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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  67. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 89. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 44. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20031111-20031116; Berlin; DOC03dguO7-9 /20031111/
    Publication Date: 2003-11-11
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    ISSN: 0303-7207
    Keywords: (Mice, nude) ; Acromegaly ; Autoradiography ; Pituitary neoplasm ; Somatotropin ; Somatotropin-releasing hormone
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Results of neonatal screening for phenylketonuria (PKU) suggest a west-east gradient of PKU gene frequency in central Europe. In order to test the hypothesis that the unexpectedly high prevalence of PKU in northwestern Germany (northern region of the FRG) is due to the migration of Germans from eastern regions of prewar Germany in the decade after World War II. grandparental origin was determined in a group of 87 pediatric PKU patients and in a control group of 210 children. Grandparents of east German origin were significantly more frequent among the PKU patients. The observed frequency distribution of grandparental subgroups was described by a theoretical distribution in order to obtain a likely set of values for the ratio between the frequency of the PKU gene in the autochthonous populations of prewar northeastern and northwestern Germany. The most likely value for the PKU gene frequency ratio was 1.37, which indicates that the prevalence for PKU in prewar northeastern Germany was almost twice as high as in the autochthonous population of the northwest.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1246
    Keywords: Temperature rhythm ; Watchkeeping systems ; Ships ; Cosinor analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oral temperature data were collected from 12 members of the crew of an oil tanker at sea. Most of the personnel examined were engaged on watchkeeping duties on a ‘4 on, 8 off’ fixed-hours system; the remainder included 3 “day-workers”. The study commenced after the subjects had been following their particular work schedules continuously for several weeks, thus providing good opportunity for adaptation to them. Observations were made at 4-hourly intervals during waking hours, over a period ranging from 8 to 13 days in individual cases. The form of the mean curves produced by averaging the readings over all days indicated that a reasonable degree of adjustment of the temperature rhythm to the different sleep/wake routines imposed by the work system had occurred. Estimates of rhythm phase and amplitude obtained by “single cosinor” time series analyses of the sequential data supported this impression. However, further investigations are needed to substantiate these findings, and also to determine how long it takes for the rhythm adjustment process to reach completion in inexperienced workers.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1076
    Keywords: Germinoma ; Teratoma ; Pineocytoma ; Pinealoblastoma ; Astrocytoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In Germany, the relative frequency of pineal region tumours seems to be much higher than hitherto assumed. At the University Hospital Hamburg, from 1980–1985 17 children with pineal region tumours were encountered amongst 102 children with CNS tumours. Two-cell-type germinoma is the most frequent pineal region tumour. Cerebrospinal fluid cytology is highly successful in identifying this germ cell tumour. Surgical removal has become a reasonably safe procedure in the treatment of pineal region tumours and was successful in all 10 cases so treated. In addition, our patients with two-cell-type germinomas received craniospinal axis radiation. All children, treated by both surgical removal and craniospinal exis radiation are so far relapse-free and are functioning on a pretreatment level.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1041
    Keywords: Trospium chloride ; Gastrointestinal motor function ; gall bladder contraction ; gastric emptying ; gastrooesophageal reflux ; orocaecal transit time ; Oesophageal pH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The aim of this double-blind, placebo-controlled, cross-over study was to investigate the effect of trospium chloride on gall bladder contraction, gastric emptying of a liquid meal, gastrooesophageal reflux, and orocaecal transit time in healthy subjects. Gall bladder contraction was examined by ultrasonography before and after stimulation with two raw eggs. Gastric emptying was evaluated by an intubation technique and by sonography. To determine gastrooesophageal reflux and orocaecal transit time, 24-hour pH metry and a hydrogen breath test were used. The gall bladder ejection fractions were significantly lower after oral treatment with both 4×10 mg and 4×20 mg trospium compared to placebo, but no difference was seen between the two doses of drug. Gastric emptying of a liquid meal was significantly delayed after intake of 4×15 mg trospium, whilst the time course of the intragastric volume determined by ultrasound did not differ from that after placebo, suggesting an antisecretory effect of trospium on gastric secretion. The fractional time of oesophageal pH〈4 as a percentage of the entire 24-hour investigation period was significantly increased by treatment with trospium 3×15 mg per day. The orocaecal transit time of 10 g lactulose was significantly prolonged. Provided that the observed effects on gall bladder contraction, gastric emptying, and orocaecal transit time are reproduced in disease states, trospium should be regarded as a potentially useful antispasmodic agent.
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  • 8
    ISSN: 1432-1076
    Keywords: Intracranial germ-cell tumours ; Childhood ; Residuals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There is only sparse information about the development of children after successful treatment for intracranial germ-cell tumours. Between January 1981 and June 1992, 26 children with intracranial germ-cell tumours were treated in the University Hospital Hamburg-Eppendorf. We report on treatment results, long standing residuals and the “quality of life” of these patients. The long-term event-free survival was 88% for the germinomas and 43% for the malignant teratomas. Of the patients 58% had no relevant functional neurological deficits and 37% had mild impairment. Only 1 patient with metastatic disease was severely handicapped. Six patients showed neuro-endocrine dysfunction. All of them had suprasellar/hypothalamic lesions and all received successful substitution therapy. As to neuropsychological functions, 53% of the patients had no or only mild disturbances. The most affected function was speed of information processing. Of the children 69% were able to proceed with their education at the same level as before therapy. The overall self-assessment revealed good results in 75% of the patients. Conclusion After surgical removal and radiation therapy long-term survival of intracranial germinomas amounts to 88%. Despite craniospinal axis radiation severe residuals are rare and a good quality of life is common. In malignant teratomas treatment regimens including chemotherapy are much less successful.
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  • 9
    ISSN: 1433-8491
    Keywords: Haemangioblastoma ; Lindau tumor-von HippelLindau disease ; Cerebellar function ; EOG ; Hämangioblastom ; Lindau ; Tumor ; von Hippel Lindau'sche Krankheit ; Kleinhirnfunktion ; EOG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 46 Patienten mit einem Hämagio-blastom des Zentralnervensystems (Neurologische Universitäts-Klinik Hamburg-Eppendorf,1950–1980) fanden sich überwiegend (n = 40) Kleinhirnangioblastome (Lindau-Tumoren), von denen 21 im Jahre 1983 nachuntersucht werden. Kopfschmerz als Initialsymptom fand sich etwa dreimal so häufig wie Schwindel, sensomotorische Ausfälle and cerebelläre Gangstörung (43% zu 10–15%). Hirndrucksymptome waren häufiger diagnostisch wegweisend als Schwindel und Gangstörung. Seit der Einführung des CCT erlaubte die zusammengefaßte Beurteilung von CCT und Vertebralisangiographie immer die zutreffende preoperative Diagnose. Die geringe Gesamtoperationsmortalität von 13,5% konnte im letzten Jahrzehnt auf 0% gesenkt werden. Bei einer Gesamtrezidivhäufigkeit von 8,7% fand sich bei 21 Nachuntersuchungen einschließlich CCT and EOG kein Rezidiv. Nicht so haufig wie bisher allgemein angenommen, kamen in unserem Krankengut vor: Familiäre Häufung (0%), multiple Tumorlokalisationen and gleichzeitiges Vorkommen mit Angiomatosis retinae (0%), Polyglobulie (10,8%). Psychische Veräenderungen (45,6%) ließen sich stets nur bei gleichzeitig bestehender Hirndrucksymptomatik nachweisen. Die Ergebnisse der Nachuntersuchungen zeigen, daß Reststörungen bzw. mögliche Rezidive genauer and früher als durch die klinische Untersuchung allein mit einer zusammengefaßten Beurteilung von CCT and EOG erkannt and verlaufsmäßig objektiviert werden können.
    Notes: Summary In a survey of 46 patients with haemagioblastoma of the CNS (Neurology Dept. University Hamburg, 1950–1980) most (n = 40) were found to have angioblastomas of the cerebellum (Lindau tumors). Of these patients 21 were re-examined in 1983. Headache was the most frequent initial symptom (43%), and within this group one-third (10%–15%) had dizziness, sensorymotor deficits and cerebellar gait disturbances. Signs of elevated intracranial pressure much more often led to the correct diagnosis than dizziness or dystaxia. After the introduction of CCT to the diagnostic procedure the combined evaluation of angiography of the vertebral arteries and CCT always permitted the correct diagnosis. The low neurosurgical mortality rate (13.5%) has decreased to 0% within the last decade. No relapses were found in 21 re-examinations including CCT and EOG compared to a frequency of 9.7% in all 46 cases. Significantly less often than expected from other data we found: signs of possible hereditary influence (0%), multiple tumor localization combined with angiomatosis retinae (0%), polyglobulia (10.8%). Psychopathologically relevant signs (45.6%) were, in all cases, combined with signs of increased intracranial pressure. The results of our re-examination demonstrate that late postoperative deficits as well as possible relapses are earlier and more precisely evaluated by the combined use of clinical examination, CCT and EOG.
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  • 10
    ISSN: 1433-8580
    Keywords: Bubble-flow-meter ; Blood flow measurement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The construction of a simple bubble-flow-meter is described. The instrument has the following features: 1. automatic bubble injection, 2. precise measurement of the bubble passage time by a digital counter, 3. quasicontinuous registration of the flow rate, 4. alternative run with clear fluid (water) and coloured fluid (blood), 5. low volume, 6. closed measuring system for measurements in low and high pressure systems.
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