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  • Articles  (37)
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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  15. Deutscher Kongress für Versorgungsforschung; 20161005-20161007; Berlin; DOCP130 /20160928/
    Publication Date: 2016-09-28
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  17. Deutscher Kongress für Versorgungsforschung (DKVF); 20181010-20181012; Berlin; DOC18dkvf205 /20181012/
    Publication Date: 2018-10-13
    Keywords: ddc: 610
    Language: German
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  17. Deutscher Kongress für Versorgungsforschung (DKVF); 20181010-20181012; Berlin; DOC18dkvf150 /20181012/
    Publication Date: 2018-10-13
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
    ISSN: 1432-1041
    Keywords: Methylprednisolone aceponate ; New topical glucocorticosteroid ; efficacy ; vasoconstrictor assay ; Poison Ivy Test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Topical glucocorticosteroids are useful in the treatment of various skin diseases. Although many corticosteroids are available today, there is still a need for highly potent compounds with minimal adverse effects. Methylprednisolone aceponate (MPA) has recently been synthesized. Its activity has been evaluated using the vasoconstrictor assay and the poison ivy test (rhus dermatitis) in 19/20 healthy volunteers of either sex. Comparable blanching was found with MPA in a cream vehicle, in an ointment and a fatty ointment. Vasoconstriction and suppression of experimentallyinduced poison ivy contact dermatitis were dose-dependent in the concentration range 0.01% to 0.5% MPA. Concentrations of MPA of at least 0.05% were significantly active. Following the highest dose, blanching was close to the maximum which can be obtained. This finding, and the improvement of rhus dermatitis, suggest that MPA belongs to the highly potent local glucocorticosteroids.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1420-9136
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Summary A method for calculating the complex ionospheric reflection coefficients at vlf using sferic waveforms is presented. The mathematical analysis was carried out for a number of different waveforms to illustrate the method. Reflection coefficients determined from sferics observations were compared with those calculated using an ionospheric model. In most cases, the agreement with theory is fairly good although in some cases, reflection coefficients exceeding unity were obtained. The discrepancies are believed to result from horizontally polarized flashes rather than limitations in the ionospheric model.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) caused a rapid and long-lasting reduction of both 3,4-dihydroxyphenylalanine (dopamine, DA) and noradrenaline (NA) in mouse brain, as observed histo- and neurochemically. The depleting effects were more pronounced after repeated MPTP administration and the most marked reductions were observed after 2 × 50 mg MPTP/kg s.c., when DA in striatum and NA in frontal cortex were reduced by 〉 90% 1 week after MPTP. Mice with such catecholamine depletions were markedly sedated and almost completely immobilized. The behavioural syndrome after MPTP resembled that seen after reserpine, a monoamine-depleting drug. MPTP also caused a long-lasting reduction of catecholamine uptake in striatal DA and cortical NA nerve terminals and reduced tyrosine hydroxylase activity in these regions. There was no evidence that MPTP caused any marked DA and NA cell body death. MPTP given acutely transiently elevated serotonin levels. The results are compatible with a neurotoxic action of MPTP on both DA and NA nerve terminals. The nigro-striatal DA and the locus coeruleus NA neurone systems appeared to be most susceptible. Synthesis and utilization of residual striatal DA and cortical NA were increased, as often observed in partially denervated monoamine-innervated brain regions. Both DA and NA showed a gradual recovery, which took months to become complete and may have been related to a regrowth of catecholamine nerve terminals.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Constructive approximation 11 (1995), S. 321-329 
    ISSN: 1432-0940
    Keywords: 30B70 ; 40A15 ; Continued fractions ; Convergence regions ; Separation results
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract We prove that the oval convergence theorem for continued fractionsK(a n /1) follows from the uniform parabola theorem and from the uniform limacon theorem. Thus we are able to deduce that the ovals are uniform convergence regions and give estimates for the speed of convergence. Certain separation properties of the ovals are also established.
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  • 8
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The paramyxovirus SV5 was originally detected in monkey tissues6 and has never been associated with any human disease. It has been isolated from a number of human sources7'8, however, including the bone marrows of multiple sclerosis (MS) patients9'10. Subsequent studies, using monoclonal ...
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  • 9
    ISSN: 1615-6102
    Keywords: Fungus ; Meiosis ; Physoderma ; Sporangium germination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The structural and developmental characteristics of the resting sporangium in uniflagellate phycomycetes, together with the type of zoospore, are of high taxonomic value. Among these fungi, however, only a few electron microscopic investigations have been published on this topic, mainly due to technical problems. In the present study ofPhysoderma maydis (Blastocladiales) these problems were overcome as the resting sporangia in this species are formed synchronously, in large numbers, the germination is readily induced and the impermeability of the resting sporangium wall can be circumvented by shaking the prefixed sporangia with glass beads. The germination of the resting sporangia ofP. maydis is described by correlative light and electron microscopic studies and discussed in relation to related investigations on sporogenesis: The germination process starts by a breakdown of large electron-dense accretions found in the resting stage. Simultaneously, the peripheral location of the lipid bodies is lost. The large operculum is pushed open by a protrusion of the inner sporangial wall; an additional wall layer is formed during this process. Synaptonemal complexes are found in the nuclei at this stage, as are nuclear division figures which suggests anEuallomyces type of life cycle for this fungus. Cleavage vesicles, formed from dictyosomes or endoplasmic reticulum, ultimately separate the sporangial content into meiospores. The sequential assembly of organelles into the side body complex is described. Sequestering of the ribosomes into a nuclear cap is interpreted as taking place immediately prior to zoospore discharge.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1615-6102
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The zoospore and meiospore of the aquatic phycomyceteCatenaria anguillulae (Phycomycetes, Blastocladiales, Catenariaceae) have a nuclear cap enclosing the cellular ribosomes within a double membrane, and a side body complex which is very similar to that observed in zoospores ofBlastocladiella andCoelomomyces and is structurally related to the side body complex observed in spores ofAllomyces. The structural organization of the side body complex and striated rootlet is analyzed from serial sections. The meiospore also contains an array of flattened cisternae which are in direct contact with, and appear to be derived from, the outer nuclear membrane and the backing membrane of the side body complex. The structural organization of the zoospore and meiospore ofC. anguillulae is compared to and contrasted with the structural organization observed in spores of members of theChytridiales, Blastocladiales, Monoblepharidales, andHarpochytriales. It is concluded that the structural organization of the spores of theBlastocladiales, Monoblepharidales, andHarpochytriales is similar, and affinities in spore organization can be found in some members of theChytridiales.
    Type of Medium: Electronic Resource
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