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  • 1
    ISSN: 0309-1651
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    ISSN: 0309-1651
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters A 78 (1980), S. 22-24 
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
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  • 4
    ISSN: 1432-2307
    Keywords: Endocrine tissues ; Endocrine tumours ; Cytoskeleton ; Immunohistochemistry ; Gel-electrophoresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence and distribution of intermediate filament proteins, such as cytokeratins, vimentin, neurofilament proteins and glial fibrillary acidic protein were assessed immunohistochemically in pituitary adenomas, medullary thyroid carcinomas, endocrine pancreatic tumours, gastric, intestinal and bronchial carcinoids, parathyroid adenomas, pheochromocytomas, paragangliomas and related non-neoplastic tissues. In some cases, immunohistochemical results were correlated with cytoskeletal proteins as analysed by SDS-polyacrylamide gel electrophoresis. Cytokeratin antibodies with broad range of immunoreactivity (i.e. to murine liver cytokeratin component D) reacted with epithelial cells in all non-neoplastic endocrine tissues and related neuroendocrine tumours studied, except for adrenal medulla, pheochromocytoma and paraganglioma, independently of hormone production and biological behaviour. In contrast, antibodies to epidermis-derived cytokeratins failed to stain endocrine tissues and tumours. Paranuclear cytokeratin accumulations were seen in bronchial, gastric, and intestinal carcinoids and seem to be a common feature of neuroendocrine tumours. One-and two-dimensional SDS-polyacrylamide gel electrophoresis of non-neoplastic endocrine tissues and related tumours revealed two major keratin polypeptides corresponding to cytokeratins No. 8 and 18 of the cytokeratin catalog of human cells (Moll et al. 1982). According to this cytokeratin polypeptide composition, endocrine tissues and related tumours conform to the “simple type” of epithelia. Vimentin-related immunoreactivity was restricted to stromal cells and to folliculo-stellate cells in normal pituitary gland, Schwann cells in carcinoids and satellite cells in normal adrenal medulla and in pheochromocytomas. Neurofilament protein- (70 kD)-antibodies only stained nerve fibers in normal tissues and at the periphery of carcinoid tumour cell complexes, and, to a variable degree, cells in nontumorous adrenal medulla, pheochromocytomas and paragangliomas. Furthermore, neurofilament reactivity was observed along with cytokeratin expression in two bronchial carcinoids.
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  • 5
    ISSN: 1432-2307
    Keywords: Gastrointestinal carcinomas ; Tissue polypeptide antigen (TPA) ; Cytokeratins ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence and distribution of tissue polypeptide antigen (TPA) were assessed in gastrointestinal carcinomas of different origin, morphology and degree of differentiation. Immunocytochemistry was employed, using the PAP technique on formalin-fixed, paraffin-embedded material and compared with the results obtained with antibodies to cytokeratins. Like cytokeratins, TPA was a reliable marker of epithelial differentiation and showed tissue distribution patterns similar to cytokeratins, as revealed by antibodies with broad-range cytokeratin immunoreactivity. In most carcinomas, TPA-specific immunostaining was less intense than in non-neoplastic tissue. No direct relationship between intensity of TPA staining and morphological degree of differentiation and proliferation was found. TPA staining was most pronounced at the periphery of the cells. In stratified epithelium, i.e. oesophageal mucosa, basally located cells exceeded superficial cells in TPA immunoreactivity in contrast to the cytokeratin antibodies which decorated the more superficially placed cell layers. TPA and cytokeratin staining patterns were similar in neoplastic and non-neoplastic gastric, intestinal mucosa, as well as in biliary tract epithelium. Antral and cardial mucoid glands of the stomach as well as gastric carcinomas of the pylorocardial type remained unstained with both types of antibodies. Similar staining with TPA and cytokeratin antibodies was also observed in pancreatic and liver tissue. In this study, hepatocytes were, although weakly, stained by TPA antibodies and an identical staining was found with benign and malignant hepatocellular neoplasms. Ductal and ductular TPA-staining was most conspicuous and so was the immunoreactivity of cholangiocellular carcinomas. A comparison between TPA and cytokeratins was also made by immunoblotting which revealed immunoreactivity of antibodies to TPA with cytokeratin polypeptides of different species (man, mouse) and organs (epidermis, liver), particularly with the cytokeratin component 8 of human liver and the related component A of mouse liver. The significance of this finding is uncertain until the pertinent epitopes have been revealed by monoclonal mapping of the components which exhibit similar molecular weights by SDS polyacrylamide gel electrophoresis.
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  • 6
    ISSN: 1432-2307
    Keywords: Thyroid ; Mixed medullary-papillary carcinoma ; Common stem cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present three thyroid carcinomas displaying medullary and papillary components. In two cases the papillary component was characterized by typical papillae with a fibrovascular core; in one a follicular variant of papillary carcinoma was found. The papillary component was dominant in two and the medullary in one case. One tumour showed clear-cut borders between the two components, the others displayed an intermingled pattern. Both tumour components were seen in lymph node metastases with immunostaining with antibodies to calcitonin, chromogranin A, carcinoembryonic antigen, other neuroendocrine markers and thyroglobulin. At least two of our cases are true mixed carcinomas probably arising from a common stem cell.
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  • 7
    ISSN: 1433-0385
    Keywords: Key words: Schistosoma japonicum ; Rectal carcinoma ; Etiology ; Inflammatory chronic large-bowel disease ; Precancerous condition. ; Schlüsselwörter: Schistosomiasis japonicum ; Rectumcarcinom ; Ätiologie ; chronisch entzündliche Dickdarmerkrankung ; fakultative Präcancerose.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Bei einem 39 jährigen österreichischen Staatsbürger chinesischer Herkunft wurden nach einer Latenzzeit von etwa 20 Jahren nicht nur in dem chirurgisch entfernten Rectumcarcinom, sondern auch in der das Carcinom umgebenden chronisch entzündlich veränderten Rectumschleimhaut mit verschiedenen Schweregraden der Dysplasie und in einem tumorös befallenen benachbarten Lymphknoten, Wurmeier nachgewiesen und daher ein kausaler Zusammenhang angenommen. Während aber der ätiologische Zusammenhang einer chronischen Infektion mit Schistosoma haematobium und dem gehäuften endemischen Auftreten von Blasenkrebs als gesichert gilt, wird bei den intestinalen Formen der chronischen Schistosomiasis eine erhöhte Carcinomkoinzidenz kontrovers beurteilt. Ätiologisch und pathogenetisch ist die Kausalität zwischen Wurmeiablage und späterem Carcinom ähnlich zu sehen wie bei anderen entzündlichen Dickdarmerkrankungen, wo es über die Sequenz chronische Entzündung/schwere Dysplasie zur späteren Carcinomentstehung kommen kann. Neben einer Übersicht über die Parasitologie und Pathologie dieser Trematodenerkrankung wird der ätiologische und pathogenetische Zusammenhang zwischen Rectumcarcinom und Schistosomiasis japonicum anhand entsprechender Literaturstellen hergestellt.
    Notes: Summary. After a latency period of 20 years, in a 39-year-old Austrian citizen of Chinese origin, a surgically removed rectal carcinoma, as well as the neighboring chronic inflammatory rectal mucosa with various degrees of dysplasia and one positive neighboring lymph node, showed helminthiasis in the histopathological examination, convincing us of a link between carcinoma and chronic helminthiasis. Whereas the etiological context between chronic infection by Schistosoma haematobium and endemic frequent urinary bladder carcinoma is considered a matter of fact, whether of not the incidence of intestinal carcinoma is increased in connection with chronic intestinal schistosomiasis is controversial. The etiological and pathogenetic link between helminthiasis and carcinoma should be considered in the same way as for other related inflammatory large-bowel diseases. In the sequence chronic inflammation – severe dysplasia, the formation of carcinoma could possibly occur. Besides a survey of trematodes parasitology and pathology, the link between rectal carcinoma and Schistosomiasis japonicum is pointed out by means of appropriate literature investigations.
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  • 8
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The fate of not mouse adapted influenza virus in the mouse lung was investigated by immunofluorescence methods. The replication of the non adapted virus, which starts just like that of the adapted virus in the alveolar epithelia at the transition from the bronchioles to the alveolar sacs, begins considerably later than after infection with adapted virus. It is at a maximum at about 10 hours p.i. and then subsides. The virus release by the cells is much slower. Neither the bronchioles nor the bronchi or the trachea are involved. Even after 8 days p.i. some isolated alveolar cells show some fluorescence indicating virus release.
    Notes: Zusammenfassung Das Schicksal von nicht mausadaptiertem Influenzavirus in der Mäuselunge wurde unter Anwendung der Immunofluoreszenztechnik untersucht. Die Virusreplikation, die ebenso wie beim adaptierten Virus in den Alveolarepithelzellen im Übergangsbereich vom Bronchulus zum Saccus alveolaris beginnt, setzt wesentlich später ein als nach Infektion mit adaptiertem Virus, erreicht etwa 10 Stunden post infectionem ihr Maximum und klingt dann wieder ab. Die Virusausschleusung aus der Zelle erfolgt wesentlich langsamer. Weder die Bronchiolen noch die Bronchien und die Trachea werden befallen. Noch 8 Tage post infectionem finden sich einzelne infizierte Alveolarepithelzellen, die offenbar Virus abgeben.
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  • 9
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The behaviour of mouse-adapted influenza virus (A2-Asia-Wien 83/M) in the lung of immune mice was investigated after intranasal infection. The replication did not differ appreciably from that in a non-immune animal up to 10 hours post infectionem. Fluorescent material was noted in the bronchi, but this was not accompanied by destruction of bronchial epithelium. From the 8th to 10th hour onward a rapid decrease of the virus replication was seen.
    Notes: Zusammenfassung In der vorliegenden Arbeit wurde das Verhalten von intranasal eingebrachtem mausadaptiertem Grippevirus (A2-Asia-Wien 83/M) in der Lunge immuner Mäuse untersucht. Die Vermehrung unterschied sich bis 10 Stunden post infectionem nur wenig von derjenigen im nicht immunisierten Organismus. Vor allem kam es auch zu einer Bronchialfluoreszenz, die aber nicht mit einer Zerstörung des Bronchialepithels einherging. Ab der 8. bis 10. Stunde post infectionem kam es zu einer raschen Verminderung der Virusreplikation.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Archives of virology 18 (1966), S. 445-451 
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The influence of an intravenous injection of india ink on a subsequent infection with influenza A2 virus (strain Vienna 83/M) in white mice was investigated. The same lung suspension was about five times more effective in treated animals than in the controls. Moreover, the virus titer in the liver of treated animals was significantly higher. In none of the animal groups any antibody could be titrated in the serum until death. There was no difference in interferon content of the liver between india ink treated and control mice.
    Notes: Zusammenfassung In der vorliegenden Arbeit wurde der Einfluß einer intravenösen Tuschegabe auf eine nachfolgende Infektion mit Influenza-A2-Virus (Stamm Wien 83/M) bei weißen Mäusen untersucht. Es erwies sich dabei die gleiche Lungensuspension bei tuschevorbehandelten Tieren als etwa fünfmal wirksamer als bei den unbehandelten Kontrollen. Überdies konnte in der Leber der Tuschetiere ein signifikant höherer Virusgehalt festgestellt werden. Im Serum kam es bis zum Tod der Tiere bei keiner Gruppe zum Auftreten meßbarer Antikörpermengen. Der Interferongehalt der Leber war bei den tuschebelasteten Mäusen und bei den Kontrollen nicht signifikant different.
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