our study, detection of p53 protein by immunohistochemistry seemed to be connected with a more radiosensitive reaction of the tumors. Nevertheless, successful strategies for radiation therapy may need to take into account the tissue of origin and the status of p53 in the tumor.
    Notes: Trotz der seit einigen Jahrzehnten in der Behandlung der Mundhöhlenkarzinome eingesetzten Kombinationstherapie ist die Rezidivrate unverändert hoch. Jüngsten Untersuchungen an Plattenepithelkarzinomzellinien zufolge scheinen Mutationen des p53-Tumorsuppressorgens für einen Teil der Therapieresistenzen insbesondere in der Radiotherapie mitverantwortlich zu sein. In einer retrospektiven Studie wurde bei 90 Patienten mit Plattenepithelkarzinomen der Mundhöhle, die mit einer präoperativen Radiochemotherapie und nachfolgender Tumorresektion behandelt wurden, die p53-Exrpession vor und nach der Radiochemotherapie immunhistologisch untersucht und mit dem Ansprechen auf die Therapie korreliert. Nach der Radiochemotherapie waren bei 51 (57%) Patienten klinisch und histopathologisch im Operationsresektat keine Tumoranteile mehr nachweisbar. 39 (43%) Patienten zeigten keine oder nur eine geringe Reaktion auf die Therapie. Die therapiesensitiven Tumoren wiesen in den prätherapeutischen Biopsien in 82% der Fälle eine Expression des p53 auf, die therapieresistenten Tumoren lediglich in 56%. Nach Abschluß der Radiatio konnte nur noch in 4 der 39 Resttumoren p53 nachgewiesen werden. In unserer Untersuchung schien die Expression des p53-Gens mit einer erhöhten Therapiesensibilität einherzugehen.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-3940
    Keywords: Schlüsselwörter ; Dysgnathiechirurgie ; Operationssimulation ; Weichgewebesimulation ; Computersimulation ; Keywords ; Orthognathic surgery ; Preoperative planning ; Soft tissue simulation ; Computer-aided simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Background In addition to standard X-rays, photographic documentation, cephalometric and model analysis, a computer-aided, three-dimensional (3D) simulation system has been developed in close cooperation with the Institute of Communications of the Friedrich-Alexander-Universität Erlangen-Nürnberg. With this simulation system a photorealistic prediction of the expected soft tissue changes can be made. Prerequisites are a 3D reconstruction of the facial skeleton and a 3D laser scan of the face. After data reduction, the two data sets can be matched. Cutting planes enable the transposition of bony segments. The laser scan of the facial surface is combined with the underlying bone via a five-layered soft tissue model to convert bone movements on the soft tissue cover realistically. Conclusion Further research is necessary to replace the virtual subcutaneous soft tissue model by correct, topographic tissue anatomy.
    Notes: Hintergrund Im Rahmen eines Sonderforschungsbereichs der Deutschen Forschungsgemeinschaft (SFB 603) wurde in Zusammenarbeit mit dem Lehrstuhl für Nachrichtentechnik der Universität Erlangen-Nürnberg ein computergestütztes Simulationssystem zur dreidimensionalen, fotorealistischen Vorhersage von Weichgewebeveränderungen nach orthognathen Eingriffen entwickelt. Voraussetzung sind 3D-CT-Datensätze des Gesichtsschädels sowie eine ebenfalls dreidimensionale Laserabtastung der Gesichtsoberfläche. Beide Datensätze können nach Datenreduktion über ein mathematisches Verfahren so miteinander verknüpft werden, dass mit Hilfe so genannter “cutting planes” Verlagerungen von Knochensegmenten auf das bedeckende Weichgewebe realitätsnah übertragen werden können. Schlussfolgerung Es bedarf weiterer Forschungsanstrengungen, um auch die subkutanen Weichgewebelagen so in das Simulationsmodell zu integrieren, dass noch bestehende Abweichungen korrigiert werden können.
    Type of Medium: Electronic Resource
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