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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  20. Wissenschaftliche Jahrestagung der DGPP; 20030912-20030914; Rostock; DOCP23 /20030912/
    Publication Date: 2003-09-12
    Description: Wir stellen die audiometrischen und molekulargenetischen Befunde einer Familie mit DFNA 6/14 vor. Bei der Erkrankung handelt es sich um eine mittelgradige sensorische Tief-Mitteltonschwerhörigkeit, die autosomal dominant vererbt wird. Die erhobenen audiometrischen Befunde stimmen mit den zu DFNA 6/14 bisher publizierten Daten überein. Mit Hilfe der molekulargenetischen Analyse konnte eine neue Missense Mutation des WFS1-Gens aufgedeckt werden. Dieses Gen ist auch als auslösende Ursache des Wolfram-Syndroms Typ 1 (WFS1), welches auch als DIDMOAD-Syndrom (Diabetes mellitus, Diabetes insipidus, Opticusatrophie, Schwerhörigkeit) bezeichnet wird, bekannt (Inoue et al. 1998, ). Auf Grundlage bisher bekannter Daten kann angenommen werden, daß bei WFS1-Patienten (autosomal rezessiver Erbgang) ein Hochton-Empfindungshörverlust auftreten kann . Demgegenüber zeigen autosomal dominant betroffene Patienten einen sensorischen Tief-Mitteltonhörverlust . Die molekulargenetischen und audiometrischen Befunde der hier untersuchten Familie werden dargestellt. Weitere Untersuchungen fokussieren den pathogenetischen Effekt der Mutation resp. des durch die Mutation betroffenen Proteins.
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  10. Jahrestagung der Gesellschaft für Arzneimittelforschung und Arzneimittelepidemiologie (GAA); 20031016-20031017; Bonn; DOC03gaa08 /20031016/
    Publication Date: 2003-10-15
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science; Düsseldorf, Köln
    In:  20. Wissenschaftliche Jahrestagung der DGPP; 20030912-20030914; Rostock; DOCP28 /20030912/
    Publication Date: 2003-09-12
    Description: Ein Zusammenhang zwischen Sprachentwicklung und Konzentrationsfähigkeit gilt als immer wahrscheinlicher. In der Diagnostik und Behandlung sprachentwicklungsverzögerter Kinder spielt deshalb die Beurteilung von Aufmerksamkeit und Konzentrationsfähigkeit eine zunehmende Rolle. Ein entsprechender Konzentrationstest steht derzeit allerdings noch nicht zur Verfügung. Wir haben das Marburger Konzentrations-Untersuchungsverfahren für Vorschulkinder (MKVK) in Anlehnung an das Konzentrations-Handlungs-Verfahren von Koch und Pleissner entwickelt und bereits vorgestellt. Es wurde zunächst an gesunden, später dann an schwerhörigen und auditiv wahrnehmungsgestörten Kindern erprobt. Hierbei zeigten sich hinsichtlich der benötigten Zeit und der Fehlerzahl signifikante Unterschiede zwischen der auffälligen und der unauffälligen Gruppe. In einer Folgeuntersuchung haben wir 57 sprachentwicklungsverzögerte Vorschulkinder aus zwei unterschiedlichen Populationen mit dem selben Konzentrationsverfahren getestet und diese mit 56 unauffälligen Kindern verglichen. Auch hier konnten signifikante Unterschiede bezüglich der Fehlerrate und der Zeit festgestellt werden. Mit diesen Ergebnissen wird erneut nachgewiesen, dass das von uns entwickelte Untersuchungsverfahren eine gute Möglichkeit bietet, Aussagen zur Konzentrationsfähigkeit bei Vorschulkindern abgeben zu können. Wir empfehlen deshalb dieses Verfahren für den Einsatz in der täglichen Praxis.
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
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    German Medical Science; Düsseldorf, Köln
    In:  67. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 89. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 44. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20031111-20031116; Berlin; DOC03dguX-19 /20031111/
    Publication Date: 2003-11-11
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
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    German Medical Science; Düsseldorf, Köln
    In:  67. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 89. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 44. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20031111-20031116; Berlin; DOC03dguX-14 /20031111/
    Publication Date: 2003-11-11
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 6
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The sodium-vitamin C co-transporter SVCT2 is primarily responsible for the accumulation of the important antioxidant ascorbate into brain cells. In vitro studies have demonstrated strong expression of this transporter in cultured astrocytes, whereas in situ hybridization analysis has so far detected SVCT2 only in neurons. In the present study, we examined the response of SVCT2 mRNA expression in the brain to focal ischemia induced for 2 h by unilateral middle cerebral artery occlusion. The mRNA expression patterns of SVCT2 and the glutamate-activated immediate early gene Arc were investigated at 2 and 22 h after ischemia. SVCT2 and Arc mRNA expression was lost in the ischemic core at both time points. In areas outside the core, Arc was strongly up-regulated, primarily at 2 h, whereas SVCT2 showed an increase at 2 and 22 h. SVCT2 expression was increased in neurons as well as in astrocytes, providing the first evidence for SVCT2 expression in astrocytes in situ. These findings underscore the importance of ascorbate as a neuroprotective agent and may have implications for therapeutic strategies. In addition, the increase of SVCT2 in astrocytes after ischemia suggests that cultured astrocytes are exposed to chronic oxidative stress.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Recent studies of antidandruff shampoos or tonics containing antifungal or antibacterial agents produced effects suggestive of a potential hair growth benefit.Objectives  The purpose of this 6-month, 200-patient, randomized, investigator-blinded, parallel-group clinical study was to assess the hair growth benefits of a 1% pyrithione zinc shampoo. The efficacy of a 1% pyrithione zinc shampoo (used daily), was compared with that of a 5% minoxidil topical solution (applied twice daily), a placebo shampoo and a combination of the 1% pyrithione zinc shampoo and the 5% minoxidil topical solution.Methods  Two hundred healthy men between the ages of 18 and 49 years (inclusive) exhibiting Hamilton–Norwood type III vertex or type IV baldness were enrolled. Total hair counts, the primary efficacy measure, were obtained using fibre-optic microscopy and a computer-assisted, manual hair count method. Secondary measures of efficacy included assessments of hair diameter, as well as patient and investigator global assessments of improvement in hair growth. These were based on photographs of the scalp using both midline and vertex views.Results  Hair count results showed a significant (P 〈 0·05) net increase in total visible hair counts for the 1% pyrithione zinc shampoo, the 5% minoxidil topical solution, and the combination treatment groups relative to the placebo shampoo after 9 weeks of treatment. The relative increase in hair count for the 1% pyrithione zinc shampoo was slightly less than half that for the minoxidil topical solution and was essentially maintained throughout the 26-week treatment period. No advantage was seen in using both the 5% minoxidil topical solution and the 1% pyrithione zinc shampoo. A small increase in hair diameter was observed for the minoxidil-containing treatment groups at week 17. Assessments of global improvements by the patients and investigator generally showed the benefit of 5% minoxidil. The benefit of the 1% pyrithione zinc shampoo used alone tended (P 〈 0·1) to be apparent only to the investigator.Conclusions  Hair count results show a modest and sustained improvement in hair growth with daily use of a 1% pyrithione zinc shampoo over a 26-week treatment period.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The surface structure, in particular the surface roughness, and the surface chemistry of titanium implants influence their anchoring in bone. The aim of this study was to analyse metal–bone contact (MBC) after modification of the implant surface, using different materials for blasting. The surface modification of titanium was produced by blasting it with particles made of Al2O3 or bioceramics. The biological effects were then investigated experimentally using 27 rabbits, analysed after 7, 28 and 84 days after the implantation of titanium cylinders treated accordingly. The MBC showed a tendency for more bone after bioceramics were used as a blasting material, compared to Al2O3.
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  • 9
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Recently, a species-dependent distribution of melatonin binding sites have been found in lamina I–V and lamina X of the spinal cord. In order to learn more about the function of spinal melatonin receptors, we investigated (i) the gene expression for melatonin receptor subtypes in lumbar and thoracal spinal cord tissue by means of the reverse-transcriptase polymerase chain reaction (RT-PCR) technique, and (ii) the electrophysiological and pharmacological properties of melatonin receptors heterologously expressed in Xenopus oocytes after injection of spinal cord mRNA by means of the voltage clamp technique. Because ample evidence indicates an antinociceptive effect of melatonin, (iii) the role of spinal melatonin receptors for maintaining mechanical and thermal hyperalgesia was studied in a rat model for postoperative pain. The RT-PCR data revealed that transcripts for MT1 and MT2 melatonin receptors are present in the dorsal and ventral horn of lumbar and thoracal spinal cord tissue. Injection of mRNA from lumbar spinal cord tissue into Xenopus oocytes led to the functional reconstitution of melatonin receptors which activate calcium-dependent chloride inward currents. Melatonin responses were abolished by simultaneous administration of the antagonists, 2-phenylmelatonin and luzindole and were unaffected by the MT2 antagonist 4-phenyl-2-propionamidotetralin. Intrathecal administration of different melatonin doses (10–100 nmol) did not inhibit mechanical or thermal hyperalgesia. However, intrathecal application of a low dose of morphine together with melatonin caused a brief antinociceptive effect suggesting an enhanced morphine analgesia by melatonin. In conclusion, the present study demonstrated for the first time the presence of transcripts of MT1 and MT2 receptors located in the dorsal and ventral horn of the spinal cord. Furthermore, spinal melatonin enhanced the antinociceptive effect of morphine indicating that melatonin acts as a neuromodulator in the spinal cord.
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  • 10
    ISSN: 1434-6036
    Keywords: PACS. 78.20.-e Optical properties of bulk materials and thin films – 71.45.Lr Charge-density-wave systems – 74.25.Gz Optical properties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: We present a comprehensive analysis of the optical constants of the two-dimensional dichalcogenide materials 2 H - TaSe 2 and 2 H - NbSe 2 , in an attempt to address the physics of two-dimensional correlated systems. The title compounds were studied over several decades in frequency, from the far-infrared to the ultraviolet. Measurements with linearly polarized light have allowed us to obtain both the in-plane and out-of-plane components of the conductivity tensor. Although the electromagnetic response of dichalcogenides is strongly anisotropic, both the in-plane and out-of-plane components of the conductivity tensor share many common features, including the presence of a well-defined metallic component, as well as a “mid-infrared band”. We discuss the implications of these results in the context of the spectroscopic results of other classes of low-dimensional conductors such as the high-temperature superconducting cuprates. In particular, the analysis of the redistribution of the spectral weight as a function of temperature, as well as the behavior of the quasiparticles relaxation rate, points to significant distinctions between the charge dynamics of dichalcogenides and other classes of low dimensional conductors.
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