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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20140511-20140514; Dresden; DOCMO.03.02 /20140513/
    Publication Date: 2014-05-14
    Keywords: thermography ; tumor ; intraoperative ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
    Keywords: SPECTRA ; CANCER ; Germany ; human ; SUPPORT ; COHORT ; GENOME ; PATIENT ; DNA ; INFECTION ; SKIN ; PCR ; HPV ; BETA ; PREVALENCE ; immunosuppression ; SKIN-CANCER ; papillomaviruses ; GAMMA ; RECIPIENTS ; VIRAL LOAD ; allergy ; cutaneous HPV ; HUMAN PAPILLOMAVIRUSES ; HPV types ; 33 ; ALLERGIES ; organ transplant recipients ; RANGE ; cutaneous warts
    Abstract: BACKGROUND: A broad spectrum of human papillomaviruses (HPV) has been detected in warts from immunocompetent patients and a much more diverse range from immunosuppressed organ transplant recipients (OTR). OBJECTIVES: To determine the HPV types in warts from OTR, we assessed present infections of mucosal (alpha-PV), wart-associated (alpha-, micro- and nu-PV) and cutaneous HPV types (beta-/gamma-PV) in immunocompetent patients and OTR. Patients/methods Forty-one warts from 29 immunocompetent patients (non-OTR) and 53 warts from 33 OTR were analysed for DNA of human alpha-, beta-, gamma-, micro- and nu-PV. For frequent types viral load was determined by quantitative real-time PCR. RESULTS: Compared with non-OTR prevalence of cutaneous HPV (79% vs. 49%, P 〈 0.01) and the number of multiple infections (62% vs. 17%, P 〈 0.0001) were significantly increased. The mean viral load of the wart-associated HPV was more than 10(5)-fold higher compared with human beta-PV in both cohorts. CONCLUSIONS: The high load of wart-associated HPV suggests an active role of these viruses rather than cutaneous types in warts independent of immunosuppression; however, the substantial fraction of warts with low HPV genome copies remains to be explained.
    Type of Publication: Journal article published
    PubMed ID: 19519829
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  • 3
    Keywords: OPTIMIZATION ; PEPTIDE ; INHIBITOR ; tumor ; CELL ; INHIBITION ; KINASE ; MICROSCOPY ; MODEL ; MODELS ; SUPPORT ; SYSTEM ; SYSTEMS ; TOOL ; TUMORS ; ACTIVATION ; cell signaling ; DOMAIN ; BIOLOGY ; CYCLE ; ASSAY ; DESIGN ; PARAMETERS ; RECRUITMENT ; STRATEGIES ; lipids ; UNCERTAINTY ; parameter estimation ; systems biology ; BEHAVIOR ; AFFINITY ; AKT ; REPRESENTATION ; signaling ; PROTOCOL ; FLUORESCENCE MICROSCOPY ; PROFILES ; USA ; COMPOUND ; KINASE INHIBITOR ; lipid ; CALIFORNIA ; STATE ; STRATEGY ; A KINASE ; EXPERIMENTAL-DESIGN ; RANGE ; PI3K ; chemically induced
    Abstract: Differential equation models that describe the dynamic changes of biochemical signaling states are important tools to understand cellular behavior. An essential task in building such representations is to infer the affinities, rate constants, and other parameters of a model from actual measurement data. However, intuitive measurement protocols often fail to generate data that restrict the range of possible parameter values. Here we utilized a numerical method to iteratively design optimal live-cell fluorescence microscopy experiments in order to reveal pharmacological and kinetic parameters of a phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) second messenger signaling process that is deregulated in many tumors. The experimental approach included the activation of endogenous phosphoinositide 3-kinase (PI3K) by chemically induced recruitment of a regulatory peptide, reversible inhibition of PI3K using a kinase inhibitor, and monitoring of the PI3K-mediated production of PIP(3) lipids using the pleckstrin homology (PH) domain of Akt. We found that an intuitively planned and established experimental protocol did not yield data from which relevant parameters could be inferred. Starting from a set of poorly defined model parameters derived from the intuitively planned experiment, we calculated concentration-time profiles for both the inducing and the inhibitory compound that would minimize the predicted uncertainty of parameter estimates. Two cycles of optimization and experimentation were sufficient to narrowly confine the model parameters, with the mean variance of estimates dropping more than sixty-fold. Thus, optimal experimental design proved to be a powerful strategy to minimize the number of experiments needed to infer biological parameters from a cell signaling assay.
    Type of Publication: Journal article published
    PubMed ID: 19911077
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC); 20070426-20070429; Leipzig; DOCSA.06.02 /20070411/
    Publication Date: 2007-04-04
    Keywords: ultrasound ; registration ; aneurysm ; Ultraschall ; Neuronavigation ; Aneurysma ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 5
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC); 20070426-20070429; Leipzig; DOCP 026 /20070411/
    Publication Date: 2007-04-04
    Keywords: image registration ; free form deformation ; aneurysm ; Registrierung ; freie Deformation ; Aneurysma ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 6
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC); 20070426-20070429; Leipzig; DOCSA.06.01 /20070411/
    Publication Date: 2007-04-04
    Keywords: aneurysm ; imaging ; coregistration ; Aneurysma ; Bildgebung ; Koregistrierung ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 7
    ISSN: 1433-0407
    Keywords: Schlüsselwörter ALS ; Neurogenetik ; Exzitatorische Aminosäuren ; Cu/Zn-SOD ; Key words Amyotrophic lateral sclerosis ; Neurogenetics ; Excitatory amino acids ; Cu/Zn SOD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary At presently, the etiology and pathogenesis of amyotrophic lateral sclerosis (ALS) are unknown. In recent years, the genetic background of hereditary motor neuron diseases has been partly defined. In particular, these advances represent an opportunity to improve our understanding of the pathogenesis of the familial and sporadic forms of ALS and thus provide a basis for rational therapeutic approaches. In this article, recent findings on the pathogenesis of the familial form of ALS and their implications for the sporadic form are discussed.
    Notes: Zusammenfassung Die Ätiologie und Pathogenese der amyotrophen Lateralsklerose (ALS) bleibt weitgehend ungeklärt. In den zurückliegenden Jahren sind bei den genetisch bedingten Varianten dieser Erkrankung wichtige Fortschritte bei der Identifizierung ihrer molekularbiologischen Grundlagen gemacht worden. Diese Fortschritte berechtigen zu der Hoffnung, daß es in Zukunft gelingt, die Pathogenese der familiären, aber auch der sporadischen Formen der Erkrankung zu erhellen und damit rationalen Therapieansätzen weiter den Weg zu bereiten. Im Rahmen dieser Übersichtsarbeit soll sowohl auf die vorliegenden Befunde bei der familiären Form der ALS (fALS) als auch auf die mögliche Bedeutung dieser Befunde für pathogenetische Vorstellungen bei der sporadischen Form der ALS (sALS) eingegangen werden.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1459
    Keywords: Key words Amyotrophic lateral sclerosis ; Cu/Zn SOD ; EAAT2 ; AMPA ; Neurolathyrism ; Riluzole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is well accepted that excitotoxic mechanisms contribute to the pathogenesis of acute neuronal death in stroke, epilepsy, or brain trauma. It is less widely acknowledged that excitotoxic mechanisms play a role in the pathogenesis of chronic neurological disorders, in particular neurodegenerative diseases. However, evidence is accumulating that this mechanism is indeed part of the pathogenesis of late-onset neurodegenerative diseases. One of the clinical examples may be amyotrophic lateral sclerosis, a disease in which antiexcitotoxic strategies have neuroprotective effects in both, an established animal model and in man. In addition, there is accumulating neuropathological, pathobiochemical and pathophysiological evidence which indicates that excitotoxic mechanisms are part of the pathogenesis of the human disease and consequently part of the mechanisms explaining selective vulnerability (“pathoclisis”) in the human motor system.
    Type of Medium: Electronic Resource
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