Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-1041
    Keywords: Key words Buckwheat herb ; Oedema protection; chronic venous insufficiency ; Fagopyrum esculentum ; microcirculation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objectives: The efficacy of a buckwheat herb tea was determined in patients with chronic venous insufficiency (CVI) in a single-centre, randomised, double-blind, placebo-controlled clinical trial. Methods: Sixty-seven male and female patients (22–74 years) with CVI were randomly divided into two groups after a 2-week run-in period. They received either buckwheat herb tea (Fagopyrum esculentum) or a placebo tea for a period of 3 months. The main outcome measure was the lower leg volume determined by ultrasound. Subjective symptoms were assessed by a clinical symptom score system. The femoral vein diameters were measured by B-scan sonography. In a subgroup of patients capillary permeability was determined by cutaneous fluorescence angiography. Results: Although the mean partial leg volume did not change in the treatment group (from 2041 to 2073 ml), it increased in the placebo group by 110 ml (from 1972 to 2082 ml) according to intent to treat. The difference between the groups was significant. The subjective clinical symptoms were significantly reduced in both groups. The mean diameters of the femoral veins were reduced and capillary permeability was improved, but neither change was statistically significant. No drug-related adverse effects were observed. Conclusion: CVI is a very placebo-sensitive condition. The treatment with buckwheat herb tea is safe and could have a favourable influence on patients with CVI such that further oedema development is prevented.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-2129
    Keywords: Schlüsselwörter Trigeminusneuralgie ; CSF ; Neurotransmitter ; Substanz P ; Somatostatin ; Key words Trigeminal neuralgia ; Neurotransmitters ; CSF ; Substance P ; Somatostatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The etiology of trigeminal neuralgia is unknown, but both peripheral and central causes have been suggested. To investigate the role of central neurochemical mechanisms we measured epinephrine, norepinephrine and their breakdown product, vanilly mandelic acid (VMA), in the cerebrospinal fluid (CSF) of 16 patients (53.3 ± 8.3 years) suffering from trigeminal neuralgia. As markers for the dopaminergic system, we determined CSF levels of dopamine and its metabolite homovanillic acid (HVA). As a marker for the serotonergic system, we measured CSF levels of serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA). In addition, levels of the neuropeptides substance P and somatostatin were determined. The concentration of norepinephrine (P 〈 0.01), VMA (P 〈 0.05) and HVA (P 〈 0.05) were significantly decreased in patients with trigeminal neuralgia and correlated with the duration of the disease and depression scores. 5-HIAA was also significantly decreased (P 〈 0.05) compared to control patients. Whereas substance P was significantly elevated (P 〈 0.05), somatostatin was significantly decreased (P 〈 0.05). Various correlations between the classical neurotransmitters and the neuropeptides could be established. We hypothesize than the sum of complex neurochemical changes plays a role in the etiology of trigeminal neuralgia, which can be separated in local and more central proceedings. The increase in substance P, a major nociceptive neuromodulator, supports the concept of a local neurogenic inflammation, possibly located in the trigeminovascular system. Depending on the duration of the disease and depression, the loss of serotonergic, dopaminergic and noradrenergic innervation seems to reflect more central changes, possibly due to alterations in their antinociceptive descending pathways.
    Notes: Zusammenfassung Bei der Trigeminusneuralgie werden periphere und zentrale Entstehungsmechanismen diskutiert. Daher wurden bei 16 Patienten (53,3 ± 8,3 Jahre) mit einer idiopathischen Trigeminusneuralgie in der Zerebrospinalflüssigkeit (CSF) die Neuropeptide Substanz P und Somatostatin, die Neurotransmitter Noradrenalin und Adrenalin sowie die Metaboliten Homovanillinmandelsäure (HVA), Vanillinmandelsäure (VMA) und 5-Hydroxyindoleessigsäure (5-HIAA) bestimmt. Während die Substanz P in der CSF signifikant (p 〈 0,01) erhöht gefunden wurde, war das Somatostatin gegenüber den Kontrollpersonen signifikant erniedrigt (p 〈 0,05). Noradrenalin (p 〈 0,01), 5-HIAA (p 〈 0,01), HVA (p 〈 0,05) und VMA (p 〈 0,05) waren signifikant erniedrigt. Während die Erhöhung der Substanz P einen Hinweis auf eine lokal beschränkte neurogene Entzündung im trigemino-vaskulären System geben könnte, spricht die Reduktion monoaminerger Transmitter für eine zentral gestörte Schmerzmodulation. Diese scheint mit zunehmender Krankheitsdauer und begleitender Depression stärker zu werden. Die zahlreichen Korrelationen der Neuromediatoren untereinander, insbesondere auch zwischen den Neuropeptiden und den klassischen Neurotransmittern, sprechen für komplexe neurochemische Interaktionen im Rahmen der Schmerzentstehung.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Applied mathematics & optimization 30 (1994), S. 113-126 
    ISSN: 1432-0606
    Keywords: Nonconvex variational problems ; Relaxation ; Optimal control ; 49J27 ; 35B25 ; 65N30
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract An optimal control problem for a multivalued system governed by a nonconvex variational problem, involving a regularization parameter ɛ〉0, is proposed and studied. The solution to the variational problem exhibits typically rapid oscillations (a so-called fine structure) corresponding to a multiphase state of the material. We want to control only this fine structure. Existence of an optimal control is proved. Its convergence with ɛ→0 is studied by means of an optimal control problem for a relaxed variational problem involving (suitably generalized) Young measures. The uniqueness of the solution to the relaxed variational problem, which is nontrivial but is very important in the context of optimal control, is studied in special cases. A finite-element approximation is proposed.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 96 (1995), S. 409-416 
    ISSN: 1434-6036
    Keywords: 05.40 ; 05.70L ; 02.50
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We investigate in some detail the relaxation process in self similar hierarchies. We find that the process can be divided in four different time regimes. After an initial phase in which the connectivity of the hierarchy determines the relaxation, the system enters a kind of stationary state, which can be accurately described by a simple analytical sink-picture. At longer times the behavior of the process is correctly described by the idea of quasiequilibrium. In this regime, propagators decay with power-laws. Finally, the global equilibrium state is reached, and the evolution stops.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 60 (1985), S. 401-414 
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The eigenvalues of the master equation describing the motion on a nested hierarchy ofd-dimensional intervals with selfsimilar scaling of spatial extension as well as of the level dependent transition rates are derived. Based on this spectrum the diffusion behaviour is obtained, which is anomalous, either exponential or obeying a power law with various exponents. Emphasis is put on the insight into the mechanism of the anomalous diffusion, in particular the geometrical structure of the decay rate spectrum.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We consider a model forN electrons confined to the surface of a sphere in a strong radial magnetic field. The electron-electron interaction is modelled as a simple hardcore like repulsion. Numerical calculations have been carried out for up toN=6, neglecting contributions from higher Landau levels. Spectral properties of low-lying states are discussed within the quasihole-quasiparticle picture.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1420-9071
    Keywords: Crickets ; corpus allatum activity ; juvenile hormone III ; temperature ; reproduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the Mediterranean field cricket,Gryllus bimaculatus, reproduction is controlled by temperature and the corpus allatum (CA) hormone JH III. In CA of females reared at 24°∶12°C(16∶8 h) (high reproduction rate) a first peak in JH III synthesis is reached about 4 days earlier than in those of 20°C females (low reproduction rate). Furthermore, in 20°C animals CA activity is low during the entire oviposition period, whereas at 24°∶12°C high CA activity is found during this period of adult life. The results indicate a stimulation of CA activity and reproduction by thermoperiods around a constant low temperature.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1432-136X
    Keywords: C-20 hydroxylation ; Ecdysone metabolism ; Midgut ; Microsomes ; Steroid hydroxylase ; Gryllus bimaculatus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Ecdysone 20-monooxygenase, the enzyme system which converts ecdysone into 20-hydroxyecdysone, was characterized in the midgut of 4-day-old female adult Gryllus bimaculatus using an in vitro radioassay. Differential centrifugation and sucrose gradient centrifugation revealed that ecdysone 20-monooxygenase activity is associated with the microsomal fractions. The 20-monooxygenase was found to be most active in potassium phosphate buffer, pH 7.8, at an osmolarity of 100 mOsm and at 39 °C assay temperature. The conversion of ecdysone into 20-hydroxyecdysone was linear over an incubation period of 12 min and with respect to a protein concentration of 3 mg·ml−1. K+ and Na+ (10−3–10−1 M), Ca2+ (2.3 mM), and EDTA (1–5 mM) did not affect monooxygenase activity, whereas Mg2+ (2.3–10 mM) slightly inhibited enzyme activity. The enzyme complex has an apparent Km for ecdysone of 3.7·10−7 M and is competitively inhibited by its product, 20-hydroxyecdysone, with an apparent Ki of 4·10−6 M. The cytochrome P-450 nature of the steroid hydroxylase was shown by its obligate requirement for NADPH and its inhibition by carbon monoxide, metyrapone, and p-chloromercuribenzoate, but not by cyanide. The insect systemic growth disruptor, azadirachtin, was found to inhibit ecdysone 20-monooxygenase activity with a I50 of 8·10−4 M. From the CO-difference spectrum, a cytochrome P-450 content of 285 pmol·mg protein−1 was calculated for midgut microsomes of 4-day-old females.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1432-136X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary 1. During anaerobic exposure ofTubifex, lactate and alanine increase only within the first 24 h, while concentrations of succinate, propionate and also acetate continually increase under prevailing anaerobic conditions. Enzymes involved in anaerobic energy metabolism were isolated, and the effects of various metabolites and inorganic compounds on their catalytic properties studied. 2. The specific activities of the cytosolic enzymes LDH, PK, MDH, and PEPCK, and of mitochondrial malic enzyme and MDH are high. 3. Under conditions of high HCO 3 − (HCO 3 − +CO2 system), PEPCK is maximally active while PK is inhibited. 4. The catalytic properties of mitochondrial malic enzyme indicate that in vivo this enzyme operates in the direction of malate decarboxylation. 5. The cytosolic oxidoreductases LDH and MDH were examined with regard to the maintenance of redox state. Function of MDH is only subject to substrate availability, while the enzyme-substrate affinity of LDH might be affected by pH to a limited extent. 6. The data support the conclusion that total CO2, fructose-1,6-diphosphate concentration, the adenylate energy charge, and-only to a limited extent-the intracellular pH are regulatory signals which govern PEP metabolism inTubifex.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...