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  • 1
    ISSN: 1435-1803
    Keywords: regional myocardial ischemia ; lipid peroxidation ; scavenger action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dog experiments were performed to describe the time course of lipid peroxidation after various ischemic influences of the heart measured by formation of malondialdehyde (MDA), and the scavenger action determined by reduced glutathione (GSH) content and superoxide dismutase (SOD) activity. Experimental groups consisted of control dogs having intact hearts and dogs with acute ramus descendens anterior ligature (LAD) having ischemic areas through 15, 30, 45 minutes and 1, 2, 3, 24 hours. Heart tissue for biochemical assays was excised from both the ischemic areas and from nonischemic left ventricle. The acute ischemia caused characteristic alterations in the biochemical parameters: MDA level gradually increased with its peak value being found at the end of 3 hours ligature. GSH levels decreased moderately, whereas SOD levels reduced sharply. As incrcased MDA formation indicates breakdown of the polyunsaturated fatty acids (PUFA) in the membranes and decreaased GSH and SOD levels indicate impairment of the natural scavengering, the observed changes clearly outline the extent of disintegration of membrane structure and function.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1803
    Keywords: myocardial infarct ; lipid peroxidation ; free oxygen radicals ; scavenger action ; synthetic antioxidant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experiments were performed on dog hearts following coronary ligation and treatment with synthetic antioxidant of dihydroquinoline type. Experimental groups were: (i) control dogs, (ii) dogs with ligation of descendens anterior coronary branch, (iii) coronary ligated dogs with antioxidant pretreatment and (iv) dogs with coronary ligation and simultaneous antioxidant infusion therapy. The heart infarctionper se is accompanied by the disintegration of membrane polyunsaturated fatty acids expressed by increase of malondialdehyde (MDA) concentration and the impairment of natural scavenging characterized by the decrease of superoxide dismutase (SOD) and reduced glutathione (GSH) content. The oral pretreatment with antioxidant for 8 days prevented or decreased the unfavourable pathobiochemical responses. The acute infusion therapy exerted no immediate protection, nonetheless, it could decrease the severity of pathological signs.
    Type of Medium: Electronic Resource
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