Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Chemical Engineering  (3)
  • substituted anthraquinones  (1)
  • 1980-1984  (3)
  • 1965-1969  (1)
Collection
Publisher
Years
Year
  • 1
    ISSN: 1573-0646
    Keywords: substituted anthraquinones ; cytotoxicity ; structure-activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A number of substituted anthraquinones (SAQs) are currently being tested as cancer chemotherapeutic agents because of their structural similarity to Adriamycin (ADR) and other DNA-intercalating antibiotics. In this study, the effect of SAQs on the induction of cytotoxicity of asynchronous Chinese hamster cells in culture was studied and compared to those produced by ADR and dihydroxyanthraquinone (DHAQ), a SAQ previously shown to be more effective than ADR. SAQs produced cytotoxicity that was dependent upon the concentration and duration of drug exposure. A correlation was noted between the activity of a compound (the concentration required to produce a certain level of cell kill) and the presence of a particular triangular arrangement of one nitrogen atom and two oxygen atoms. There was also a correlation between chemical structure and antitumor activity in the murine P388 leukemia model system. This correlation between chemical structure and biological activity may aid in the development of new SAQs with greater potential as cancer chemotherapeutic agents.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 13 (1967), S. 739-744 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Normal freezing of several organic systems exhibiting simple eutectic behavior has been studied experimentally, and the occurrence of constitutional subcooling has been clearly established. This phenomenon, previously observed in systems of metallurgical interest, results in the instability of a planar solid-liquid interface and leads to solute trapping. This trapping mechanism quantitatively explains why eutectic forming systems exhibit solid phase concentration profiles identical to those expected of systems which form solid solutions. The onset of constitutional subcooling can be correlated and reliably predicted by theoretical equations.Although the process of normal freezing with no liquid phase agitation would appear to be well described by a diffusion model, free convection induced by concentration gradients renders a boundary-layer model more appropriate when the liquid density of the solvent exceeds that of the solute and freezing is in an upward direction.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 30 (1984), S. 765-769 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An experimental study has been made for laminar mass transfer to a rotating disk and a rotating hemispherical electrode when sinusoidal alternating current (AC) together with direct current (DC) are flowing across the electrode/electrolyte interface. A resistor-capacitor circuit was used to measure the phase shift between the applied AC and the resulting periodical concentration overpotential. The limiting AC current density corresponding to a zero instantaneous surface concentration was determined as a function of AC frequency and DC current density. The experimental data agreed with the theoretical calculations in a regime of a dimensionless AC frequency K = (ω/Ω)Sc1/3 greater than 1 and less than 200.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A film model is presented for the analysis of mass transfer to a rotating hemispherical electrode when sinusoidal alternating current (AC) together with direct current (DC) are flowing across the electrode surface. The concentration of a diffusing ion is separated into two independent components: a constant DC component and a periodic AC component. The DC concentration is obtained by solving the steady-state convective mass transport equation with the perturbation method. The periodic AC concentration distribution is analyzed by the solution to the one-dimensional transient diffusion equation based on the concept of Nernst diffusion layer. The limiting AC current densities corresponding to a zero surface concentration of a reactive ion are investigated for various DC current densities and AC frequencies. The resulting periodic concentration overpotential wave and its phase shift with respect to the applied AC are examined. A comparison with a previous rigorous model indicates that the film model is a good approximation to the mass transfer calculation in the regimes of a dimensionless AC frequency K = (ω/Ω)Sc1/3 greater than 2 and less than 0.01.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...