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  • 1
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Orale Plattenepithelkarzinome ; p53 ; Biomarker ; Radiotherapie ; Key words Oral squamous cell carcinoma ; p53 ; Biomarker ; Radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Multimodal therapy of oral squamous cell carcinomas today is based on surgery, radiotherapy and chemotherapy. Despite the combination of all three therapeutic options, there is still a large number of treatment failures and therefore major questions remain. Recent investigations suggest that mutations of the p53 tumor supressor gene may account for some of the therapeutic failures. Inactivation of the gene may be an important determinant of the efficiacy of today’s multimodal therapy protocols. In 90 patients with squamous cell carcinomas of the oral cavity biopsy specimens were taken before and after preoperative radiochemotherapy. From all patients, biopsy and resection material was available for immunohistochemical analysis of p53. After radiation treatment, 51 patients (57%) showed a complete response; 39 patients (43%) only showed a partial response or did not respond at all. Among the responders, 82% of the pretherapeutic tumors were p53 positive, whereas among the nonresponders only 56% of the pretherapeutic tumors were p53 positive. The majority of the residual tumors were also p53 negative according to immunohistology after radiation treatment. In our study, detection of p53 protein by immunohistochemistry seemed to be connected with a more radiosensitive reaction of the tumors. Nevertheless, successful strategies for radiation therapy may need to take into account the tissue of origin and the status of p53 in the tumor.
    Notes: Trotz der seit einigen Jahrzehnten in der Behandlung der Mundhöhlenkarzinome eingesetzten Kombinationstherapie ist die Rezidivrate unverändert hoch. Jüngsten Untersuchungen an Plattenepithelkarzinomzellinien zufolge scheinen Mutationen des p53-Tumorsuppressorgens für einen Teil der Therapieresistenzen insbesondere in der Radiotherapie mitverantwortlich zu sein. In einer retrospektiven Studie wurde bei 90 Patienten mit Plattenepithelkarzinomen der Mundhöhle, die mit einer präoperativen Radiochemotherapie und nachfolgender Tumorresektion behandelt wurden, die p53-Exrpession vor und nach der Radiochemotherapie immunhistologisch untersucht und mit dem Ansprechen auf die Therapie korreliert. Nach der Radiochemotherapie waren bei 51 (57%) Patienten klinisch und histopathologisch im Operationsresektat keine Tumoranteile mehr nachweisbar. 39 (43%) Patienten zeigten keine oder nur eine geringe Reaktion auf die Therapie. Die therapiesensitiven Tumoren wiesen in den prätherapeutischen Biopsien in 82% der Fälle eine Expression des p53 auf, die therapieresistenten Tumoren lediglich in 56%. Nach Abschluß der Radiatio konnte nur noch in 4 der 39 Resttumoren p53 nachgewiesen werden. In unserer Untersuchung schien die Expression des p53-Gens mit einer erhöhten Therapiesensibilität einherzugehen.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0730-2312
    Keywords: carcinogenesis ; oral mucosa ; p53 ; hyperplastic lesions ; squamous cell carcinomas ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Hyperplastic lesions of the oral mucosa such as leukoplakia and oral lichan planus can eventually develop into squamous cell carcinomas. In the clinical treatment of these lesions it would be very important tobe able to predict the biological behaviour of an individual lesion. In 64 hyperplastic lesions and 85 squamous cell carcinomas of the oral mucosa, the expression of the mutant tumor suppressor gene p53and the grade of dysplasia of the lesions.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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