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  • DKFZ Publication Database  (2)
  • ACTINIC KERATOSES  (2)
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  • DKFZ Publication Database  (2)
  • 1
    Keywords: CANCER ; tumor ; BLOOD ; carcinoma ; CELL ; human ; DIAGNOSIS ; COHORT ; EPIDEMIOLOGY ; RISK ; TIME ; INFECTION ; ANTIGEN ; antibodies ; antibody ; virus ; NO ; DIFFERENCE ; PLASMA ; COMPONENT ; VIRUS-LIKE PARTICLES ; HPV ; case-control studies ; squamous cell carcinoma ; INDIVIDUALS ; L1 ; INFECTIONS ; PREVALENCE ; European Prospective Investigation into Cancer and Nutrition ; nutrition ; SKIN-CANCER ; glutathione-S-transferase ; CELL CARCINOMA ; ONCOLOGY ; case control study ; case-control study ; PATTERN ; EPIDERMODYSPLASIA-VERRUCIFORMIS ; prospective studies ; case control studies ; ACTINIC KERATOSES ; USA ; prospective ; prospective study ; UNIT ; SQUAMOUS-CELL ; serology ; HUMAN PAPILLOMAVIRUSES ; SEROPREVALENCE ; case control ; cutaneous squamous cell carcinoma (SCC) ; HPV types ; human papillomavirus (HPV) ; ORGAN-TRANSPLANTATION ; prospective case-control
    Abstract: In a prospective pilot study nested in the EPIC-Oxford cohort, we examined the seroprevalence of antibodies against the L1 antigen of 38 human papilloma virus (HPV) types among 39 cases of cutaneous squamous cell carcinoma (SCC) for whom plasma was collected prior to diagnosis (incident) and 80 controls. Fifteen cases having already developed SCC at blood collection (prevalent) were also tested. There were no statistically significant differences in the seroprevalence of antibodies against any of the HPV types examined between incident cases and controls, nor was there a difference in the seroprevalence of multiple infections. However, consistent with results from published case-control studies, the seroprevalence of many beta-HPV types was higher among prevalent cases than among either incident cases or controls. For example the seroprevalence of antibodies against HPV-8 was 20% (16/80) in controls, 23% (9/39) among incident cases and 40% (6115) among prevalent cases. Among the incident cases only, the seroprevalence was 16% (5/32) among those for whom blood was collected 18+ months prior to diagnosis, but 57% (4/7) among those for whom diagnosis was within 18 months of blood collection, a pattern seen for many of the HPV types. This might suggest that if HPV is involved in the aetiology of SCC, the process occurs close to the time of diagnosis, or that the antibody response observed in people with SCC is a consequence of tumor formation. Further and larger prospective studies are needed to clarify the role of HPV in the aetiology of cutaneous SCC. (C) 2007 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 17565742
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  • 2
    Keywords: CANCER ; carcinoma ; CELL ; human ; COMMON ; COHORT ; EPIDEMIOLOGY ; HISTORY ; POPULATION ; RISK ; PROTEINS ; TIME ; DNA ; INFECTION ; RISK-FACTORS ; ANTIGEN ; SKIN ; papillomavirus ; ASSOCIATION ; SUSCEPTIBILITY ; antibodies ; antibody ; AGE ; WOMEN ; MEN ; RISK FACTOR ; human papillomavirus ; VIRUS-LIKE PARTICLES ; HPV ; HUMAN-PAPILLOMAVIRUS ; POPULATIONS ; case-control studies ; squamous cell carcinoma ; L1 ; PREVALENCE ; glutathione-S-transferase ; SERUM ; CELL CARCINOMA ; case control study ; case-control study ; RECIPIENTS ; HPV 16 ; TECHNOLOGY ; ACTINIC KERATOSES ; NONMELANOMA SKIN-CANCER ; HISTOLOGY ; USA ; UNIT ; RISK-FACTOR ; SQUAMOUS-CELL ; IMMUNOCOMPETENT INDIVIDUALS ; serology ; SEROPREVALENCE ; cutaneous squamous cell carcinoma (SCC) ; HPV types ; human papillomavirus (HPV) ; Genital warts ; CONFIDENCE ; organ transplant recipients ; SCC
    Abstract: A case-control study was conducted in 140 people with histology proven cutaneous squamous cell carcinoma (SCC) and 454 controls, nested within 2 cohorts of organ transplant recipients (OTR) recruited in London and Oxford between 2002 and 2006. All participants had a skin examination, completed a questionnaire and had serum tested for antibodies against the L1 antigen of 34 HPV types using Luminex technology. SCC was more common in men than women (odds ratio [OR] = 1.7, 95% confidence interval [CI]: 1.1-2.8, p = 0.02) and in people with susceptibility to burn easily (OR = 3.0, 95%CI: 1.9-4.8; p 〈 0.001). The risk increased with increasing age (p-trend 〈 0.001), increasing time since transplant (p-trend 〈 0.001), increasing self-reported number of sunburns as a child (p(trend) 〈 0.001) and with the presence of viral warts (p 〈 0.001). As expected, antibodies against HPV 16 were associated with a self-reported history of an abnormal cervical smear among women (OR 5.1, 95%CI: 2.6-10.2) and antibodies against HPV 6 were associated with a self-reported history of genital warts (OR 4.0, 95%CI: 2.2-7.2). However, no clear associations between any of the HPV types examined (including cutaneous betaHPVs) and SCC were identified. For example, the seroprevalence of HPV 5 was 15% among cases and 9% among controls (p = 0.09) and the seroprevalence of HPV 8 was 23% among cases and 21% among controls (p = 0.6). Nor was seropositivity to multiple types associated with SCC. These serological data do not provide evidence for a role for HPV in the aetiology of cutaneous SCC among OTR in two UK-based populations. (C) 2009 UICC
    Type of Publication: Journal article published
    PubMed ID: 19588489
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