Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Articles  (990)
Collection
Language
  • 1
    ISSN: 0896-8446
    Keywords: critical loci ; lattice theory ; multiphase behaviors ; supercritical fluid mixtures
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study was undertaken to investigate the immunohistochemical characterization of different subpopulations of macrophages and dendritic cells (DCs) of the spleen, thymus, tongue and heart in cyclophosphamide (CY)-induced immunosuppressed rat. After CY treatment, remarkably, ED1+, ED2+ and ED3+ macrophage subpopulations, in general, exhibited signs of cellular activation such as an increase in number and size of cell, and an upregulation of the ED1, ED2 and ED3 reactive surface molecule expression in all the organs studied, except for some macrophage subpopulations including ED1+ macrophages in the non-lymphoid tissues. Subpopulations of DCs showed a differential sensitivity to CY. Lymphoid DCs were more sensitive to CY than non-lymphoid interstitial DCs. CY induced a conspicuous upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in the vascular endothelial cells, splenic marginal zone and thymic cortex. In this study, we demonstrated the in vivo effects of CY treatment on subpopulations of macrophages and DCs as well as on ICAM-1 expression in the rat spleen, thymus, tongue and heart. Moreover, our results shed more light on the activation effects of CY on certain subpopulations of macrophages, on the differential sensitivity of DCs to CY between the immature and mature ones, on the functional role of different subpopulations of macrophages, and on the significance of upregulated ICAM-1 expression in the splenic marginal zone and thymic cortex after CY treatment.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Shubnikov–de Haas (SdH) and van der Pauw Hall effect measurements on In0.52Al0.48As/InxGa1−xAs coupled double quantum wells grown by metalorganic chemical vapor deposition have been carried out to investigate the magnetotransport properties of an electron gas and to determine the subband energies and wave functions in the coupled quantum wells. Transmission electron microscopy measurements showed that In0.8Ga0.2As and In0.53Ga0.47As quantum wells were separated by an In0.25Ga0.75As potential barrier in an active region. The SdH measurements at 1.5 K demonstrated clearly the existence of a quasi-two-dimensional electron gas in the quantum wells. The fast Fourier transformation results for the SdH data clearly indicate the occupation of three subbands in the In0.52Al0.48As/InxGa1−xAs coupled quantum wells. Electron subband energies and wave functions in the quantum wells were calculated by a self-consistent method taking into account exchange-correlation effects. The first and second excited subband wave functions in the asymmetric quantum well are strongly coupled over both In0.8Ga0.2As and In0.53Ga0.47As wells. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract Precision etch-depth control is realized by a chemically assisted ion-beam etching system incorporated within situ laser reflectometry. By counting the number of interference fringes, etch-depth control better than a quarter-wave thickness is easily obtained. Optimized etching conditions for highly anisotropic etching of bulk GaAs and AlGaAs/GaAs distributed Bragg reflectors are obtained. With the ability to etch-stop just below the active region by thein situ monitoring, InGaAs vertical-cavity surface-emitting lasers with CW threshold current density as low as 380 A cm-2 with output power 〉11 mW are fabricated. Spatial uniformity is 5% over a 1-cm2 sample, which corresponds to one pair over 20 pairs of quarter-wave stacks of AlGaAs/GaAs distributed Bragg reflectors.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: We report important factors affecting the dielectric properties of CaCu3Ti4O12 (CCTO)polycrystalline ceramics prepared by the conventional solid-state ceramic process. The relativedielectric constants (εr) up to several thousands (~ 3,000 at 1 kHz) were gradually increased withincreasing the sintered density of samples in the case that no exaggerated grain growth occurred. Anabrupt increase in εr values were, however, accompanied by the formation of abnormally grown largegrains, and thus with increasing the population of abnormally grown grains, which could be achievedby a prolonged sintering at 1060°C, the εr values were remarkably increased from several thousands to~105. Optimally processed CCTO sample exhibited a very high εr of ~ 90,000 at 1 kHz
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1573-6776
    Keywords: enzyme ; extraction ; Horseradish peroxidase ; organic solvent ; reactivation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A novel extraction method was developed aiming at increasing the stability of enzymes in organic solvent media. Horseradish peroxidase (HRP), inactivated in a tetrahydrofuran (THF)/water (1:1, v/v), regained and maintained its activity when HRP was extracted by adding a THF/benzene mixture to the original solution. However, the HRP activity was drastically lowered in the enzyme-free blank solution that had been formed by employing the same extraction procedure. As a result, the reactivation after the extraction is believed to depend on enzyme history, and might be arisen from an irreversible structural change of the enzyme.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Conditions for the production of intracellular fructosyl transferase fromA. pullulans were investigated. Sucrose was an excellent carbon source, and there was a tendency for the enzyme production to be increased as sucrose concentration was increased. Both 0.5% phosphate and 2% sodium nitrate had positive effects on enzyme production. It was possible to increase the intracellular enzyme production up to 140% by increasing the concentration of magnesium sulfate from 0.05 % to 0.2%.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1572-9567
    Keywords: lattice-hole theory ; polymer solutions ; specific volume ; vapor–liquid equilibria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A generalized group-contribution (GC) scheme with an equation of state (EOS) presented previously by the present authors was extended to the prediction of specific volumes of pure polymers and vapor–liquid equilibria of polymer solutions. The GC-EOS requires only two parameters, representing group size and interaction between groups. A unique feature of the approach is that a single set of group information can be applied to predict both the configurational properties of pure polymers and mixtures in general. The approach was illustratively applied to the prediction of the density of pure polymers, vapor pressures of organic solvents, and phase equilibria of their polymer solutions.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Shubnikov–de Haas (SdH), Van der Pauw Hall-effect, and cyclotron resonance measurements on InxGa1−xAs/In0.52Al0.48As asymmetric step quantum wells were carried out to investigate the electrical properties of a free electron gas and to determine the effective mass of the electron gas, the subband energies, and the wave functions in the InxGa1−xAs quantum wells. The SdH measurements at 1.5 K demonstrated clearly the existence of a quasi-two-dimensional electron gas in the InxGa1−xAs quantum wells, and the fast Fourier transformation results for the SdH data indicated clearly the occupation by that gas of two subbands in the quantum wells. The electronic effective masses determined from the slopes of the main peak absorption energies as a function of the magnetic field were 0.0477 and 0.053 me for the first excited and the ground subbands, respectively. The electronic subband energies and the wave functions in the InxGa1−xAs/In0.52Al0.48As step quantum wells were calculated by a self-consistent method taking into account exchange-correlation effects together with the strain and nonparabolicity effects. The results of the cyclotron resonance measurements qualitatively satisfied the nonparabolicity effects of the step quantum well. These results can help improve understanding for the application of InxGa1−xAs/In0.52Al0.48As step quantum wells in optoelectronic devices. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2018-02-02
    Description: Neuroinflammation-associated release of glutamate from activated microglia has been implicated in the progression of neurodegenerative diseases. However, the regulatory mechanisms underlying this glutamate release are poorly understood. Here, we show that peroxisome proliferator-activated receptor delta (PPARδ) modulates neurotoxicity by inhibiting glutamate release in lipopolysaccharide (LPS)-activated BV-2 microglial cells. Activation of PPARδ by GW501516, a specific PPARδ agonist, inhibited glutamate release in BV-2 cells. This effect of GW501516 was significantly blocked by shRNA-mediated knockdown of PPARδ and by treatment with GSK0660, a specific PPARδ antagonist, indicating that PPARδ is associated with blockade of glutamate release. Additionally, GW501516-activated PPARδ suppressed generation of reactive oxygen species and expression of gp91phox, a functional subunit of NADPH oxidase 2, in BV-2 cells stimulated with LPS. The inhibitory effect of GW501516 on gp91phox expression and glutamate release was further potentiated in the presence of AG490, a specific inhibitor of janus kinase 2 (JAK2), leading to the inhibition of signal transducer and activator of transcription 1 (STAT1). By contrast, GW501516 upregulated the expression of suppressor of cytokine signaling 1 (SOCS1), an endogenous inhibitor of JAK2. Furthermore, neurotoxicity induced by conditioned media from LPS-stimulated BV-2 cells was significantly reduced when conditioned media from BV-2 cells treated with both LPS and GW501516 were used. These results indicate that PPARδ attenuates LPS-triggered neuroinflammation by enhancing SOCS1-mediated inhibition of JAK2/STAT1 signaling, thereby inhibiting neurotoxicity associated with glutamate release. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley-Blackwell
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...