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  • risk factors  (2)
  • 1
    Keywords: CANCER ; CELLS ; BLOOD ; CELL ; FOLLOW-UP ; INFORMATION ; COHORT ; cohort study ; DISEASE ; DISEASES ; HISTORY ; LONG-TERM ; POPULATION ; RISK ; SAMPLES ; HEART ; RISK-FACTORS ; CYCLE ; ASSOCIATION ; FREQUENCY ; FREQUENCIES ; HEALTH ; PLASMA ; WOMEN ; MEN ; risk factors ; smoking ; COUNTRIES ; COMPONENT ; DATABASE ; PRESSURE ; DIET ; nutrition ; SERUM ; ASSOCIATIONS ; RE ; fat distribution ; development ; EVENTS ; PLASMA-LEVELS ; prospective ; prospective study ; DIETARY ASSESSMENT METHODS ; RISK-FACTOR ; study protocol ; CORONARY-ARTERY-DISEASE ; EPIC heart ; HIGH BLOOD-PRESSURE ; NORFOLK COHORT
    Abstract: EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition ( EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition and major chronic disease outcomes. Its objective is to advance understanding about the separate and combined influences of lifestyle ( especially dietary), environmental, metabolic and genetic factors in the development of cardiovascular diseases by making best possible use of the unusually informative database and biological samples in EPIC. Between 1992 and 2000, 519,978 participants ( 366,521 women and 153,457 men, mostly aged 35 - 70 years) in 23 centres in 10 European countries commenced follow-up for causespecific mortality, cancer incidence and major cardiovascular morbidity. Dietary information was collected with quantitative questionnaires or semi-quantitative food frequency questionnaires, including a 24-h dietary recall sub-study to help calibrate the dietary measurements. Information was collected on physical activity, tobacco smoking, alcohol consumption, occupational history, socio-economic status, and history of previous illnesses. Anthropometric measurements and blood pressure recordings were made in the majority of participants. Blood samples were taken from 385,747 individuals, from which plasma, serum, red cells, and buffy coat fractions were separated and aliquoted for long-term storage. By 2004, an estimated 10,000 incident fatal and non-fatal coronary and stroke events had been recorded. The first cycle of EPIC-Heart analyses will assess associations of coronary mortality with several prominent dietary hypotheses and with established cardiovascular risk factors. Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors
    Type of Publication: Journal article published
    PubMed ID: 17295097
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  • 2
    Keywords: CANCER ; BLOOD ; carcinoma ; CELL ; Germany ; human ; FOLLOW-UP ; INFORMATION ; SUPPORT ; COHORT ; MORTALITY ; RISK ; RISKS ; HEALTH ; WOMEN ; OBESITY ; risk factors ; COUNTRIES ; UNITED-STATES ; BLOOD-PRESSURE ; HYPERTENSION ; EPIC ; nutrition ; RELATIVE RISK ; CELL CARCINOMA ; renal cell carcinoma ; INCREASE ; USA ; RISK-FACTOR ; KIDNEY CANCER ; INCREASES ; ANTIHYPERTENSIVE MEDICATION ; antihypertensive agents ; DIURETICS ; FERRIC NITRILOTRIACETATE ; kidney neoplasms ; RISING INCIDENCE
    Abstract: Elevated blood pressure has been implicated as a risk factor for renal cell carcinoma (RCC), but prospective studies were confined to men and did not consider the effect of antihypertensive medication. The authors examined the relation among blood pressure, antihypertensive medication, and RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Blood pressure was measured in 296,638 women and men, recruited in eight European countries during 1992-1998, 254,935 of whom provided information on antihypertensive medication. During a mean follow-up of 6.2 years, 250 cases of RCC were identified. Blood pressure was independently associated with risk of RCC. The relative risks for the highest versus the lowest category of systolic (〉= 160 mmHg vs. 〈 120 mmHg) and diastolic (〉= 100 mmHg vs. 〈 80 mmHg) blood pressures were 2.48 (95% confidence interval: 1.53, 4.02) and 2.34 (95% confidence interval: 1.54, 3.55). Risk estimates did not significantly differ according to sex or use of antihypertensive medication. Individuals taking antihypertensive drugs were not at a significantly increased risk unless blood pressure was poorly controlled. These results support the hypothesis that hypertension, rather than its medications, increases the risk of RCC in both sexes, while effective blood pressure control may lower the risk
    Type of Publication: Journal article published
    PubMed ID: 18048375
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